Journal of Neural Transmission, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Cochrane library, Год журнала: 2023, Номер 2023(1)
Опубликована: Янв. 31, 2023
Язык: Английский
Процитировано
101
Опубликована: Апрель 10, 2025
Prescribing medications to older people is difficult due comorbidity, limited evidence for efficacy, increased risk of adverse drug reactions, polypharmacy, and altered pharmacokinetics. This article describes the principles underlying clinical geriatric pharmacology including approaches evaluating benefit, adjusting dose age related pharmacokinetic changes. The challenge general practitioner balance an incomplete base efficacy in frail, against problems reactions without denying potentially valuable pharmacotherapeutic interventions.
Язык: Английский
Процитировано
62
British Journal of Sports Medicine, Год журнала: 2022, Номер 56(23), С. 1375 - 1380
Опубликована: Сен. 16, 2022
Objective To assess the comparative effectiveness of exercise, antidepressants and their combination for alleviating depressive symptoms in adults with non-severe depression. Design Systematic review network meta-analysis. Data sources Embase, MEDLINE, PsycINFO, Cochrane Library, Web Science, Scopus SportDiscus. Eligibility criteria Randomised controlled trials (1990–present) that examined an antidepressant or intervention against either treatment alone a control/placebo condition Study selection analysis Risk bias, indirectness overall confidence were assessed by two independent investigators. A frequentist meta-analysis was performed to examine postintervention differences symptom severity between groups. Intervention drop-out as measure acceptability. Results Twenty-one randomised (n=2551) 25 comparisons included network. There no among three main interventions (exercise vs antidepressants: standardised mean differences, SMD, −0.12; 95% CI −0.33 0.10, versus exercise: 0.00; 0.33, −0.40 0.16), although all treatments more beneficial than controls. Exercise had higher rates (risk ratio 1.31; 1.09 1.57). Heterogeneity moderate (τ 2 =0.03; I =46%). Conclusions The results suggest difference exercise pharmacological reducing These findings support adoption alternative adjuvant depression adults. registration PROSPERO CRD4202122656.
Язык: Английский
Процитировано
56
Biological Psychiatry, Год журнала: 2023, Номер 95(11), С. 992 - 1005
Опубликована: Окт. 20, 2023
Язык: Английский
Процитировано
32
Psychological Medicine, Год журнала: 2023, Номер 53(3), С. 654 - 667
Опубликована: Янв. 9, 2023
Abstract Depression in dementia is common, disabling and causes significant distress to patients carers. Despite widespread use of antidepressants for depression dementia, there no evidence therapeutic efficacy, their potentially harmful this patient group. has poor outcomes effective treatments are urgently needed. Understanding why ineffective could provide insight into mechanism action aid identification new targets. In review we discuss may be a distinct entity, current theories how work these mechanisms affected by disease processes dementia. We also consider clinicians continue prescribe novel approaches understand identify living with
Язык: Английский
Процитировано
25
Journal of the American Medical Directors Association, Год журнала: 2024, Номер 25(5), С. 837 - 846.e21
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
13
Discover Mental Health, Год журнала: 2024, Номер 4(1)
Опубликована: Янв. 4, 2024
Abstract Depression is a common and devastating neuropsychiatric symptom in the elderly patients with dementia. In particular, nearly 80% of Alzheimer’s Disease dementia experience depression during disease development progression. However, it unknown whether shares same molecular mechanisms as presenting primary psychiatric or occurs persists through alternative mechanisms. this review, we discuss how clinical presentation treatment differ between disease, focus on major depressive disorder. Then, hypothesize several that may be unique to such neuropathological changes, inflammation, vascular events. Finally, existing issues future directions for investigation
Язык: Английский
Процитировано
8
Journal of Clinical Nursing, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
ABSTRACT Background Depressive symptoms are common among people with dementia (PWD). Exergaming consisting of combined cognitive and physical training in gaming is increasingly used to alleviate their depressive research. With its potential synergistic neurobiological psychosocial effects on reducing PWD, this review aimed understand effectiveness contents. Methods This a systematic the exergames older adults dementia. A search was conducted 7 May 2024 online databases CINAHL, Embase, PsycINFO, PubMed China Academic Journal Network Publishing Database (CNKI). The methodological quality randomised controlled trials (RCT) quasi‐experimental studies assessed RoB2 ROBINS‐I, respectively. meta‐analysis included RCTs conducted. Results Six four two involving 235 participants various stages were included. showed significant overall improvement depression large effect size (SMD = 1.46, 95% CI −2.50, −0.43; p 0.006). Despite high heterogeneity ( I 2 91%), all demonstrated trend after intervention. adopted had following elements: simultaneous motor‐cognitive training, scoring mechanism social play. dose ranged from 15 60 min per session for at least 8 weeks, minimum sessions weekly. However, moderate‐to‐serious risk bias. certainty evidence very low. Conclusion Exergames could be effective improving Yet, moderate‐to‐severe bias shows rigorous study should future. Implications Patient Care provides healthcare professionals informal caregivers use address PWD. Review Registration registered PROSPERO reference CRD42022372762.
Язык: Английский
Процитировано
1
Aging and Disease, Год журнала: 2021, Номер 12(8), С. 1920 - 1920
Опубликована: Янв. 1, 2021
Depression and dementia are the most common neuropsychiatric disorders in older adult population. There a certain number of depressed patients who visit outpatient clinics because they suspect due to similarities clinical symptoms both disorders. Depressive associated with may be diagnosed depression, treatment antidepressants is continued for long time. differ their approaches subsequent courses, it necessary carefully differentiate between two practice treatment. In this review, I describe depression how based on differences emphasize that there significant potential cure contrast dementia, which currently no fundamental therapy. Therefore, important recognize present appropriately suspected having dementia. Dementia disorder cognitive dysfunction caused by variety causative diseases conditions, resulting impairment activities daily living. However, current medical science has had difficulty finding disease. Based findings, also been shown degree preexisting psychiatric alleviated as brain ages. presence speed alleviation will increase. The importance focusing positive aspects aging discussed.
Язык: Английский
Процитировано
47
American Journal of Occupational Therapy, Год журнала: 2024, Номер 78(1)
Опубликована: Янв. 1, 2024
Abstract Importance: There are currently 55 million adults living with declining functional cognition—altered perception, thoughts, mood, or behavior—as the result of Alzheimer’s disease (AD) and related neurocognitive disorders (NCDs). These changes affect performance meaningful engagement in occupations. Given growth demand for services, occupational therapy practitioners benefit from consolidated evidence effective interventions to support AD NCDs their care partners. Objective: Practice Guidelines outline Method: We synthesized clinical recommendations a review recent systematic reviews. Results: Twelve reviews published between 2018 2021 served as foundation practice recommendations. Conclusion Recommendations: Reminiscence, exercise, nonpharmacological behavioral interventions, cognitive therapy, sensory partner education training were found be most NCDs. Plain-Language Summary: provide strong moderate (NCDs) They specific guidance addressing decline cognition, psychological symptoms dementia, pain experience The guidelines also describe With evidence, better equipped address unique needs
Язык: Английский
Процитировано
7