Dietary inflammatory index and all-cause mortality in adults with COPD: a prospective cohort study from the NHANES 1999–2018

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Сен. 25, 2024

Chronic inflammation is closely linked to Obstructive Pulmonary Disease (COPD); however, the impact of Dietaryq Inflammatory Index (DII) on mortality among COPD patients remains uncertain.

Язык: Английский

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Developing and validating machine learning-based prediction models for frailty occurrence in those with chronic obstructive pulmonary disease

Journal of Thoracic Disease, Год журнала: 2024, Номер 16(4), С. 2482 - 2498

Опубликована: Апрель 1, 2024

Background: Frailty is a medical syndrome caused by multiple factors, characterized decreased strength, endurance, and diminished physiological function, resulting in increased susceptibility to dependence and/or death. Patients with chronic obstructive pulmonary disease (COPD) tend be more vulnerable frailty due their physical psychological burdens. Therefore, the aim of this study was develop reliable accurate vulnerability risk prediction model for patients COPD order improve identification patient frailty. The specific objectives were determine prevalence evaluate its predictive power. Methods: Clinical information analyzed using data from 2018 China Health Retirement Longitudinal Study (CHARLS) database, 34 indicators, including behavioral health status, mental parameters, various sociodemographic variables, examined study. adaptive synthetic sampling technique used unbalanced data. Three methods, ridge regressor, extreme gradient boosting (XGBoost) classifier, random forest (RF) filter predictors. Seven machine learning (ML) techniques logistic regression (LR), support vector machines (SVM), multilayer perceptron, light gradient-boosting machine, XGBoost, RF, K-nearest neighbors analyze optimal model. For customized assessment, an online modeling website created, along Shapley additive explanation (SHAP) interpretations. Results: Depression, smoking, gender, social activities, dyslipidemia, asthma, residence type (urban vs. rural) predictors development COPD. In test set, XGBoost had area under curve 0.942 (95% confidence interval: 0.925–0.959), accuracy 0.915, sensitivity 0.873, specificity 0.911, indicating that it best Conclusions: ML developed useful easy-to-use instrument assessing may aid clinical physicians screening high-risk patients.

Язык: Английский

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Epidemiological characteristics of asthma-COPD overlap, its association with all-cause mortality, and the mediating role of depressive symptoms: evidence from NHANES 2005–2018

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Май 28, 2024

Abstract Background Asthma-COPD overlap (ACO) is a distinct and intricate respiratory condition that requires specific attention management. The objective of this cohort study was to examine the epidemiological characteristics ACO, explore association between ACO all-cause mortality, investigate potential mediating role depressive symptoms in association. Methods This retrospective used data from National Health Nutrition Examination Survey (NHANES) 2005–2018 Death Index (NDI) 2019. A total 22,745 participants were included: 705 with 2352 asthma-only, 853 COPD-only, 18,835 without asthma or COPD. non-ACO group ( N = 22,040) referred individuals ACO. Statistical tests employed assess differences some other groups. Cox proportional hazards models applied evaluate relationship estimating hazard ratios (HR) 95% confidence intervals. Mediation analysis conducted effects on mortality. Results prevalence 3.10% our population. Compared participants, exhibited significantly different characteristics, including higher age, lower family income-to-poverty ratio, body mass index, rates comorbidities i.e., hypertension, diabetes, hyperlipidemia, cardiovascular disease, cancer, poorer dietary habits, rate disorders. significant increase mortality (HR 1.908, 95%CI 1.578–1.307, p < 0.001). proportions mediated by for -associated 8.13% (CI: 4.22%-14.00%, Conclusions revealed strong uncovered psychological mechanism underlying relationship. Our indicates possible necessity offering comprehensive care patients, encompassing early detection, lifestyle guidance, mental health support. Nevertheless, due limitations design dataset, results should be interpreted caution.

Язык: Английский

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Association between frailty and postherpetic neuralgia in the older adult with herpes zoster

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 12, 2025

Introduction Chronic pain is closely related to frailty. Methods A total of 300 older adult patients diagnosed with HZ were selected and admitted our hospital in 2024. basic data questionnaire gathered baseline information, the FRAIL scale was employed evaluate their initial frailty status. Patients who non-frail at followed up for 3 months. They categorized into PHN group non-PHN based on occurrence neuropathic during follow-up. Diverse scales frailty, nutritional status, anxiety, depression among participants. The Chi-square or Kruskal-Wallis tests compare two groups. logistic regression model undertaken explore impact Results Among satisfied inclusion criteria, follow-up collected from 215 patients, comprising 85 cases 130 group. prospective analysis showed that incidence 14.9%. Univariate revealed distributions lesion site, area, anxiety COPD, score statistically significant between groups (χ 2 = 6.127, 4.846, 13.316, 12.967, 6.234, H 2.592, P &lt; 0.05). Nevertheless, age, gender, marital education level, hypertension, diabetes not ( &gt; Binary indicated that, after comprehensive adjustment score, exhibited an higher risk compared cohort (22 cases, OR 3.279, 95% CI 1.327–8.105; 0.010). Conclusion Postherpetic neuralgia increases a factor influencing progression adult.

Язык: Английский

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The J-shaped relationship between body roundness index and adult asthma: insights from NHANES 2001–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 20, 2025

Background Many studies have used Body Mass Index (BMI) to define obesity and examine its potential link adult asthma. However, BMI overlooks body fat distribution, which may significantly impact health. Unlike BMI, the Roundness (BRI) can more accurately reflect distribution. Therefore, this study examined BRI’s relationship with asthma prevalence in U.S. adults. Methods This was based on data from National Health Nutrition Examination Survey (NHANES) between 2001 2018 covered 40,052 participants. Participants were categorized into four quartile groups their BRI levels: Quartile 1 (1.05, 3.80); 2 (3.80, 5.06); 3 (5.06, 6.61); 4 (6.61, 23.48). The association assessed via weighted multivariate logistic regression, smoothed curve fitting, threshold effects, subgroup, sensitivity analysis. predictive power compared waist circumference using z -scores. Results Of population, 5,605 participants had (13.99% prevalence). After adjusting for possible confounders, results showed that higher linked greater (OR = 1.41, 95% CI:1.27, 1.56, p &lt; 0.0001). A J-shaped ( -nonlinearity 0) found, rising when surpassed 4.34. outperformed predicting (BRI: OR 1.180; BMI: 1.169; W.C.: 1.166). Subgroup analyses confirmed our results’ robustness. Conclusion Adult increases increasing levels, showing a relationship. Keeping under 4.34 is vital lowering prevalence, especially overweight or obese individuals. In addition, occurrence.

Язык: Английский

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Association between visceral adiposity index, lipid accumulation products, and frailty in older Americans: the 2007–2018 NHANES cross-sectional study

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 26, 2025

The aim of this study was to investigate the relationship between visceral adiposity index (VAI) and lipid accumulation products (LAP) frailty (FI) in older Americans. Based on data from 2007–2018 National Health Nutrition Examination Survey (NHANES), population consisted 3,396 adults aged 60 years with a mean age 69.48 ± 6.76 years. findings weighted multivariate regression analysis demonstrated strong correlation prevalence greater VAI LAP. In fully adjusted model, association remained significant, an OR 1.49 (95% CI: 1.26, 1.77; p &lt; 0.0001.) LAP also 1.88 1.55, 2.29; 0.0001). Further nonlinear analyses by generalized additive modeling (GAM) revealed significant relationships frailty, effects were more pronounced female population. Subgroup showed that positive correlations across populations there no interaction most subgroups. addition, sensitivity validated robustness these results, further confirming conclusion as independent risk factors for frailty. Finally, ROC outperformed predicting suggesting potential early screening Overall, are elderly have important clinical applications.

Язык: Английский

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Association of energy-adjusted dietary inflammatory index and frailty in older adults with nonalcoholic fatty liver disease

Experimental Gerontology, Год журнала: 2023, Номер 182, С. 112296 - 112296

Опубликована: Окт. 1, 2023

Energy-adjusted dietary inflammatory index (E-DII) can represent daily components and chronic response is an important pathogenesis of aging, nonalcoholic fatty liver disease (NAFLD) frailty. Therefore, the purpose this study to explore association E-DII frailty in older adults with NAFLD.This cross-sectional utilized data from National Health Nutrition Examination Survey (2005-2016) investigate between The NAFLD status was determined using US Fatty Liver Index (FLI) value ≥30. relationship examined through multivariate weighted logistic regression analysis smooth curve fitting. Subgroup analyses were conducted, considering various demographic clinical variables.Our final included 1586 individuals, average age 69.42 years, 53.15 % them males. overall prevalence population 39.42 %. Smooth fitting demonstrated a nearly linear H. pylori. Utilizing analysis, we found that odds ratio (OR) for 1.08 (95%CI, 1.03-1.15). further confirmed independently increased risk frailty.Higher levels be associated NAFLD. However, studies are required fully elucidate precise mechanisms underlying

Язык: Английский

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The causal relationship between risk of developing bronchial asthma and frailty: a bidirectional two-sample Mendelian randomization study

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Дек. 15, 2023

Background A potential link between asthma and frailty has been suggested in previous studies. However, the nature of causal relationship these two conditions warrants further investigation. Therefore, this study assessed bidirectional causality risk using two-sample Mendelian randomization (MR). Methods The data were obtained from genome-wide association (GWAS) dataset, with 337,159 samples representing 175,226 frailty. disorders was by selecting single nucleotide polymorphisms (SNPs), significantly associated both inverse variance weighting (IVW) method used as main analytical to estimate possible influence causality. Sensitivity analysis also performed Mr-Egger intercept, funnel plot, “leave-one-out,” Cochran Q test. In addition, mediators investigated factor analysis. Result IVW showed an increased due genetic susceptibility factors number (OR = 2.325, 95%CI:1.958–2.761; p 6.527498e-22), while no horizontal pleiotropy observed for intercept ( 0.609) plot. value 72.858, 0.024, there heterogeneity Q-value. No SNP “leave-one-out” that had a biasing effect on instrumental variables. 1.088, 95%CI:1.058–1.119; 4.815589e-09). described above, several are complex, leading significant reduction physical activity endurance. Conclusion Our findings suggest probable positive developing frailty, potentially mediated reduced At same time, exists asthma. assessment strategies should include vice versa.

Язык: Английский

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Urban-rural and socio-economic differences in inhaled corticosteroid treatment for chronic obstructive pulmonary disease: A nationwide register-based cross-sectional study

Respiratory Medicine, Год журнала: 2024, Номер 229, С. 107678 - 107678

Опубликована: Май 28, 2024

Язык: Английский

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Low-carbohydrate diet score and chronic obstructive pulmonary disease: a machine learning analysis of NHANES data

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Дек. 18, 2024

Background Recent research has identified the Low-Carbohydrate Diet (LCD) score as a novel biomarker, with studies showing that LCDs can reduce carbon dioxide retention, potentially improving lung function. While link between LCD and chronic obstructive pulmonary disease (COPD) been explored, its relevance in US population remains uncertain. This study aims to explore association likelihood of COPD prevalence this population. Methods Data from 16,030 participants National Health Nutrition Examination Survey (NHANES) collected 2007 2023 were analyzed examine relationship COPD. Propensity matching (PSM) was employed baseline bias. Weighted multivariable logistic regression models applied, restricted cubic spline (RCS) used possible nonlinear relationships. Subgroup analyses performed evaluate robustness results. Additionally, we eight machine learning methods—Boost Tree, Decision Logistic Regression, MLP, Naive Bayes, KNN, Random Forest, SVM RBF—to build predictive their performance. Based on best-performing model, further examined variable importance model accuracy. Results Upon controlling for variables, demonstrated strong correlation odds prevalence. In compared lowest quartile, adjusted ratios (ORs) high quartile 0.77 (95% CI: 0.63, 0.95), 0.74 0.59, 0.93), 0.61 0.48, 0.78). RCS analysis linear inverse Furthermore, random forest exhibited robust efficacy, an area under curve (AUC) 71.6%. Conclusion Our American adults indicates adherence may be linked lower These findings underscore important role tool enhancing prevention efforts within general Nonetheless, additional prospective cohort are required assess validate these

Язык: Английский

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