Biomarker-Concordant Steroid Administration in Severe Coronavirus Disease-2019 DOI
Aysun Tekin, Juan Pablo Domecq, Diana J. Valencia Morales

и другие.

Journal of Intensive Care Medicine, Год журнала: 2023, Номер 38(11), С. 1003 - 1014

Опубликована: Май 24, 2023

Although corticosteroids have become the standard of care for patients with coronavirus disease-2019 (COVID-19) on supplemental oxygen, there is growing evidence differential treatment response. This study aimed to evaluate if was an association between biomarker-concordant corticosteroid and COVID-19 outcomes.This registry-based cohort included adult hospitalized January 2020 December 2021 from 109 institutions. Patients available C-reactive protein (CRP) levels within 48 h admission were evaluated. Those steroids before admission, stayed in hospital <48 h, or not oxygen support excluded. Corticosteroid given high baseline CRP ≥150 mg/L withheld low (<150 mg/L) vice-versa considered discordant (low steroids, without steroids). Hospital mortality primary outcome. Sensitivity analyses conducted using varying level thresholds. The model interaction tested determine steroid effectiveness increasing levels.Corticosteroid 1778 (49%) 1835 (51%). concordant group consisted higher-risk than group. After adjusting covariates, odds in-hospital significantly lower (odds ratio [95% confidence interval (C.I.)] = 0.71 [0.51, 0.98]). Similarly, adjusted difference significant at thresholds 100 200 C.I.] 0.70 [0.52, 0.95] 0.57 [0.38, 0.85], respectively), use associated need invasive ventilation threshold 0.52 [0.30, 0.91]). In contrast, no outcome benefit observed 50. When tested, more effective reducing as increased.Biomarker-concordant severe COVID-19.

Язык: Английский

Interleukin 6 as an energy allocator in muscle tissue DOI Open Access
Timothy M. Kistner, Bente Klarlund Pedersen, Daniel E. Lieberman

и другие.

Nature Metabolism, Год журнала: 2022, Номер 4(2), С. 170 - 179

Опубликована: Фев. 24, 2022

Язык: Английский

Процитировано

187
Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far? DOI Creative Commons
Ivana Lazarević,

Vera Pravica,

Danijela Miljanovic

и другие.

Viruses, Год журнала: 2021, Номер 13(7), С. 1192 - 1192

Опубликована: Июнь 22, 2021

Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive and rapid transmission during COVID-19 pandemic has enabled it acquire significant genetic diversity since first entered human population. This led emergence numerous variants, some them recently being labeled “variants concern” (VOC), due their potential impact on transmission, morbidity/mortality, evasion neutralization by antibodies elicited infection, vaccination, or therapeutic application. The evade is result target epitopes generated accumulation mutations in spike protein. While three globally recognized VOCs (Alpha B.1.1.7, Beta B.1.351, Gamma P.1) remain sensitive albeit at reduced levels sera convalescent individuals recipients several anti-COVID19 vaccines, effect variability much more evident capacity monoclonal antibodies. newly VOC Delta lineage B.1.617.2, as well locally accepted (Epsilon B.1.427/29-US B1.1.7 with E484K-UK) are indicating necessity close monitoring new variants a global level. characteristics, mutational patterns, role play immune summarized this review.

Язык: Английский

Процитировано

183
COVID-19 and the role of cytokines in this disease DOI Open Access
Amin Hasanvand

Inflammopharmacology, Год журнала: 2022, Номер 30(3), С. 789 - 798

Опубликована: Май 4, 2022

Язык: Английский

Процитировано

99
Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications DOI Open Access
Jamal Majidpoor, Keywan Mortezaee

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 145, С. 112419 - 112419

Опубликована: Ноя. 12, 2021

Interleukin-6 (IL-6) is a multi-tasking cytokine that represents high activity in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cancer. High concentration of this pleiotropic accounts for hyperinflammation storm, related to multi-organ failure SARS-CoV-2 induced disease. IL-6 promotes lymphopenia increases C-reactive protein (CRP) such cases. However, blockade not full-proof complete response. Hypoxia, hypoxemia, aberrant angiogenesis chronic inflammation are inter-related events occurring as response the stimulatory effect on activity. Taking both pro- anti-inflammatory activities will make complex targeting patient The aim review was discuss about interactions within body disease who representing levels, determine whether inhibition therapy effective or not. We also address targeted therapies cancer have

Язык: Английский

Процитировано

57
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19) DOI
Reza Elahi,

Parsa Karami,

Amir Hossein Heidary

и другие.

International Immunopharmacology, Год журнала: 2022, Номер 105, С. 108536 - 108536

Опубликована: Янв. 11, 2022

Язык: Английский

Процитировано

45
Interleukin-6 serves as a critical factor in various cancer progression and therapy DOI
Asma’a H. Mohamed, Abdulrahman T. Ahmed, Waleed Al Abdulmonem

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(7)

Опубликована: Июнь 20, 2024

Язык: Английский

Процитировано

15
Neutrophil/Lymphocyte Ratio (NLR) and Lymphocyte/Monocyte Ratio (LMR) – Risk of Death Inflammatory Biomarkers in Patients with COVID-19 DOI Creative Commons
Violetta Dymicka-Piekarska, Justyna Dorf, Anna Justyna Milewska

и другие.

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 2209 - 2222

Опубликована: Май 1, 2023

Aim:The aim of our retrospective study was search for new prognostic parameters, which can help quickly and cheaply identify patients with risk severe course SARS-CoV-2 infection. Materials Methods:The following peripheral blood combination biomarkers were calculated: NLR (neutrophil/lymphocytes ratio), LMR (lymphocyte/monocyte PLR (platelet/lymphocyte dNLR (neutrophils/(white cells -neutrophils)), NLPR (neutrophil/(lymphocyte × platelet ratio)) in 374 who admitted to the Temporary Hospital no 2 Clinical Bialystok (Poland) COVID-19.The divided into four groups depending on severity COVID-19 using MEWS classification. Results:The significantly increased COVID-19, according score.The AUC assessed parameters higher predicting death COVID-19: (0.656, p=0.0018, cut-off=6.22),dNLR (0.615, p=0.02, cut-off=3.52)and (0.609, p=0.03, cut-off=2.06).Multivariate COX regression analysis showed that median above 5.56 (OR: 1.050, P=0.002), below 2.23 1.021, P=0.011), age >75 years old 1.072, P=0.000) had a significant association high during COVID-19. Conclusion:Our results indicate NLR, dNLR, calculated admission hospital easy more COVID-19.Increase decrease have predictive value patient's mortality might be potential biomarker patients.

Язык: Английский

Процитировано

23
Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality DOI Creative Commons

Marie‐Christine Albert,

Iratxe Uranga-Murillo,

Maykel Arias

и другие.

Cell Death and Differentiation, Год журнала: 2024, Номер 31(5), С. 544 - 557

Опубликована: Март 21, 2024

Abstract The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized this process might also or contribute to inflammatory disease lung failure following SARS-CoV-2 infection. To test hypothesis, developed a novel mouse-adapted model (MA20) recapitulates key pathological features of COVID-19. Concomitantly with occurrence FasL expression was significantly increased on monocytic macrophages NK cells the lungs MA20-infected mice. Importantly, therapeutic inhibition markedly survival both, young old mice coincident substantially reduced their lungs. Intriguingly, bronchoalveolar lavage fluid critically-ill patients. Together, these results identify as crucial host factor driving immuno-pathology underlies severity lethality, imply patients may benefit from FasL.

Язык: Английский

Процитировано

7
COVID-19: imbalanced cell-mediated immune response drives to immunopathology DOI Creative Commons
Jun Wang, Qian Li, Yuanwang Qiu

и другие.

Emerging Microbes & Infections, Год журнала: 2022, Номер 11(1), С. 2393 - 2404

Опубликована: Сен. 7, 2022

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), poses an imminent threat to humanity. SARS-CoV-2 invades host cells, causing a failure of immune recognition. Instead effective antiviral immunological response after invasion, the cascading pathological COVID-19, especially in disease, is exacerbated overt inflammatory and suppression SARS-CoV-2–specific responses. As known, excessive inflammation leads pathophysiological changes virus-infected tissues or organs, manifested imbalanced responses, cytokine storm, aggressive neutrophil activation, ultimately leading lung damage, such as alveolar endotheliitis, fluid overload. However, triggers consequences disruption system homeostasis underlying mechanisms uncontrolled immunopathology following viral infection remain unclear. Here, we review dynamic systemic progression from imbalance cell-mediated responses COVID-19 injury. Our understanding key involved pathogenesis critical for development therapeutic agents optimize strategies.

Язык: Английский

Процитировано

24
Myeloid-Derived Suppressor Cells in COVID-19: The Paradox of Good DOI Creative Commons
Germana Grassi,

Stefania Notari,

Simona Gili

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Апрель 27, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of ongoing disease 2019 (COVID-19) pandemic. Viral replication in tract induces death infected cells and release pathogen- associated molecular patterns (PAMPs). PAMPs give rise to local inflammation, increasing secretion pro- inflammatory cytokines chemokines, which attract immune from blood into lung. In most individuals, lung-recruited clear infection, response retreats. However, some cases, a dysfunctional occurs, triggers cytokine storm lung, leading distress (ARDS). COVID-19 characterized by an impaired innate adaptive massive expansion myeloid-derived suppressor (MDSCs). MDSCs function as protective regulators response, protecting host over-immunoreactivity hyper-inflammation. under certain conditions, such chronic inflammation cancer, could exert detrimental role. Accordingly, early able predict fatal outcome infection. Here, we review recent data on during COVID-19, discussing how they can influence course whether be considered biomarker possible targets for new therapeutic approaches.

Язык: Английский

Процитировано

23