Easily applicable predictive score for MPR based on parameters before neoadjuvant chemoimmunotherapy in operable NSCLC: a single-center, ambispective, observational study

International Journal of Surgery, Год журнала: 2024, Номер 110(4), С. 2275 - 2287

Опубликована: Янв. 23, 2024

Background: Neoadjuvant chemoimmunotherapy (NACI) is promising for resectable nonsmall cell lung cancer (NSCLC), but predictive biomarkers are still lacking. The authors aimed to develop a model based on pretreatment parameters predict major pathological response (MPR) such an approach. Methods: enrolled operable NSCLC treated with NACI between March 2020 and May 2023 then collected baseline clinical-pathology data routine laboratory examinations before treatment. efficacy safety of this cohort was reported variables were screened by Logistic Lasso regression nomogram developed. In addition, receiver operating characteristic curves, calibration decision curve analysis used assess its power. Finally, internal cross-validation external validation performed the power model. Results: total, 206 eligible patients recruited in study 53.4% (110/206) achieved MPR. Using multivariate analysis, constructed seven variables, prothrombin time (PT), neutrophil percentage (NEUT%), large platelet ratio (P-LCR), eosinophil (EOS%), smoking, type, programmed death ligand-1 (PD-L1) expression finally. had good discrimination, area under (AUC) 0.775, 0.746, 0.835 all datasets, cross-validation, validation, respectively. curves showed consistency, indicated potential value clinical practice. Conclusion: This real world revealed favorable NACI. proposed multiple clinically accessible could effectively MPR probability be powerful tool personalized medication.

Язык: Английский

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Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors

Cancer Epidemiology Biomarkers & Prevention, Год журнала: 2024, Номер 33(6), С. 796 - 803

Опубликована: Март 22, 2024

Abstract Background: Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, poor outcomes in patients with ovarian cancer. No study evaluated the impact of across life-course on infiltration Ig abundance tumors. Methods: We measured markers B plasma cells isotypes using multiplex immunofluorescence 395 cancer tumors Nurses’ Health Study (NHS)/NHSII. conducted beta-binomial analyses evaluating odds ratios (OR) 95% confidence intervals (CI) positivity by cigarette among cases Cox proportional hazards models evaluate hazard (HR) CI developing low (<median) or high (≥median) cell/Ig percentage. Results: There were no associations between IgM Among cases, we observed higher IgA+ ever smokers (OR, 1.54; CI, 1.14–2.07) parental 2.03; 1.18–3.49) versus never smokers. Women not had risk IgG+ (HR, 1.51; 1.10–2.09), whereas a lower 0.74; 0.56–0.99). Conclusions: Ever smoking was associated increased IgA Impact: improved outcomes, suggesting that although is cancer, it may lead tumor immunogenicity.

Язык: Английский

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CCL21 Induces Plasmacytoid Dendritic Cell Migration and Activation in a Mouse Model of Glioblastoma

Cancers, Год журнала: 2024, Номер 16(20), С. 3459 - 3459

Опубликована: Окт. 12, 2024

Dendritic cells (DCs) are professional antigen-presenting that traditionally divided into two distinct subsets: myeloid DCs (mDCs) and plasmacytoid (pDCs). pDCs known for their ability to secrete large amounts of cytokine type I interferons (IFN- α). In our previous work, we have demonstrated pDC infiltration promotes glioblastoma (GBM) tumor immunosuppression through decreased IFN-α secretion via TLR-9 signaling increased suppressive function regulatory T (Tregs) IL-10 secretion, resulting in poor overall outcomes mouse models GBM. Further dissecting the mechanism pDC-mediated GBM immunosuppression, this study, identified CCL21 as highly upregulated by multiple cell lines, which recruit sites CCL21-CCR7 signaling. Furthermore, activated microenvironment intracellular β-arrestin CIITA. Finally, found CCL21-treated directly suppress CD8+ proliferation without affecting differentiation, is considered canonical pathway immunotolerant regulation. Taken together, results show play a multifaced role could be novel therapeutic target overcome immunosuppression.

Язык: Английский

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A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study

Journal of Cardiothoracic Surgery, Год журнала: 2024, Номер 19(1)

Опубликована: Ноя. 8, 2024

Observational studies and experimental evidence have shown that chemokines play important roles in lung cancer development, progression, treatment. However, few examined the causal association between them.

Язык: Английский

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