Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Дек. 19, 2023

Introduction Mycoplasma pneumoniae pneumonia (MPP) may lead to various significant outcomes, such as necrotizing pneumonia(NP) and refractory MPP (RMPP). We investigated the potential of peripheral blood neutrophil-to-lymphocyte ratio (NLR) predict outcomes in patients with MPP. Methods materials This was a prospective study who were admitted our hospital from 2019 2021. Demographic clinical data collected patient records associated development NP RMPP other outcome measures. Results Of 1,401 included study, 30 (2.1%) developed NP. The NLR an independent predictor (odds 1.153, 95% confidence interval 1.022–1.300, P =0.021). probability greater high (≥1.9) than those low (<1.9) ( <0.001). also 1.246, 1.102–1.408, <0.005). Patients more likely develop require intensive care, had longer total fever duration, stays, higher hospitalization expenses (all Discussion can serve poor prognosis It occurrence NP, RMPP, outcomes. use this indicator would allow simple rapid prediction early stages MPP, enabling implementation appropriate treatment strategies.

Язык: Английский

---

Factors Associated with Mortality Among Severe Omicron Patients for COVID-19

Infection and Drug Resistance, Год журнала: 2024, Номер Volume 17, С. 1309 - 1319

Опубликована: Апрель 1, 2024

The purpose of the study was to explore potential risk factors mortality in patients with severe pneumonia during omicron pandemic South China 2022.

Язык: Английский

---

Assessing the Diagnostic Values of the Neutrophil-to-Lymphocyte Ratio (NLR) and Systematic Immunoinflammatory Index (SII) as Biomarkers in Predicting COVID-19 Severity: A Multicentre Comparative Study

Medicina, Год журнала: 2024, Номер 60(4), С. 602 - 602

Опубликована: Апрель 5, 2024

COVID-19 has been notoriously unpredictable in its clinical course. Such unpredictability poses a challenge to clinicians predicting patients who will develop severe cases and possibly die from the infection. This study aims assess compare diagnostic value of NLR SII as biomarkers severity, represented by mortality, with multicentre comparative including 855 Saudi Arabia. Descriptive analytical statistics were used haematological indices between survivors non-survivors. The median age included was 41 years old, an almost equal ratio men women. Most participants Saudis, mortality rate cohort 13.22%. Non-survivors, compared survivors, significantly older, had lower RBC counts, haemoglobin haematocrit levels, well higher WBC neutrophil counts. Both capable differentiating non-survivors, latter having values. However, superior such differentiation, it larger area under curve. further confirms values severity being more sensitive specific. Clinical guidelines on managing should benefit these findings harnessing management.

Язык: Английский

---

Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 4, 2024

Aim The aim of the present study was to assess differences in serum levels chemokines and growth factors (GFs) between COVID-19 patients healthy controls. diagnostic utility analyzed proteins for monitoring severity SARS-CoV- 2 infection based on patients’ MEWS scores also assessed. Materials methods were hospitalized (50 women, 50 men) with use Bio-Plex Pro™ Human Cytokine Screening Panel (Biorad) Multiplex system. Results demonstrated that MIP-1α, RANTES, Eotaxin, CTACK, GRO-α, IP-10, MIG, basic-FGF, HGF, SCGF-β, G-CSF, M-CSF, SCF, MIF, LIF, TRAIL significant higher than control group. concentrations PDGF- BB, GM-CSF, asymptomatic/mildly symptomatic (stage 1) pneumonia without respiratory failure 2). receiver operating characteristic (ROC) analysis revealed basic-FGF differentiated from controls highest sensitivity specificity, whereas MIG 2) specificity. Conclusions GM-CSF can be useful biomarkers disease COVID-19.

Язык: Английский

---

Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 22, 2024

Abstract Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, aim of this study was to assess selected nitrosative parameters glycoxidation products in COVID-19 patients convalescents relative healthy subjects, including reference severity symptoms. The diagnostic utility biomarkers also evaluated patients. involved 218 COVID-19, 69 convalescents, 48 subjects. (NO, S-nitrosothiols, nitrotyrosine) (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured blood plasma or serum use colorimetric/fluorometric methods. levels NO ( p = 0.0480), S-nitrosothiols 0.0004), nitrotyrosine 0.0175), kynurenine < 0.0001), N-formylkynurenine dityrosine AGEs 0.0001) significantly higher, whereas tryptophan fluorescence lower than control group. Significant differences analyzed observed different stages COVID-19. In turn, concentrations controls. ROC analysis revealed that be useful for diagnosing infections virus because they differentiate (KN: sensitivity—91.20%, specificity—92.00%; NFK: sensitivity—92.37%, AGEs: sensitivity—99,02%, specificity—100%) sensitivity—82.22%, specificity—84.00%; sensitivity—82,86%, specificity—86,00%; DT: sensitivity—100%, specificity—100%; AGE: from subjects high sensitivity specificity. are intensified after redox fluctuate disease. Circulating stress/protein have potential convalescents.

Язык: Английский

---

Redox Biomarkers – An Effective Tool for Diagnosing COVID-19 Patients and Convalescents

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 2589 - 2607

Опубликована: Апрель 1, 2024

Aim: COVID-19 triggers the overproduction of reactive oxygen species (ROS) which, in combination with a weakened antioxidant barrier, can lead to protein oxidation and lipid peroxidation. The aim this study was evaluate enzymatic non-enzymatic antioxidants, overall redox potential, peroxidation products patients, convalescents, healthy subjects, determine diagnostic applicability these parameters patients. Materials Methods: involved 218 patients COVID-19, 69 48 subjects who were selected for research based on age sex. conducted between 20 February 2021 November Białystok, Poland. status, oxidative damage assessed serum/plasma samples use colorimetric spectrophotometric assays. Results: Glutathione reductase (GR) activity higher, whereas total capacity (TAC) lower than convalescents (p< 0.0001) control group 0.0001). concentrations advanced glycation end (AGEs), (AOPP), 4-hydroxynonenal (4-HNE), malondialdehyde (MDA) higher group. AGEs most effective biomarker differentiating from (AUC=0.9971) (AUC=1.000). Conclusion: An infection SARS-CoV-2 disrupts balance increases fulfill criteria potential convalescents. Keywords: stress, biomarkers, SARS CoV-2 virus

Язык: Английский

---

The effect of SARS-CoV-2 Omicron BA. 5.2 infection on perioperative physiological indicators in orthopedic patients

BMC Musculoskeletal Disorders, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 20, 2025

The aim of this study was to investigate the effect SARS-CoV-2 Omicron BA. 5.2 (hereafter referred as 5.2) infection on perioperative physiological indices and provide clinical considerations for precautions needed patients who tested negative perioperatively. Patients underwent time-limited surgery (surgery that must be performed within a certain time) at Department Orthopedics our hospital from September 1, 2022, March 31, 2023, were divided into an observation group (those with BA nucleic acid test after December 7, n = 100) control before 100). Changes in following factors compared between two groups: heart rate, mean arterial pressure, oxygenation index time entry operating room, incision skin exit room neutrophil‒lymphocyte ratio (NLR), platelet‒lymphocyte (PLR), systemic immune inflammation (SII), D-dimer level, fibrinogen degradation product (FDP) level. interleukin-6 calcitonin levels assessed day surgery, multivariate regression analysis meaningful results conducted. Heart index, NLR, PLR, SII, similar groups (P > 0.05). had higher postoperative FDP < Multivariate revealed infection, older age history cerebral infarction associated increased levels, their odds ratios (ORs) confidence intervals are 3.339 [95% CI, 1.372–8.419], P 0.008; OR, 1.080 1.023–1.139]; 0.005; 10.644 1.352–83.320], 0.025, respectively. Infection affects coagulation function orthopedic patients, thereby inducing hypercoagulable state characterized by significant elevations increasing risk venous thrombosis. This no obvious other indices. Early is feasible, but thrombotic events need considered.

Язык: Английский

---

Potential Utility of Systemic Immune-Inflammation Index: NLR, PLR, and SII to Detect Poor Prognosis of COVID-19 Patients from the Mexican Southeast

Archives of Clinical Infectious Diseases, Год журнала: 2025, Номер 20(3)

Опубликована: Фев. 8, 2025

Background: Since December 2019, the SARS-CoV-2 virus has been highly contagious and pathogenic, causing mild to severe respiratory failure. The most investigated biomarkers can help predict disease progression guide treatment decisions. Expert clinicians suggested that neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) represent rapid, easy, widely available, relatively inexpensive tools. Objectives: We aimed explore NLR PLR in predicting poor prognosis of COVID-19 patients Mexican Southeast. Methods: In this retrospective study, we included hospitalized adults with from Dr. Juan Graham Casasús Hospital who had survived or non-survived between June 2020 January 2022. Demographic laboratory data were acquired electronic medical records. calculated NLR, PLR, SII. continuous variables expressed as average compared Student t-test, well categorical variables. These numbers percentages χ2 test survivor group non-survivor group. sensitivity specificity prediction death according cutoff values SII by ROC curve. P less than 0.05 considered significant. Results: admitted 189 patients. age was 61.8 ± 17.3 years, 59.8% (n = 113) men, 55.6% 105) non - survivors. showed differences among survivors survivors, (65.6 vs. 56.9 0.001), white blood cell count (14.1 10.2 neutrophil (12.4 8.5 0.002), CRP (213.7 158.5 0.003), IL 6 (192.3 81.0 0.005), (23.5 11.4 0.000), (524.8 287.6 0.010), (6982.0 3003.1 0.004). optimal for 8.6 a 70.4% 51.8 (AUC 0.678, CI 95% 0.6024 0.7541, < 0.0001), where it shows 252.6 60.0% 50.6 0.6096, 0.5297 0.6895, 0.0099), 1815 70.4%, 0.6566, 0.5788 0.7344, 0.0002). Conclusions: propose should be an inexpensive, accessible, effective biomarker management COVID-19. conclusion, high related

Язык: Английский

---

Lymphocyte to monocyte ratio and lymphocyte to neutrophil ratio in neurosyphilis may affect the response to therapy and diagnostic efficacy

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 8, 2025

To investigate the effects of lymphocyte to monocyte ratio (LMR), neutrophil (LNR), and serum toluidine red unheated test (sero-TRUST) titers on therapy response HIV negative neurosyphilis (NS) patients after initial therapy. NS who received at Second Hospital Nanjing were selected as research participants, demographic data, well clinical laboratory collected through follow-up.Group study population based status, with complete endpoint study. Cox regression analysis factors influencing Time-dependent ROC curve evaluation LMR LNR prediction ability. Among 249 included in this study, 200 group 49 non-response group. found that baseline blood > 1.93, 0.3, sero-TRUST titer 1:16 can affect outcomes. However, there was no statistically significant difference between without The time-dependent shows AUC for evaluating is moderately sensitive titers, or 3 months therapy, from baseline. Baseline 1.93 ≥ may be important prognostic affecting patients. 1:16, increase 0.12 decrease 2-fold used auxiliary indicators evaluate occurrence

Язык: Английский

---

Prognostic Value of Biomarkers in COVID-19: Associations with Disease Severity, Viral Variants, and Comorbidities—A Retrospective Observational Single-Center Cohort Study

Life, Год журнала: 2025, Номер 15(4), С. 634 - 634

Опубликована: Апрель 10, 2025

Coronavirus disease (COVID-19) exhibits a wide spectrum of clinical severity and has been associated with specific biomarkers linked to progression outcomes. This retrospective study analyzed sera from 1222 adult COVID-19 patients hospitalized at the University Hospital for Infectious Diseases in Croatia. We examined association between several laboratory biomarker levels measured patient admission severity, fatal outcomes, viral variants parameters. Deceased surviving severe exhibited significantly elevated on admission, including hs-troponin T, N-terminal pro-brain natriuretic peptide, creatine kinase, C-reactive protein, procalcitonin, interleukin-6, lactate dehydrogenase, lactate, urea creatinine. Random forest models identified lymphocyte percentage, D-dimers, T as most important outcome prediction, achieving 84.1% accuracy. Patients infected Delta SARS-CoV-2 variant higher proinflammatory, cardiac renal biomarkers. Vaccination correlated reduced proinflammatory parameters proportions. Hypertension, chronic diabetes were increased cardiac, metabolic levels, respectively. These findings highlight variants, vaccination status comorbidities, potentially offering prognostic insights into

Язык: Английский

---