International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 4681 - 4699
Опубликована: Окт. 1, 2024
Thyroid cancer is the most common malignant endocrine tumor, with papillary thyroid carcinoma (PTC) being prevalent type, accounting for 85% of cases. Here, we conducted a bibliometric analysis literature in field microRNAs PTC research to demonstrate current trends and hotspots, present visual map past emerging trends.
Язык: Английский
Biomedicines, Год журнала: 2025, Номер 13(1), С. 203 - 203
Опубликована: Янв. 15, 2025
The link between inflammation and cancer has been extensively studied over the years. While inflammatory process can facilitate tumor establishment progression, on other hand, current clinical approaches aim to boost immune system against mass. In this scenario, conventional chemotherapy proven induce immunogenic cell death in that release of danger-associated alarmins foster cytotoxic immunity following blockade checkpoints. activate inflammasome pathway. Thus, one questions is as follows: anti-tumor drugs lead activation? And if so, resulting effect anti- or pro-tumor? review, we provide an overview role cancer.
Язык: Английский
Процитировано
0
Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 18, 2025
Neoantigen-based cancer vaccine therapy represents a promising precision oncology strategy that targets unique tumor-specific mutations to elicit robust immune response. This therapeutic approach is designed harness the host’s response against neoantigens eliminate cells. The efficacy of neoantigen vaccines dependents on coordinated action diverse cells, including T lymphocytes, dendritic B natural killer and macrophages. Each cell type plays distinct crucial role in recognizing, targeting, destroying malignant Understanding mechanisms governing both individual collective dynamics for success. comprehensive review systematically explores neoantigen-specific their dynamic interactions, clinical application progress, aiming unveil potential value future development treatment.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 24, 2025
Introduction Bovine mastitis causes a significant loss to the dairy industry by affecting quantity and quality of milk. Addressing this challenge, present study will leverage advanced omics techniques for early detection in lactating Sahiwal cows ( Bos indicus ). This was first differential transcriptomic investigating alterations gene expression milk somatic cells during progression naturally occurring indigenous cows. Methods Cows were grouped into healthy (H), subclinical (SCM) clinical (CM) groups thoroughly screening them using California Mastitis Test (CMT) cell counts (SCC). followed detailed composition analysis, leukocyte (DLC), microbiological culture. Results The SCs through transcriptome profiling identified 83 76, up-regulated 157 192 down-regulated genes CM vs H SCM (log2 fold change ≥1 ≤-1, p < 0.05) respectively. Pathway analysis revealed that upregulated enriched pathways such as phagosome activity, IL-17 signalling, Th1 Th2 differentiation, while downregulated linked RIG-I-like receptor NK cytotoxicity, Toll-like signalling Cytokine-cytokine interactions. Notably, underscores roles chemokines CCL8, CCL2, CXCL10 immune recruitment mastitis, where their downregulation suggests impaired mammary defense governs Chemokine pathways. Further, comparative with previously available proteome data mastitis. Discussion Overall, research enhances our understanding pathogenesis emphasizes these targeted may boost resilience immunomodulation, genetic selection genome editing or utilising adjuvants vaccine development restore chemokine offers potential strategy improve resistance cattle.
Язык: Английский
Процитировано
0
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 765 - 765
Опубликована: Июль 18, 2024
T cells are essential tumor suppressors in cancer immunology, but their dysfunction induced by can result cell exhaustion. Exhausted (Tex) significantly influence the immune environment, and thus, there is a need for thorough investigation across different types of cancer. Here, we address role Tex pan-cancer, focusing on expression, mutations, methylation, infiltration, drug sensitivity molecular signature comprising genes HAVCR2, CXCL13, LAG3, LAYN, TIGIT, PDCD1across multiple types, using bioinformatics analysis TCGA data. Our revealed that differentially expressed 14 being correlated with patient survival outcomes, distinct trends. Pathway indicated key cancer-related pathways, such as apoptosis, EMT, DNA damage pathways. Immune infiltration highlighted positive correlation between gene expression bladder cancer, while mutations these were associated specific enrichments UCEC SKCM. CNVs widespread cancers. We also highlight high LAYN methylation most tumors negative levels various Drug identified numerous correlations, CXCL13 HAVCR2 expressions influencing to several drugs, including Apitolisib, Belinostat, Docetaxel. Overall, findings importance reviving exhausted enhance treatment efficacy boost anti-tumor immunity achieve better clinical outcomes.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136391 - 136391
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 18, 2024
Breast cancer (BC) remains a significant health issue globally and most common cause of mortality in women. Enhancing our understanding on biomarkers may greatly improve both diagnostic therapeutic approaches to this disease.
Язык: Английский
Процитировано
1
International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 4681 - 4699
Опубликована: Окт. 1, 2024
Thyroid cancer is the most common malignant endocrine tumor, with papillary thyroid carcinoma (PTC) being prevalent type, accounting for 85% of cases. Here, we conducted a bibliometric analysis literature in field microRNAs PTC research to demonstrate current trends and hotspots, present visual map past emerging trends.
Язык: Английский
Процитировано
0