MFAP3L predicts tumor microenvironment status, molecular subtypes and clinical benefit in patients with bladder cancer DOI Creative Commons

Guoou Xie,

Tiezheng Qi,

Yiyan Yao

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 3, 2024

Bladder cancer (BLCA), ranking as the tenth most prevalent malignancy globally, imposes a substantial public health and socio-economic challenge. Despite ongoing efforts by urologists to identify novel molecular subtypes treatment paradigms, intrinsic heterogeneity of BLCA continues obstruct efficacy current diagnostic therapeutic evaluations, leaving gap in comprehensive management BLCA. This necessitates an in-depth investigation into tumor microenvironment (TME) pivotal molecules like MFAP3L. Our research concentrated on MFAP3L, commencing with pan-cancer analysis its immune profile. We discovered that MFAP3L exhibits significant negative correlation numerous components markers BLCA, trend not observed other types. Within TCGA-BLCA cohort, patients were classified High-MFAP3L Low-MFAP3L groups according their transcript levels. exploration TME delved infiltration, subtype patterns, preferences within these groups. High expression was linked favorable prognoses, luminal subtypes, low inversely associated various characteristics. Additionally, high expressors exhibited diminished checkpoint levels, suggesting enhanced immunotherapy tolerance sensitivity oncogenic pathway targeting. Conversely, correlated poor outcomes, basal increased heightened gene mutation rates, alongside radiotherapy, EGFR-targeted treatments, immunotherapy. Hence, emerges critical yet underexplored offering insights status aiding subtyping decision-making.

Язык: Английский

Multiomics integration unravels genotype‐microbiome interactions shaping the conjunctival transcriptome DOI Creative Commons
Qiaoxing Liang,

Guo‐Wang Lin,

Xiaohu Ding

и другие.

iMetaOmics., Год журнала: 2024, Номер 1(2)

Опубликована: Окт. 14, 2024

Abstract Gene expression is a molecular phenotype shaped by the interplay between genotype and environment. The microbiome represents critical environmental exposure for host. However, genotype‐microbiome interactions (GMIs) shaping host transcriptome remain largely unexplored. Here, we integrated conjunctival multiomics data from 120 pairs of twins to investigate GMIs. We identified 272,972 quantitative trait loci associated with 5946 genes 241,073 genotype‐controlled correlations gene microbial abundance. developed modeling approach, MicroGenix, that screens GMIs genome, transcriptome, identifies disease through gene‐based association tests. applied MicroGenix set found incorporating into prediction models significantly increased accuracy. accuracy were overrepresented those encoding cell adhesion molecules. further used predict metagenomes ocular surface disease. Our work provides resource studying host‐microbiome at conjunctiva computational approach using data.

Язык: Английский

Процитировано

0
MFAP3L predicts tumor microenvironment status, molecular subtypes and clinical benefit in patients with bladder cancer DOI Creative Commons

Guoou Xie,

Tiezheng Qi,

Yiyan Yao

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 3, 2024

Bladder cancer (BLCA), ranking as the tenth most prevalent malignancy globally, imposes a substantial public health and socio-economic challenge. Despite ongoing efforts by urologists to identify novel molecular subtypes treatment paradigms, intrinsic heterogeneity of BLCA continues obstruct efficacy current diagnostic therapeutic evaluations, leaving gap in comprehensive management BLCA. This necessitates an in-depth investigation into tumor microenvironment (TME) pivotal molecules like MFAP3L. Our research concentrated on MFAP3L, commencing with pan-cancer analysis its immune profile. We discovered that MFAP3L exhibits significant negative correlation numerous components markers BLCA, trend not observed other types. Within TCGA-BLCA cohort, patients were classified High-MFAP3L Low-MFAP3L groups according their transcript levels. exploration TME delved infiltration, subtype patterns, preferences within these groups. High expression was linked favorable prognoses, luminal subtypes, low inversely associated various characteristics. Additionally, high expressors exhibited diminished checkpoint levels, suggesting enhanced immunotherapy tolerance sensitivity oncogenic pathway targeting. Conversely, correlated poor outcomes, basal increased heightened gene mutation rates, alongside radiotherapy, EGFR-targeted treatments, immunotherapy. Hence, emerges critical yet underexplored offering insights status aiding subtyping decision-making.

Язык: Английский

Процитировано

0