Cell Reports, Год журнала: 2025, Номер 44(2), С. 115234 - 115234
Опубликована: Янв. 23, 2025
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)
Опубликована: Апрель 2, 2024
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.
Язык: Английский
Процитировано
161
Biomedicines, Год журнала: 2024, Номер 12(1), С. 187 - 187
Опубликована: Янв. 15, 2024
In recent years, the field of drug delivery has witnessed remarkable progress, driven by quest for more effective and precise therapeutic interventions. Among myriad strategies employed, integration aptamers as targeting moieties stimuli-responsive systems emerged a promising avenue, particularly in context anticancer therapy. This review explores cutting-edge advancements targeted drug-delivery systems, focusing on platforms enhanced spatial aptamer-based we delve into versatile applications aptamers, examining their conjugation with gold, silica, carbon materials. The synergistic interplay between these materials is discussed, emphasizing potential achieving delivery. Additionally, explore an emphasis Tumor microenvironment-responsive nanoparticles are elucidated, capacity to exploit dynamic conditions within cancerous tissues controlled release detailed. External strategies, including ultrasound-mediated, photo-responsive, magnetic-guided examined role effects. integrates diverse approaches precision medicine, showcasing revolutionize
Язык: Английский
Процитировано
20
Molecular Oncology, Год журнала: 2024, Номер 18(7), С. 1719 - 1738
Опубликована: Янв. 12, 2024
Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an established antidiabetic drug, mildly inhibits mitochondrial complex I, while is a new potent I inhibitor. Mitochondria pivotal in the energy metabolism of cells by providing adenosine triphosphate through oxidative phosphorylation (OXPHOS). Hence, OXPHOS become vulnerability when targeted cancer cells. Both drugs have promising antitumoral effects diverse cancers, supported preclinical vitro vivo studies. We present evidence their direct impact on immunomodulatory effects. In clinical studies, observational epidemiologic studies metformin were encouraging, actual trial results not as expected. However, IACS‐01075 exhibited major adverse effects, thereby causing metabolic shift to glycolysis elevated lactic acid concentrations. Therefore, future outlook for these depends preventive trials investigations into plausible toxic normal IACS‐01075.
Язык: Английский
Процитировано
17
MedComm, Год журнала: 2024, Номер 5(6)
Опубликована: Май 23, 2024
Abstract Cancer is one of the leading causes death worldwide, and more effective ways attacking cancer are being sought. immunotherapy a new therapeutic method after surgery, radiotherapy, chemotherapy, targeted therapy. aims to kill tumor cells by stimulating or rebuilding body's immune system, with specific efficiency high safety. However, only few patients respond due complex variable characters escape, behavior regulatory mechanisms need be deeply explored from dimensions. Epigenetic modifications, metabolic modulation, cell‐to‐cell communication key factors in cell adaptation response microenvironment. They collectively determine state function through modulating gene expression, changing energy nutrient demands. In addition, engage networks other components, which mediated exosomes, cytokines, chemokines, pivotal shaping progression response. Understanding interactions combined effects such multidimensions modulation important for revealing failure developing targets strategies.
Язык: Английский
Процитировано
13
Advanced Functional Materials, Год журнала: 2024, Номер 34(25)
Опубликована: Янв. 28, 2024
Abstract The complex tumor immune pathology requires a precise spatial‐control release of the combination drugs, but most multi‐drug loaded nanoparticles all drugs simultaneously in microenvironment (TME), making them difficult to reach exact action site. To address spatial specific carrier‐free self‐assembled multi‐responsive nanodrug delivery system is designed, which p ‐phthalaldehyde ( ‐APA) and dithiodipropionic acid are used connect metformin (MET) 7‐ethyl‐10‐hydroxycamptothecin (SN38) through matrix metalloproteinase‐2 (MMP‐2) responsive peptide, dipyridamole (DIP) further (MA‐GPLGVRGDK‐SS‐SN38@DIP, MR NPs). NPs first target by enhanced permeability retention effect, then highly expressed MMP‐2 at site cleaves GPLGVRGDK, breaking nanoparticle into three parts—DIP, MA‐GPLG, VRGDK‐SS‐SN38. DIP automatically binds with platelets TME, inhibiting their function restraining metastasis. MA‐GPLG releases MET response acidic TME reverse immunosuppressive networks PD‐L1 downregulation M2‐like macrophages repolarization. Moreover, VRGDK‐SS‐SN38 overexpressed integrin α v β 3 receptor achieve cells killing. Overall, this study offers an intelligent spatial‐specific drug breast cancer, specifically, therefore reverses inhibits
Язык: Английский
Процитировано
11
Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)
Опубликована: Фев. 17, 2024
Abstract Translational research plays a key role in drug development and biomarker discovery for hepatocellular carcinoma (HCC). However, unique challenges exist this field because of the limited availability human tumor samples from surgery, lack homogenous oncogenic driver mutations, paucity adequate experimental models. In review, we provide insights into these review recent advancements, with particular focus on two main agents currently used as mainstream therapies HCC: anti-angiogenic immunotherapy. First, examine pre-clinical clinical studies to highlight determining optimal therapeutic combinations biologically effective dosage HCC. Second, discuss focusing anti-PD1/anti-PD-L1-based combination therapy. Finally, progress made our collective understanding immunology multi-omics analysis technology, which enhance mechanisms underlying immunotherapy, characterize different patient subgroups, facilitate novel approaches improve treatment efficacy. summary, provides comprehensive overview efforts translational aiming at advancing improving
Язык: Английский
Процитировано
11
Endocrine Reviews, Год журнала: 2024, Номер 45(4), С. 521 - 552
Опубликована: Фев. 20, 2024
Abstract Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells adrenal medullary chromaffin tissues extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal options advanced metastatic cases have been limited. Hence, understanding role of immune system in PPGL tumorigenesis can provide essential knowledge development better therapeutic tumor management strategies, especially those with PPGLs. The first part this review outlines fundamental principles microenvironment, their cancer immunoediting, particularly emphasizing We focus on how unique pathophysiology PPGLs, such as high molecular, biochemical, imaging heterogeneity production several oncometabolites, creates a tumor-specific microenvironment immunologically “cold” tumors. Thereafter, we discuss recently published studies related to reclustering based signature. second discusses future perspectives management, including immunodiagnostic promising immunotherapeutic approaches converting into active or “hot” known immunotherapy response patient outcomes. Special emphasis placed potent immune-related strategies signatures that could be used reclassification, prognostication, these improve care prognosis. Furthermore, introduce currently available immunotherapies possible combinations other therapies an emerging targets hostile environments.
Язык: Английский
Процитировано
11
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(4)
Опубликована: Июнь 1, 2024
Metformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent studies show that apart from its blood glucose-lowering effects, it also inhibits development various tumours, by inducing autophagy. Various have confirmed inhibitory effects MET on cancer cell lines' propagation, migration, and invasion. The objective study was to comprehensively review potential as an anticancer agent, particularly focusing ability induce autophagy inhibit progression tumors. aimed explore proliferation, invasion, impact key signaling pathways such adenosine monophosphate-activated protein kinase (AMPK), mammalian target rapamycin (mTOR), PI3K. This noted exerts regulating signalling phosphoinositide 3-kinase (PI3K), LC3-I LC3-II, Beclin-1, p53, autophagy-related gene (ATG), inhibiting mTOR protein, downregulating expression p62/SQSTM1, blockage cycle at G0/G1. Moreover, can stimulate through associated with 5' AMPK, thereby he human cancers, including hepatocellular carcinoma, prostate cancer, pancreatic osteosarcoma, myeloma, non-small lung cancer. In summary, this detailed provides framework further investigations may appraise autophagy-induced repurposing treatment.
Язык: Английский
Процитировано
10
Advanced Science, Год журнала: 2024, Номер 11(18)
Опубликована: Март 23, 2024
Complete remission of colorectal cancer (CRC) is still unachievable in the majority patients by common fractionated radiotherapy, leaving risks tumor metastasis and recurrence. Herein, clinical CRC samples demonstrated a difference phosphorylation translation initiation factor eIF2α (p-eIF2α) activating transcription 4 (ATF4), whose increased expression initial X-ray irradiation led to resistance subsequent radiotherapy. The underlying mechanism studied radio-resistant CT26 cells, revealing that incomplete mitochondrial outer membrane permeabilization (iMOMP) triggered key for elevated p-eIF2α ATF4, therefore radio-resistance. This finding guided discover metformin 2-DG are synergistic reversing radio inhibiting ATF4. Liposomes loaded with (M/D-Lipo) thus prepared enhancing radiotherapy CRC, which achieved satisfactory therapeutic efficacy both local metastatic tumors radio-resistance preventing T lymphocyte exhaustion.
Язык: Английский
Процитировано
8
APL Bioengineering, Год журнала: 2024, Номер 8(2)
Опубликована: Апрель 2, 2024
The tumor microenvironment (TME), composed of and influenced by a heterogeneous set cancer cells an extracellular matrix, plays crucial role in progression. biophysical aspects the TME (namely, its architecture mechanics) regulate interactions spatial distributions immune cells. In this review, we discuss factors TME—notably, as well stromal cells—that contribute to pro-tumor, immunosuppressive response. We then ways which innate adaptive systems respond tumors from both biochemical perspectives, with increased focus on CD8+ CD4+ T Building upon information, turn immune-based antitumor interventions—specifically, recent breakthroughs aimed at improving CAR-T cell therapy.
Язык: Английский
Процитировано
8