Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Опубликована: Фев. 26, 2025
Due to the burden of infectious diseases, human life expectancy at birth remained about 20–25 years until end 19th century, implying that host defense—which operates individual level, and only poorly that—is barely sufficient population level. Microbes preceded us by three billion evolve much more rapidly. Moreover, protective immunity has been selected evolutionary cost allergy, autoinflammation, autoimmunity. It is therefore no exaggeration predict almost all humans carry inborn errors immunity, with insufficient or excessive responses some environmental triggers, otherwise. Thanks remarkable power its concepts recent progress in methods, genetics finally made it possible investigate mechanisms molecular cellular levels. Human provide countless opportunities analyze derailments natural conditions, an unprecedented scale, are thus a unique asset from both biological medical perspectives. Hence, Journal Immunity.
Язык: Английский
Процитировано
3The Journal of Experimental Medicine, Год журнала: 2024, Номер 221(12)
Опубликована: Ноя. 1, 2024
Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne (TBE, TBE [TBEV]) (∼10%). We report here that these auto-Abs also severe forms rarer arboviral infections. Auto-Abs high concentrations IFN-α2, IFN-β, and/or IFN-ω present in the single case Powassan (POWV) studied, two three cases Usutu (USUV) infection most 24 Ross River (RRV) disease studied. These not found any 137 individuals with silent or mild infections viruses. Thus, IFNs an increasing list Flaviviridae (WNV, TBEV, POWV, USUV) Togaviridae viruses transmitted humans by mosquitos USUV, RRV) ticks (TBEV, POWV).
Язык: Английский
Процитировано
6Nature, Год журнала: 2024, Номер 635(8039), С. 563 - 573
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
6iScience, Год журнала: 2024, Номер 27(9), С. 110731 - 110731
Опубликована: Авг. 23, 2024
Pioneering studies linking symptomatic disease and cough-mediated
Язык: Английский
Процитировано
5Nature, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
5Human Genomics, Год журнала: 2025, Номер 19(1)
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0Current Opinion in Rheumatology, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Whipple's disease (WD), triggered by Tropheryma whipplei ( T. ), is a rare, chronic, inflammatory, systemic infectious that typically manifests in adults. The most frequent initial manifestations include arthritis, followed diarrhea, abdominal pain, and weight loss. Half the world's population exposed to , but only one million develop WD. This suggests acquired or inborn errors of immunity (IEI) may underlie Anti-TNF treatment well established risk factor for flare-ups We have also reported two rare IEI patients with Six WD from unrelated kindreds were found autosomal dominant IRF4 deficiency acting via mechanism haploinsufficiency. These otherwise healthy. In addition, single patient history other infections was recessive CD4 deficiency. Rare can Human genetic studies are warranted development precision medicine affected improve our understanding pathogenesis this disease.
Язык: Английский
Процитировано
0The Microbe, Год журнала: 2025, Номер unknown, С. 100347 - 100347
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Immunological Reviews, Год журнала: 2024, Номер unknown
Опубликована: Сен. 28, 2024
Summary Enteric viruses are the main cause of acute gastroenteritis worldwide with a significant morbidity and mortality, especially among children aged adults. Some enteric also disseminated infections severe neurological manifestations such as poliomyelitis. Protective immunity against these is not well understood in humans, most knowledge coming from animal models, although development poliovirus rotavirus vaccines has extended our knowledge. In classical view, innate involves recognition foreign DNA or RNA by pathogen receptors leading to production interferons other inflammatory cytokines. Antigen uptake presentation T cells B then activate adaptive and, case mucosal immunity, induce secretion dimeric IgA, more potent immunoglobulins viral neutralization. The study Inborn errors (IEIs) offers natural opportunity nonredundant toward pathogens. viruses, patients defective antibodies at risk developing complications. Moreover, recent description low absent antibody protracted associated hepatitis reinforces prominent role control virus.
Язык: Английский
Процитировано
2Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
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