For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy
Soroush Karimi,
Roksana Bakhshali,
Soheil Bolandi
и другие.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer
treatment
is
challenged
by
the
tumor
microenvironment
(TME),
which
promotes
drug
resistance
and
cancer
cell
growth.
This
review
offers
a
comprehensive
innovative
perspective
on
how
nanomedicine
can
modify
TME
to
enhance
therapy.
Strategies
include
using
nanoparticles
improve
oxygenation,
adjust
acidity,
alter
extracellular
matrix,
making
treatments
more
effective.
Additionally,
immune
responses
activating
cells
reducing
suppression
within
tumors.
By
integrating
these
approaches
with
existing
therapies,
such
as
chemotherapy
radiotherapy,
show
promise
in
overcoming
traditional
barriers.
The
discusses
changes
effectiveness
of
itself,
creating
reciprocal
relationship
that
boosts
overall
efficacy.
We
also
highlight
novel
strategies
aimed
at
exploiting
TME,
leveraging
nanoparticle-based
for
targeted
therapy
through
precise
modulation.
Язык: Английский
Cascade Carrier‐Free Nanoparticles Forming In Situ Nanovaccines for Synergistic Photothermal‐Immunotherapy of Cancer
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Апрель 5, 2024
Abstract
Rapid
advances
in
nanotechnology
have
made
it
possible
to
combine
photothermal
therapy
(PTT)
with
immunotherapy,
enabling
activate
an
situ
vaccine
effect.
However,
this
effect
is
severely
impeded
by
low
antigen
presentation
level
and
highly
suppressive
tumor
immune
microenvironment
(immune
“cold”
tumors).
To
overcome
the
obstacles,
multifunctional
carrier‐free
nanoparticles
(FCDP‐NPs)
assembled
from
Fe
2+
,
toll‐like
receptor
9
agonist
(CpG),
cationic
lipid
(DOTAP)
agent
polydopamine
are
developed.
After
intratumoral
injection,
FCDP‐NPs
carrying
positive
charge
exposed
under
laser
irradiation,
which
can
capture
tumor‐associated
antigens
(TAAs)
generated
upon
post‐PTT
form
nanovaccines
(FCD‐NPs@TAAs).
The
further
promote
cross‐presentation
of
TAAs,
stimulate
adaptive
responses,
shape
“hot”
tumors.
As
a
result,
improve
survival
rates
elicit
durable
memory
that
remarkedly
prevents
metastasis,
illustrating
useful
platform
for
PTT
synergized
immunotherapy.
Язык: Английский
A computer-aided, heterodimer-based “triadic” carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
677, С. 523 - 540
Опубликована: Авг. 14, 2024
Язык: Английский
Carrier-Free Nanodrugs: From Bench to Bedside
ACS Nano,
Год журнала:
2024,
Номер
18(35), С. 23827 - 23841
Опубликована: Авг. 20, 2024
Carrier-free
nanodrugs
with
extraordinary
active
pharmaceutical
ingredient
(API)
loading
(even
100%),
avoidable
carrier-induced
toxicity,
and
simple
synthetic
procedures
are
considered
as
one
of
the
most
promising
candidates
for
disease
theranostics.
Substantial
studies
commercial
success
"carrier-free"
nanocrystals
have
demonstrated
their
strong
clinical
potential.
However,
practical
translations
remain
challenging
impeded
by
unpredictable
assembly
processes,
insufficient
delivery
efficiency,
an
unclear
in
vivo
fate.
In
this
Perspective,
we
systematically
outline
contemporary
emerging
carrier-free
based
on
diverse
APIs,
well
highlight
opportunities
challenges
translation.
Looking
ahead,
further
improvements
design
preparation,
drug
delivery,
efficacy,
safety
nanomedicines
essential
to
facilitate
translation
from
bench
bedside.
Язык: Английский
Reinforcing Carrier‐Free Photothermal Nanodrugs Through Flavonol‐Driven Assembly
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(37)
Опубликована: Май 15, 2024
Abstract
Carrier‐free
nanodrugs
that
integrate
chemodrugs
and
other
therapeutic
agents
demonstrate
good
efficacy
minimized
side
effects,
showing
promise
for
combined
therapy.
However,
a
key
challenge
lies
in
enhancing
the
bioavailability
potential
of
through
controllable
assembly
process.
Herein,
carrier‐free
photothermal
nanodrug
(ZPQ
NPs)
is
constructed
flavonol‐driven
with
amine‐substituted
perylene
diimide
enhanced
chemo‐photothermal
cancer
The
flavonol,
particularly
quercetin,
facilitates
J‐aggregation
derivatives
within
contributes
to
multiple
improvements,
including
red‐shifted
absorption,
fluorescence
intensity,
improved
conversion
efficiency
as
well
excellent
photostability.
Moreover,
also
demonstrates
cellular
uptake
intracellular
reactive
oxygen
species
scavenging
capability.
combination
quercetin
effect
effectively
kills
cells,
alleviates
inflammation
following
Guided
by
vivo
imaging,
application
ZPQ
NPs
results
complete
tumor
elimination
inhibits
recurrence
This
work
presents
straightforward
strategy
constructing
exhibit
simultaneous
enhancements
both
photophysical
properties
biological
activity.
Язык: Английский
Metabolic reprogramming nanomedicine potentiates colon cancer sonodynamic immunotherapy by inhibiting the CD39/CD73/ADO pathway
Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy
Small,
Год журнала:
2024,
Номер
20(46)
Опубликована: Авг. 6, 2024
Abstract
The
strong
anti‐inflammatory
effect
of
methylprednisolone
(MP)
is
a
necessary
treatment
for
various
severe
cases
including
acute
spinal
cord
injury
(SCI).
However,
concerns
have
been
raised
regarding
adverse
effects
from
MP,
which
also
severely
limits
its
clinical
application.
Natural
polyphenols,
due
to
their
rich
phenolic
hydroxyl
chemical
properties,
can
form
dynamic
structures
without
additional
modification,
achieving
targeted
enrichment
and
drug
release
at
the
disease
lesion,
making
them
highly
promising
carrier.
Considering
application
challenges
natural
polyphenolic
platform
employed
efficient
delivery
reducing
systemic
side
effects.
Both
in
vitro
SCI
models
demonstrated
polyphenols
multiple
advantages
as
carriers
delivering
MP:
(1)
Achieved
maximum
injured
site
2
h
post‐administration,
met
desires
early
diseases;
(2)
Traceless
MP;
(3)
Reducing
effects;
(4)
Endowed
system
with
new
antioxidative
an
aspect
that
needs
be
addressed
diseases
treatment.
This
study
highlighted
prospect
robust
based
on
successfully
overcome
barrier
MP
treatment,
providing
possibility
widespread
Язык: Английский
Dual‐Responsive Shape‐Transformable Charge‐Reversible Nanoparticles Combined with Chemo‐Photodynamic‐Immunotherapy for the Treatment of Breast Cancer and Lung Metastasis
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(48)
Опубликована: Июль 1, 2024
Abstract
Herein,
a
dual‐responsive
shape‐transforming
charge‐reversal
integrated
nanomedicine
system
(DHP@BPP)
is
developed
for
the
co‐delivery
of
photosensitizer
pyro
pheophorbide‐α
(Ppa),
anti‐programmed
cell
death
ligand
1
(PD‐L1)
peptide
(dPPA),
and
tumor‐associated
macrophages
(TAMs)‐regulating
drug
berberrubine
(BBR).
Hydrophobic
Ppa
hydrophilic
BBR
are
linked
by
matrix
metalloproteinase‐2
(MMP‐2)
responsive
(PMGMRKLVFF)
to
form
BPP.
BPP
can
self‐assemble
into
spherical
nanoparticles
with
positive
charge,
which
undergo
shape
transformation
nanofibers
upon
cleavage
MMP‐2
at
tumor
sites.
The
dPPA
conjugated
hexa‐histidine
polyethylene
glycol
DHP,
then
electrostatically
adsorbed
onto
surface
DHP@BPP
negative
charge.
DHP
not
only
enhances
tumor‐targeting
but
also
induces
disassociation
charge
reversal
due
protonation
histidine
site,
thereby
increasing
penetration
while
maintaining
long
blood
circulation.
Most
importantly,
through
combination
chemo‐photodynamic‐immunotherapy,
it
repolarize
TAMs
from
M2‐type
M1‐type
reducing
PD‐L1
expression
reshape
immunosuppressive
microenvironment,
synergistically
enhancing
effect
immunogenic
death.
In
conclusion,
this
study
offered
simple
effective
idea
treatment
cancers
reversal,
integrating
chemo‐photodynamic‐immunotherapy.
Язык: Английский
Engineered Carrier-Free Nanosystem-Induced In Situ Therapeutic Vaccines for Potent Cancer Immunotherapy
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(36), С. 47270 - 47283
Опубликована: Авг. 27, 2024
In
situ
vaccines
that
can
stimulate
tumor
immune
response
have
emerged
as
a
breakthrough
in
antitumor
therapy.
However,
the
immunosuppressed
microenvironment
and
insufficient
infiltration
of
cells
lead
to
ineffective
immunity.
Hence,
biomimetic
carrier-free
nanosystem
(BCC)
induce
synergistic
phototherapy/chemotherapy-driven
was
designed.
A
developed
using
phototherapeutic
reagents
CyI
celastrol
raw
materials.
vitro
vivo
studies
shown
under
NIR
light
irradiation,
BCC-mediated
photo/chemotherapy
not
only
accelerates
release
drugs
deeper
parts
tumors,
achieving
timing
light-controlled
drug
delivery
result
cell
apoptosis,
but
also
effectively
stimulates
vaccine,
which
could
invoke
long-lasting
immunity
inhibit
metastasis
eliminate
distant
tumor.
This
therapeutic
strategy
holds
promise
for
priming
robust
innate
adaptive
responses,
arresting
cancer
progression,
inducing
dormancy.
Язык: Английский
A Modular Approach to Obtain HER2-Targeting DM1-Loaded Nanoparticles for Gastric Cancer Therapy
ACS Omega,
Год журнала:
2024,
Номер
9(49), С. 48598 - 48606
Опубликована: Ноя. 22, 2024
Antibody-based
tumor-targeting
nanomedicines,
despite
their
high
efficacy,
present
significant
challenges
in
preparation
and
long-term
storage.
We
introduce
a
novel
approach
for
the
synthesis
of
durable,
ready-to-use,
antibody-coupled
nanomedical
drugs.
Our
research
centers
on
development
HER2-targeting
DM1-loaded
nanoparticles
gastric
cancer
treatment
using
modular
methodology.
synthesized
Fc-PLG-Mal,
conjugated
DM1
through
"click"
reaction,
subsequently
bound
resultant
compound
with
HER2
antibody
trastuzumab.
The
demonstrated
drug
loading
content,
stable
particle
size,
effective
targeting.
HER2-PLG-DM1
exhibited
cytotoxicity
against
NCI-N87
cells,
an
IC50
0.35
nM.
Biodistribution
revealed
rapid
substantial
tumor
accumulation,
6-fold
higher
than
that
nontargeting
IgG-PLG-DM1.
significantly
inhibited
growth
tumor-bearing
mice,
achieving
90.8%
inhibition
rate,
displayed
dose-dependent
effects
without
liver
kidney
toxicity.
These
studies
offer
efficient
method
Язык: Английский