Recent advances in the management of lung cancer

Clinical Medicine, Год журнала: 2018, Номер 18(2), С. s41 - s46

Опубликована: Апрель 1, 2018

ABSTRACT

Historically, the prognosis for individuals diagnosed with lung cancer has been bleak. However, past 10 years have seen important advances in treatment and diagnosis which translated into first improvements survival. This review highlights major treatments curative intent, systemic targeted therapies, palliative care early cancer. We discuss pivotal research that underpins these new technologies/strategies their current position clinical practice.

Язык: Английский

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Annual Report to the Nation on the Status of Cancer, Part 1: National Cancer Statistics

JNCI Journal of the National Cancer Institute, Год журнала: 2021, Номер 113(12), С. 1648 - 1669

Опубликована: Июнь 28, 2021

The American Cancer Society, Centers for Disease Control and Prevention, National Institute, North Association of Central Registries collaborate to provide annual updates on cancer incidence mortality trends by type, sex, age group, racial/ethnic group in the United States. In this report, we also examine stage-specific survival melanoma skin (melanoma).Incidence data all cancers from 2001 through 2017 cases diagnosed during 2001-2014 followed-up 2016 were obtained Prevention- Institute-funded population-based registry programs compiled Registries. Data deaths 2018 Center Health Statistics' Vital Statistics System. Trends age-standardized death rates 2-year relative estimated joinpoint analysis, expressed as average percent change (AAPC) most recent 5 years (2013-2017 2014-2018 mortality).Overall (per 100 000 population) ages 2013-2017 487.4 among males 422.4 females. During period, remained stable but slightly increased females (AAPC = 0.2%, 95% confidence interval [CI] 0.1% 0.2%). Overall 185.5 133.5 overall decreased both -2.2%, CI -2.5% -1.9%) -1.7%, -2.1% -1.4%); 11 19 common 14 20 females, each sex. 2014-2018, declines accelerated lung melanoma, slowed down colorectal female breast cancers, leveled off prostate cancer. Among children younger than 15 adolescents young adults aged 15-39 years, continued decrease contrast increasing rates. Two-year distant-stage was those 2001-2009 3.1% (95% 2.8% 3.5%) per year 2009-2014, with comparable females.Cancer States continue decline many types, melanoma. For several other major however, increase or previous have ceased. Moreover, children, adults. These findings inform efforts related prevention, early detection, treatment broad equitable implementation effective interventions, especially under resourced populations.

Язык: Английский

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Survival Rates After Lobectomy, Segmentectomy, and Wedge Resection for Non-Small Cell Lung Cancer

The Annals of Thoracic Surgery, Год журнала: 2018, Номер 105(5), С. 1483 - 1491

Опубликована: Фев. 17, 2018

Язык: Английский

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Stereotactic Body Radiotherapy for Early-Stage Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Guideline

Journal of Clinical Oncology, Год журнала: 2017, Номер 36(7), С. 710 - 719

Опубликована: Ноя. 6, 2017

Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on treatment with stereotactic body radiotherapy (SBRT) patients early-stage non-small-cell lung cancer. ASCO has a policy and set of procedures endorsing and/or adapting clinical practice guidelines that have been developed by other professional organizations. Methods ASTRO Evidence-Based Guideline Stereotactic Body Radiotherapy Early-Stage Non-Small-Cell Lung Cancer was reviewed developmental rigor methodologists. An Expert Panel updated the literature search content recommendations. Results determined recommendations from guideline, published in 2017, are clear, thorough, based most relevant scientific evidence. statements minor modifications were added to enhance applicability broader audience. Recommendations For standard operative risk stage I NSCLC, SBRT is not recommended outside trial. Lobectomy systematic lymph node evaluation remains treatment, although sublobar resection may be considered select scenarios. provided regarding use high inoperative patients, including challenging scenarios where tumors are: centrally located, > 5 cm diameter, lacking tissue diagnosis, synchronous primary or multifocal, second after pneumonectomy, proximal involved mediastinal structures, abutting chest wall, recurring previous treatment. Qualifying included provide further guidance implementation, importance discussion options among members multidisciplinary cancer care team emphasized. Additional information available at: www.asco.org/thoracic-cancer-guidelines www.asco.org/guidelineswiki .

Язык: Английский

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The evolving role of radiotherapy in non-small cell lung cancer

British Journal of Radiology, Год журнала: 2019, Номер 92(1104)

Опубликована: Сен. 5, 2019

Lung cancer is the most commonly diagnosed and biggest cause of mortality worldwide with non-small cell lung (NSCLC) accounting for cases. Radiotherapy (RT) plays a key role in its management used at least once over half patients both curative palliative treatments. This narrative review will demonstrate how evolution RT NSCLC has been underpinned by improvements technology. These have facilitated geometric individualization, increasingly accurate treatment now offer ability to deliver truly individualized RT. In this review, we summarize discuss recent developments field advanced early stage, locally metastatic NSCLC. We highlight limitations current approaches future potential strategies

Язык: Английский

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Video‐assisted thoracoscopic surgery as the gold standard for lung cancer surgery

Respirology, Год журнала: 2020, Номер 25(S2), С. 49 - 60

Опубликована: Июль 30, 2020

Surgical resection remains the only effective means of cure in vast majority patients with early-stage lung cancer. It can be performed via a traditional open approach (particularly thoracotomy) or minimally invasive approach. VATS is 'keyhole' surgery chest, and was first used for cancer early 1990s. Since then, large volume evolving clinical evidence has confirmed that offered proven safety feasibility, better patient-reported post-operative outcomes, less surgical trauma as quantified by objective outcome measures equivalent survival than surgery. This firmly established choice today. Although impressive new non-surgical therapies have emerged recent years, also being constantly rejuvenated development 'next generation' techniques, refinement sublobar selected patients, utilization bespoke recovery programmes synthesis into multi-modality therapy. There little doubt will remain gold standard foreseeable future.

Язык: Английский

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Stereotactic Ablative Radiation Therapy Versus Surgery in Early Lung Cancer: A Meta-analysis of Propensity Score Studies

International Journal of Radiation Oncology*Biology*Physics, Год журнала: 2018, Номер 101(1), С. 186 - 194

Опубликована: Фев. 3, 2018

Язык: Английский

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A systematic review and meta-analysis of stereotactic body radiation therapy versus surgery for patients with non–small cell lung cancer

Journal of Thoracic and Cardiovascular Surgery, Год журнала: 2018, Номер 157(1), С. 362 - 373.e8

Опубликована: Сен. 16, 2018

Stereotactic body radiation therapy is the preferred treatment modality for patients with inoperable early-stage non-small cell lung cancer. However, comparative outcomes between stereotactic and surgery high-risk remain controversial. The primary aim of present meta-analysis was to assess overall survival in matched unmatched patient cohorts undergoing or surgery. Secondary end points included cancer-specific survival, disease-free disease recurrence, perioperative outcomes.

Язык: Английский

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A system‐based intervention to reduce Black‐White disparities in the treatment of early stage lung cancer: A pragmatic trial at five cancer centers

Cancer Medicine, Год журнала: 2019, Номер 8(3), С. 1095 - 1102

Опубликована: Фев. 4, 2019

Abstract Background Advances in early diagnosis and curative treatment have reduced high mortality rates associated with non‐small cell lung cancer. However, racial disparity survival persists partly because Black patients receive less than White patients. Methods We performed a 5‐year pragmatic, trial at five cancer centers using system‐based intervention. Patients diagnosed stage cancer, aged 18‐85 were eligible. Intervention components included: (1) real‐time warning system derived from electronic health records, (2) race‐specific feedback to clinical teams on completion rates, (3) nurse navigator. Consented compared retrospective concurrent controls. The primary outcome was receipt of treatment. Results There 2841 (16% Black) the group 360 (32% intervention group. For baseline, crude 78% for vs 69% ( P < 0.001); difference by race confirmed model adjusted age, site, stage, gender, comorbid illness, income‐odds ratio OR ) 0.66 (95% CI 0.51‐0.85, = 0.001). Within cohort, rate 96.5% 95% 0.56). Odds analysis 2.1 0.41‐10.4, 0.39) Between analyses parity Conclusion A tested gaps improved care all.

Язык: Английский

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Stereotactic Body Radiation Therapy Versus Surgery for Early Lung Cancer Among US Veterans

The Annals of Thoracic Surgery, Год журнала: 2017, Номер 105(2), С. 425 - 431

Опубликована: Ноя. 30, 2017

Язык: Английский

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