ICSP «NEW SCIENCE» eBooks, Год журнала: 2023, Номер unknown
Опубликована: Янв. 1, 2023
МЦНП «НОВАЯ НАУКА» ЧРЕЗКОЖНАЯ СТИМУЛЯЦИЯ БЛУЖДАЮЩЕГО
Язык: Русский
Disability and Rehabilitation, Год журнала: 2024, Номер 46(24), С. 5730 - 5760
Опубликована: Фев. 16, 2024
Transcutaneous auricular vagus nerve stimulation (taVNS) is an emerging non-invasive neuromodulation therapy. This study aimed to explore the therapeutic use of taVNS, optimal parameters, effective sham protocols, and safety.
Язык: Английский
Процитировано
16
Physiological Reports, Год журнала: 2025, Номер 13(3)
Опубликована: Фев. 1, 2025
Abstract Emerging evidence suggests that the vagus nerve can modulate immune system in experimental settings. Vagus stimulation (VNS), initially developed for managing epilepsy, is now being explored as a treatment autoimmune diseases due to its potential immunomodulatory effects. This systematic review evaluates therapeutic of VNS by critically appraising findings from human clinical studies. was conducted accordance with PRISMA guideline, comprehensive literature search performed Ovid, Cochrane, and PubMed databases up July 2024. Studies focusing on patients were eligible, quality study assessed using QualSyst tool. Of 53 papers identified full‐text assessment, 19 studies met eligibility criteria. Findings suggest promising adjunctive therapy Crohn's disease rheumatoid arthritis, showing alleviate symptoms responses. The efficacy safety vary widely across studies, highlighting complex nature diverse mechanisms action. Future research should prioritize large‐scale, randomized controlled trials standardized protocols further elucidate efficacy, long‐term safety, optimal parameters various conditions.
Язык: Английский
Процитировано
1
Clinical Autonomic Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 4, 2024
Язык: Английский
Процитировано
7
PAIN Reports, Год журнала: 2024, Номер 9(5), С. e1171 - e1171
Опубликована: Авг. 7, 2024
Chronic pain is one of the major causes disability with a tremendous impact on an individual's quality life and public health. Transcutaneous vagus nerve stimulation (tVNS) safe therapeutic for this condition. We aimed to evaluate its effects in adults chronic pain. A comprehensive search was performed, including randomized controlled trials published until October 2023, which assessed noninvasive tVNS. Cohen's
Язык: Английский
Процитировано
6
Expert Review of Clinical Immunology, Год журнала: 2024, Номер 20(6), С. 603 - 622
Опубликована: Фев. 26, 2024
Systemic sclerosis (SSc) is a connective tissue disease with heterogeneous presentation. Gastrointestinal (GI) complications of SSc are characterized by esophageal reflux, abnormal motility, and microbiome dysbiosis, which impact patient quality life mortality. Preventative therapeutics lacking, management primarily aimed at symptomatic control.
Язык: Английский
Процитировано
4
Therapeutic Apheresis and Dialysis, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
Abstract Introduction Transcutaneous auricular vagus nerve stimulation (tVNS) has shown potential in neurological, autoimmune, and cardiovascular disorders, but its effects on HD patients remain unclear. This study aimed to evaluate the efficacy safety of tVNS patients. Methods We conducted a randomized controlled clinical trial receiving ≥6 months. The group received for 1 h during first 2 sessions, three times weekly 8 weeks, while control standard care. primary outcomes were dialysis efficiency (Single‐pool Kt/V, Sp Kt/V) dialysis‐related symptoms (Dialysis Symptom Index, DSI), assessed every 4 weeks. Secondary included pain fatigue scores, physical performance, Hemodialysis Comfort Scale, hemoglobin levels, Mini‐Mental State Examination, anxiety depression measured at baseline weeks after intervention. Results A total 63 enrolled study, with 32 assigned 31 group. At showed significant improvements Kt/V (1.31 ± 0.11 vs. 1.25 0.10, p = 0.02), DSI (12.09 5.84 16.26 5.27, 0.004), as well reductions fatigue, increases function, comfort, hemoglobin. However, there no statistically changes observed cognitive anxiety, or depression. Conclusions could improve efficiency, symptoms, function patients, indicating it may have role complementary therapy.
Язык: Английский
Процитировано
0
Cognitive Neurodynamics, Год журнала: 2025, Номер 19(1)
Опубликована: Янв. 24, 2025
Язык: Английский
Процитировано
0
Neuromodulation Technology at the Neural Interface, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
The number of randomized controlled trials (RCTs) using auricular stimulation (AS) techniques, such as transauricular vagus nerve stimulation, electrostimulation, acupuncture, and acupressure in experimental clinical settings has increased markedly over the last three decades. This systematic review evaluates effects AS on biomarkers inflammation stress responses. following data bases were searched: MEDLINE (PubMed), EMBASE, Cochrane Central Register Controlled Trials (CENTRAL), ISI Web Science, Scopus Data base. collection analysis conducted independently by two reviewers. Quality risk assessments included studies performed, a meta-analysis most frequently assessed was RevMan statistical software. A total 1122 patients healthy volunteers from 27 RCTs this review; 81% participants female, with median age 51 years. Pooled 18 showed significant effect regarding reduction serum C-reactive protein, tumor necrosis factor-α, interleukin (IL)-6, IL-10. Although IL-4, IL1β, cortisol, substance P calcitonin gene-related peptide, adrenocorticotropic hormone did not show any changes, salivary amylase under AS. influence inflammatory cytokines seems to be mediated More research is needed investigate immunologic system addition its significance high-quality RCT.
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(4), С. 499 - 499
Опубликована: Март 29, 2025
Patients with type 2 diabetes mellitus (T2DM) predominantly experience mortality due to cardiovascular diseases (CVD), particularly in low- and middle-income nations. Among these, heart failure (HF) is the most severe complication terms of prognosis management. Despite advancements individualized glycemic control risk management, including development novel glucose- lipid-lowering agents, prevalence HF T2DM patients remains persistently high. This indicates that factors beyond hyperglycemia significantly contribute heightened associated T2DM. review examines critical influencing CVD T2DM, roles reduced rate variability (HRV), a marker autonomic dysfunction, chronic inflammation, both which play pivotal pathogenesis. Recent evidence highlights potential vagus nerve activation modulate these factors, underscoring its capacity reduce T2DM-related complications. Specifically, we discuss therapeutic promise transcutaneous auricular stimulation (taVNS) as non-invasive intervention enhance vagal tone, decrease systemic improve outcomes By addressing interplay among HRV, microvascular disease, this provides comprehensive perspective on utility taVNS managing
Язык: Английский
Процитировано
0
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Ноя. 13, 2024
Non-invasive vagus nerve stimulation (VNS) represents a transformative approach for managing broad spectrum of inflammatory and autoimmune conditions, including rheumatoid arthritis bowel disease. This comprehensive review delineates the mechanisms underlying VNS, emphasizing cholinergic anti-inflammatory pathway, explores interactions within neuro-immune vagus-gut axes based on both clinical outcomes pre-clinical models. Clinical applications have confirmed efficacy VNS in specific diseases, such as arthritis, chronic conditions like disease, showcasing variability parameters patient responses. Concurrently, studies provided insights into potential modulating cardiovascular broader responses, paving way its translational application settings. Innovations non-invasive technology precision neuromodulation are enhancing therapeutic potential, making it viable option patients who unresponsive to conventional treatments. Nonetheless, widespread adoption this promising therapy is impeded by regulatory challenges, compliance issues, need extensive long-term safety. Future research directions will focus refining technology, optimizing treatment parameters, exploring synergistic effects with other modalities, which could revolutionize management disorders.
Язык: Английский
Процитировано
3