Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors

Cancer Epidemiology Biomarkers & Prevention, Journal Year: 2024, Volume and Issue: 33(6), P. 796 - 803

Published: March 22, 2024

Abstract Background: Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, poor outcomes in patients with ovarian cancer. No study evaluated the impact of across life-course on infiltration Ig abundance tumors. Methods: We measured markers B plasma cells isotypes using multiplex immunofluorescence 395 cancer tumors Nurses’ Health Study (NHS)/NHSII. conducted beta-binomial analyses evaluating odds ratios (OR) 95% confidence intervals (CI) positivity by cigarette among cases Cox proportional hazards models evaluate hazard (HR) CI developing low (<median) or high (≥median) cell/Ig percentage. Results: There were no associations between IgM Among cases, we observed higher IgA+ ever smokers (OR, 1.54; CI, 1.14–2.07) parental 2.03; 1.18–3.49) versus never smokers. Women not had risk IgG+ (HR, 1.51; 1.10–2.09), whereas a lower 0.74; 0.56–0.99). Conclusions: Ever smoking was associated increased IgA Impact: improved outcomes, suggesting that although is cancer, it may lead tumor immunogenicity.

Language: Английский

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Tertiary lymphoid structure in tumor microenvironment and immunotherapy of lung cancer

Archivos de Bronconeumología, Journal Year: 2024, Volume and Issue: 60, P. S77 - S85

Published: July 27, 2024

Immune checkpoint inhibitors have opened an era of lung cancer therapy. However, a notable disparity exists in the efficacy immunotherapy among individual patients. The tertiary lymphoid structure (TLS) is ectopic lymphocyte aggregation that appears under pathological conditions and primary site action for anti-tumor immunity. It commonly reported presence TLS within tumor microenvironment (TME) relates to favorable clinical prognosis excellent response A thorough understanding its dynamic changes TME has become attractive focus optimizing strategies cancer. In this review, we comprehensively generalize composition, formation, mechanism, detection methods TLS, summarize role immunotherapy. Finally, induction also discussed, which may provide more effective therapeutic

Language: Английский

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CCL21 Induces Plasmacytoid Dendritic Cell Migration and Activation in a Mouse Model of Glioblastoma

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3459 - 3459

Published: Oct. 12, 2024

Dendritic cells (DCs) are professional antigen-presenting that traditionally divided into two distinct subsets: myeloid DCs (mDCs) and plasmacytoid (pDCs). pDCs known for their ability to secrete large amounts of cytokine type I interferons (IFN- α). In our previous work, we have demonstrated pDC infiltration promotes glioblastoma (GBM) tumor immunosuppression through decreased IFN-α secretion via TLR-9 signaling increased suppressive function regulatory T (Tregs) IL-10 secretion, resulting in poor overall outcomes mouse models GBM. Further dissecting the mechanism pDC-mediated GBM immunosuppression, this study, identified CCL21 as highly upregulated by multiple cell lines, which recruit sites CCL21-CCR7 signaling. Furthermore, activated microenvironment intracellular β-arrestin CIITA. Finally, found CCL21-treated directly suppress CD8+ proliferation without affecting differentiation, is considered canonical pathway immunotolerant regulation. Taken together, results show play a multifaced role could be novel therapeutic target overcome immunosuppression.

Language: Английский

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A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 8, 2024

Observational studies and experimental evidence have shown that chemokines play important roles in lung cancer development, progression, treatment. However, few examined the causal association between them.

Language: Английский

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