Molecular Neurodegeneration,
Год журнала:
2023,
Номер
18(1)
Опубликована: Июнь 5, 2023
Abstract
Peripheral
inflammation,
defined
as
inflammation
that
occurs
outside
the
central
nervous
system,
is
an
age-related
phenomenon
has
been
identified
a
risk
factor
for
Alzheimer’s
disease.
While
role
of
chronic
peripheral
well
characterized
in
context
dementia
and
other
conditions,
less
known
about
neurologic
contribution
acute
inflammatory
insults
take
place
system.
Herein,
we
define
immune
challenge
form
pathogen
exposure
(e.g.,
viral
infection)
or
tissue
damage
surgery)
causes
large,
yet
time-limited,
response.
We
provide
overview
clinical
translational
research
examined
connection
between
disease,
focusing
on
three
categories
have
received
considerable
attention
recent
years:
infection,
critical
illness,
surgery.
Additionally,
review
neurobiological
mechanisms
which
facilitate
neural
response
to
discuss
potential
blood–brain
barrier
components
neuro-immune
axis
After
highlighting
knowledge
gaps
this
area
research,
propose
roadmap
address
methodological
challenges,
suboptimal
study
design,
paucity
transdisciplinary
efforts
thus
far
limited
our
understanding
how
pathogen-
damage-mediated
may
contribute
Finally,
therapeutic
approaches
designed
promote
resolution
be
used
following
preserve
brain
health
limit
progression
neurodegenerative
pathology.
Molecular Neurodegeneration,
Год журнала:
2022,
Номер
17(1)
Опубликована: Март 5, 2022
The
implication
of
gut
microbiota
in
the
control
brain
functions
health
and
disease
is
a
novel,
currently
emerging
concept.
Accumulating
data
suggest
that
exert
its
action
at
least
part
by
modulating
neuroinflammation.
Given
link
between
neuroinflammatory
changes
neuronal
activity,
it
plausible
may
affect
indirectly
impacting
microglia,
key
player
Indeed,
increasing
evidence
suggests
interplay
microglia
synaptic
dysfunction
involve
microbiota,
among
other
factors.
In
addition
to
these
indirect
microglia-dependent
actions
on
has
been
recently
recognized
could
also
activity
directly
stimulation
vagus
nerve.
Nature Reviews Gastroenterology & Hepatology,
Год журнала:
2024,
Номер
21(4), С. 222 - 247
Опубликована: Фев. 14, 2024
Crosstalk
between
gut
and
brain
has
long
been
appreciated
in
health
disease,
the
microbiota
is
a
key
player
communication
these
two
distant
organs.
Yet,
mechanisms
through
which
influences
development
function
of
gut–brain
axis
remain
largely
unknown.
Barriers
present
are
specialized
cellular
interfaces
that
maintain
strict
homeostasis
different
compartments
across
this
axis.
These
barriers
include
epithelial
barrier,
blood–brain
barrier
blood–cerebrospinal
fluid
barrier.
ideally
positioned
to
receive
communicate
microbial
signals
constituting
gateway
for
gut–microbiota–brain
communication.
In
Review,
we
focus
on
how
modulation
by
can
constitute
an
important
channel
Moreover,
malfunction
upon
alterations
composition
could
form
basis
various
conditions,
including
often
comorbid
neurological
gastrointestinal
disorders.
Thus,
should
unravelling
molecular
move
from
simplistic
framing
as
'leaky
gut'.
A
mechanistic
understanding
barriers,
especially
during
critical
windows
development,
be
aetiology
The
modulator
This
Review
provides
overview
examines
role
disease.
Annual Review of Neuroscience,
Год журнала:
2022,
Номер
45(1), С. 425 - 445
Опубликована: Апрель 18, 2022
Mounting
evidence
indicates
that
microglia,
which
are
the
resident
immune
cells
of
brain,
play
critical
roles
in
a
diverse
array
neurodevelopmental
processes
required
for
proper
brain
maturation
and
function.
This
has
ultimately
led
to
growing
speculation
microglial
dysfunction
may
role
disorder
(NDD)
pathoetiology.
In
this
review,
we
first
provide
an
overview
how
microglia
mechanistically
contribute
sculpting
developing
neuronal
circuits.
To
example
disruption
biology
impacts
NDD
development,
also
highlight
emerging
linked
dysregulation
autism
spectrum
pathogenesis.
recent
years,
there
been
increasing
interest
gut
microbiome
shapes
biology.
last
section
put
spotlight
on
burgeoning
area
research
discuss
microbiota-dependent
modulation
is
currently
thought
influence
progression.
