Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients DOI
Xiaoxiao Sun, Meijuan Li,

Yuying Qiu

et al.

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 274, P. 457 - 463

Published: Nov. 7, 2024

Language: Английский

Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia DOI
Karin Huizer, Shubham Soni,

M. Schmidt

et al.

Psychiatry Research, Journal Year: 2025, Volume and Issue: 345, P. 116379 - 116379

Published: Jan. 29, 2025

Language: Английский

Citations

1
Morphological alterations of the thymus gland in individuals with schizophrenia DOI
Qiannan Zhao, Wei Xia,

Wei Yu

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress DOI
Silvia Alboni, Fabio Tascedda, Akihito Uezato

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Nucleus Accumbens Proteome Disbalance in an Adolescent Mouse Model of Schizophrenia and Nicotine Misuse Comorbidity DOI Creative Commons
Thainá P. Souza, Andrés Rodríguez-Vega, Ana Carolina Dutra-Tavares

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 901 - 901

Published: April 8, 2025

Background/Objectives: Schizophrenia and nicotine misuse are a comorbid condition that frequently develops during adolescence. Considering the role of nucleus accumbens (NAcc) as common neurobiological substrate for these psychiatric disorders, label-free proteomics was employed to identify NAcc deregulated proteins in male female mouse models schizophrenia with history adolescent exposure. Methods: Phencyclidine used model schizophrenia, minipump infusions were misuse. Results: Enrichment Reactome pathway protein–protein interaction analyses showed cytoskeleton associated synaptic plasticity mechanisms, energy metabolism, nervous system development affected both sexes. In particular, Ncam1 (Neural cell adhesion molecule 1) could be interest candidate marker disbalance. Its deregulation sexes suggests it lies at core comorbidity pathophysiology. When considering sex-selective effects, Cs (Citrate synthase) Mapk3 (Mitogen-activated protein kinase 3) identified exclusively mice, respectively. Since previously shown medial prefrontal cortex co-modeled mesocortical mesolimbic effect can inferred, supporting aberrant metabolism model. Conclusions: The current data provide insights into proteome disbalance an preclinical combined misuse, pointing relevant pathways early markers comorbidity.

Language: Английский

Citations

0
Evaluating Microglial Dysfunction and Psychiatric Illness by Exploring the Inflammatory Basis of Schizophrenia and Depression in Cross-Sectional Study settings DOI Open Access
Shahid Hussain,

Noor-e-Hira Memon,

Fahad ul Zain

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Risperidone accelerates bone loss in mice models of schizophrenia by inhibiting osteoblast autophagy DOI Creative Commons

Zaihong Yang,

Peifan Li,

Fan Hongyan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e38559 - e38559

Published: Sept. 27, 2024

Language: Английский

Citations

1
A cross-section study of the comparison of plasma inflammatory cytokines and short-chain fatty acid in patients with depression and schizophrenia DOI Creative Commons

Huan Yu,

Rui Li,

Xue‐jun Liang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 20, 2024

Major depressive disorder (MDD) and schizophrenia (SCH) are common severe mental disorders that mainly diagnosed depending on the subjective identification by psychiatrists. Finding potential objective biomarkers can distinguish these two diseases is still meaningful. In present study, we investigate differences in plasma inflammatory cytokines short-chain fatty acids (SCFAs) among patients with MDD (n = 24) SCH 24), gender- age-matched healthy controls (HC, n 27) identify biomarkers. We found concentrations of pro-inflammatory were increased, whereas anti-inflammatory decreased both SCH. Meanwhile, except for an increase 4-Methylvaleric acid, other SCFAs statistical reduced Moreover, biomarker panels developed effectively discriminate from HC (AUC 0.997), 0.999), each (MDD SCH, AUC 0.983). These data suggest alterations might be one features distinguishing Chinese Clinical Trial Registry: ChiCTR2100051243, registration date: 2021/09/16.

Language: Английский

Citations

1
Lack of Efficacy of Simvastatin Adjunctive Therapy for Patients with Schizophrenia: A Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Junyu Chen,

Yu‐Pei Yuan,

Ying Hu

et al.

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 1667 - 1675

Published: Sept. 1, 2024

The adjunctive therapeutic potential of simvastatin in schizophrenia treatment has generated interest due to its anti-inflammatory and neuroprotective properties. This meta-analysis aims assess the efficacy as an adjunct for schizophrenia, synthesizing results from various controlled trials.

Language: Английский

Citations

0
Plasma NGAL, not IFN-γ, predicts early treatment response in drug-naïve Chinese Han schizophrenia patients DOI
Xiaoxiao Sun, Meijuan Li,

Yuying Qiu

et al.

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 274, P. 457 - 463

Published: Nov. 7, 2024

Language: Английский

Citations

0