Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients DOI
Xiaoxiao Sun, Meijuan Li,

Yuying Qiu

и другие.

Schizophrenia Research, Год журнала: 2024, Номер 274, С. 457 - 463

Опубликована: Ноя. 7, 2024

Язык: Английский

Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia DOI
Karin Huizer, Shubham Soni,

M. Schmidt

и другие.

Psychiatry Research, Год журнала: 2025, Номер 345, С. 116379 - 116379

Опубликована: Янв. 29, 2025

Язык: Английский

Процитировано

1
Morphological alterations of the thymus gland in individuals with schizophrenia DOI
Qiannan Zhao, Wei Xia,

Wei Yu

и другие.

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

0
Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress DOI
Silvia Alboni, Fabio Tascedda, Akihito Uezato

и другие.

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

0
Nucleus Accumbens Proteome Disbalance in an Adolescent Mouse Model of Schizophrenia and Nicotine Misuse Comorbidity DOI Creative Commons
Thainá P. Souza, Andrés Rodríguez-Vega, Ana Carolina Dutra-Tavares

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 901 - 901

Опубликована: Апрель 8, 2025

Background/Objectives: Schizophrenia and nicotine misuse are a comorbid condition that frequently develops during adolescence. Considering the role of nucleus accumbens (NAcc) as common neurobiological substrate for these psychiatric disorders, label-free proteomics was employed to identify NAcc deregulated proteins in male female mouse models schizophrenia with history adolescent exposure. Methods: Phencyclidine used model schizophrenia, minipump infusions were misuse. Results: Enrichment Reactome pathway protein–protein interaction analyses showed cytoskeleton associated synaptic plasticity mechanisms, energy metabolism, nervous system development affected both sexes. In particular, Ncam1 (Neural cell adhesion molecule 1) could be interest candidate marker disbalance. Its deregulation sexes suggests it lies at core comorbidity pathophysiology. When considering sex-selective effects, Cs (Citrate synthase) Mapk3 (Mitogen-activated protein kinase 3) identified exclusively mice, respectively. Since previously shown medial prefrontal cortex co-modeled mesocortical mesolimbic effect can inferred, supporting aberrant metabolism model. Conclusions: The current data provide insights into proteome disbalance an preclinical combined misuse, pointing relevant pathways early markers comorbidity.

Язык: Английский

Процитировано

0
Evaluating Microglial Dysfunction and Psychiatric Illness by Exploring the Inflammatory Basis of Schizophrenia and Depression in Cross-Sectional Study settings DOI Open Access
Shahid Hussain,

Noor-e-Hira Memon,

Fahad ul Zain

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Risperidone accelerates bone loss in mice models of schizophrenia by inhibiting osteoblast autophagy DOI Creative Commons

Zaihong Yang,

Peifan Li,

Fan Hongyan

и другие.

Heliyon, Год журнала: 2024, Номер 10(21), С. e38559 - e38559

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

1
A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia DOI Creative Commons

Huan Yu,

Rui Li,

Xue‐jun Liang

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 20, 2024

Major depressive disorder (MDD) and schizophrenia (SCH) are common severe mental disorders that mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers can distinguish these two diseases is still meaningful. In present study, we investigate differences in plasma inflammatory cytokines short-chain fatty acids (SCFAs) among patients with MDD (n = 24) SCH 24), gender- age-matched healthy controls (HC, n 27) identify biomarkers. We found concentrations of pro-inflammatory were increased, whereas anti-inflammatory decreased both SCH. Meanwhile, except for an increase 4-Methylvaleric acid, other SCFAs statistical reduced Moreover, biomarker panels developed effectively discriminate from HC (AUC 0.997), 0.999), each (MDD SCH, AUC 0.983). These data suggest alterations might be one features distinguishing Chinese Clinical Trial Registry: ChiCTR2100051243, registration date: 2021/09/16.

Язык: Английский

Процитировано

1
Lack of Efficacy of Simvastatin Adjunctive Therapy for Patients with Schizophrenia: A Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Junyu Chen,

Yu‐Pei Yuan,

Ying Hu

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 1667 - 1675

Опубликована: Сен. 1, 2024

The adjunctive therapeutic potential of simvastatin in schizophrenia treatment has generated interest due to its anti-inflammatory and neuroprotective properties. This meta-analysis aims assess the efficacy as an adjunct for schizophrenia, synthesizing results from various controlled trials.

Язык: Английский

Процитировано

0
Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients DOI
Xiaoxiao Sun, Meijuan Li,

Yuying Qiu

и другие.

Schizophrenia Research, Год журнала: 2024, Номер 274, С. 457 - 463

Опубликована: Ноя. 7, 2024

Язык: Английский

Процитировано

0