Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Год журнала: 2024, Номер 1309, С. 138193 - 138193

Опубликована: Март 30, 2024

Язык: Английский

---

4-Chloroskimmetine-based derivatives as potential anticancer and antibacterial prospects: Their synthesis and in vitro inspections

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101511 - 101511

Опубликована: Янв. 1, 2024

Cancer and bacterial infections are among the most high-interest health threats facing humanity. The growing resistance to current-found anticancer antibacterial drugs necessitates exploration of new, effective agents. To synthesize some them, 4-chloroskimmetine (4-CSM), with undefined biological effects, was used as a building block create thirteen its derived coumarins. This precursor Bargellini reaction were produce first coumarin, designated Y0. From which, twelve coumarins coded Y1-Y12 created by esterifying Y0 various halophenols using SOCl2-promoted reaction. FTIR, 1HNMR, 13CNMR spectra analyzed ascertain chemical framework Their potential function prospects evaluated against six cancer-derived populations employing preliminary MTT-facilitated methodology. These MCF-7, HeLa, SKG, AMN3, SK-OV-3, KYSE-30. On other hand, broth microdilution protocol followed specify activity high-infective aerobes. include Pseudomonas aeruginosa, Shigella dysenteriae, Haemophilus influenza, Klebsiella pneumonia, Escherichia coli, Salmonella typhi. results evaluation indicated that presence fluoride on off-side aromatic ring afforded potent activity, Y5 best. For second same findings true, but when halogen is chloride Y2 superior one. authors concluded 4-CSM, can be exploited bioactive activities. Also, considered promising structural templates for producing medications, respectively.

Язык: Английский

---

Synthesis and evaluation of linearly fused thiadiazolocoumarins as prospects with broad-spectrum bioactivity

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101494 - 101494

Опубликована: Янв. 1, 2024

Various pharmacological properties of coumarins brought them under light among the heterocyclics. Also, coumarin derivatives still approve their importance in medical field as a valuable building block to elicit further with diverse, potent, and interesting biological activities. Moreover, numerous actions thiadiazole-based compounds contribute notion this unique synthesis linearly fused thiadiazolocoumarins using molecular hybridization method. This work reported novel seven thiadiazolocoumarins, including Precursor N-III TDA1-TDA6. These were characterized by physicochemical through spectrophotometric tools, FTIR, 1H NMR, 13C NMR. pharmacokinetics predicted computer-based studies SwissADME PreADMET programs. Furthermore, checked for several activities, anticancer, biosafety, anti-oxidative stress, anti-inflammatory, antimicrobial, normal flora safety, antidiabetic According results, TDA3 showed greatest anticancer activity against examined cancer cell lines, highest cellular biosafety. TDA4 higher stress than other derivatives. All prepared significant inflammation-inhibitory toward LOX-5 enzyme while showing poor towards COX enzymes. antimicrobial activity, exhibited anti-gram-negative also best safety flora. TDA1 promising anaerobic bacteria, N-III, TDA3, antifungal activity. Finally, demonstrated moderate which was The authors concluded from gathered results that represent key structures developing versatile bioactivities.

Язык: Английский

---

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(6)

Опубликована: Апрель 15, 2024

For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, 1.6 T), time interval (30, 60, 90 min), temperature (45, 55, 65 °C). Numerous phytochemical categories were detected 81 crude chloroform extracts green sweet bell pepper seeds that collected, according to analysis. Nine discovered be linked coumarin chemical class have same two parameters: 90-minute duration 55 °C temperature. To enable their contents chemically separated chromatographically purified, these containing chosen. Four new phytocoumarins been identified molecular structures distinguished using FTIR spectra,

Язык: Английский

---

Coumarin hybrids: a sighting of their roles in drug targeting

Chemical Papers, Год журнала: 2024, Номер 78(10), С. 5753 - 5772

Опубликована: Май 20, 2024

Язык: Английский

---

Synthesis of novel 6-aminocoumarin derivatives as potential –biocompatible antimicrobial and anticancer agents

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139658 - 139658

Опубликована: Авг. 15, 2024

Язык: Английский

---

Digital alchemy: Exploring the pharmacokinetic and toxicity profiles of selected coumarin-heterocycle hybrids

Results in Chemistry, Год журнала: 2024, Номер 10, С. 101754 - 101754

Опубликована: Авг. 1, 2024

Язык: Английский

---

3-mercaptocoumarins as potential bioactive candidates: From novel synthesis to comparative analysis

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139657 - 139657

Опубликована: Авг. 14, 2024

Язык: Английский

---

Synthesis of novel skipped diene-3-halocoumarin conjugates as potent anticancer and antibacterial biocompatible agents

Results in Chemistry, Год журнала: 2024, Номер 11, С. 101846 - 101846

Опубликована: Окт. 1, 2024

Язык: Английский

---

Advanced Functional Polymers: The Role of Tyrosine-Coumarin Modifications in Optical and Electrical Performance

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Advanced functional polymeric materials can possess chemical reactivity, catalytic properties, photosensitivity, electrical conductivity, biological activity, biocompatibility, pharmacological selective separation, and energy conversion of traditional polymers. Because these the production characterization polymers has become an essential part modern industry advanced technology. Methacrylate are highly versatile owing to their exceptional properties including superior optical transparency, excellent light transmission, robust thermal stability. This study investigates a class methacrylate coincorporating coumarin tyrosine units, aiming explore synergistic effects moieties on polymers' optoelectronic properties. The were synthesized characterized, revealing significant alterations in electronic structure due incorporation coumarin-tyrosine hybrids into backbone. Optical assessed via UV-vis photoluminescence spectroscopy, demonstrating solvent-dependent red shifts intense emission peaks, indicative efficient charge transfer between coumarin. results highlight potential novel for applications optoelectronics offer new insights synthesis, functionalization, performance. In this study, diode observed that exhibited effective behavior with calculated ideality factors (n) 2.68 2.78, barrier heights (Φb) 0.45 0.46 eV, respectively, indicating more height compared previously reported studies. work contributes expanding knowledge tunable semiconducting polymers, paving way future innovations material science.

Язык: Английский

---