Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Published: Feb. 26, 2025
Due to the burden of infectious diseases, human life expectancy at birth remained about 20–25 years until end 19th century, implying that host defense—which operates individual level, and only poorly that—is barely sufficient population level. Microbes preceded us by three billion evolve much more rapidly. Moreover, protective immunity has been selected evolutionary cost allergy, autoinflammation, autoimmunity. It is therefore no exaggeration predict almost all humans carry inborn errors immunity, with insufficient or excessive responses some environmental triggers, otherwise. Thanks remarkable power its concepts recent progress in methods, genetics finally made it possible investigate mechanisms molecular cellular levels. Human provide countless opportunities analyze derailments natural conditions, an unprecedented scale, are thus a unique asset from both biological medical perspectives. Hence, Journal Immunity.
Language: Английский
Citations
3The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(12)
Published: Nov. 1, 2024
Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne (TBE, TBE [TBEV]) (∼10%). We report here that these auto-Abs also severe forms rarer arboviral infections. Auto-Abs high concentrations IFN-α2, IFN-β, and/or IFN-ω present in the single case Powassan (POWV) studied, two three cases Usutu (USUV) infection most 24 Ross River (RRV) disease studied. These not found any 137 individuals with silent or mild infections viruses. Thus, IFNs an increasing list Flaviviridae (WNV, TBEV, POWV, USUV) Togaviridae viruses transmitted humans by mosquitos USUV, RRV) ticks (TBEV, POWV).
Language: Английский
Citations
6Nature, Journal Year: 2024, Volume and Issue: 635(8039), P. 563 - 573
Published: Nov. 20, 2024
Language: Английский
Citations
6iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110731 - 110731
Published: Aug. 23, 2024
Pioneering studies linking symptomatic disease and cough-mediated
Language: Английский
Citations
5Nature, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 20, 2024
Language: Английский
Citations
5Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)
Published: Jan. 30, 2025
Language: Английский
Citations
0Current Opinion in Rheumatology, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Whipple's disease (WD), triggered by Tropheryma whipplei ( T. ), is a rare, chronic, inflammatory, systemic infectious that typically manifests in adults. The most frequent initial manifestations include arthritis, followed diarrhea, abdominal pain, and weight loss. Half the world's population exposed to , but only one million develop WD. This suggests acquired or inborn errors of immunity (IEI) may underlie Anti-TNF treatment well established risk factor for flare-ups We have also reported two rare IEI patients with Six WD from unrelated kindreds were found autosomal dominant IRF4 deficiency acting via mechanism haploinsufficiency. These otherwise healthy. In addition, single patient history other infections was recessive CD4 deficiency. Rare can Human genetic studies are warranted development precision medicine affected improve our understanding pathogenesis this disease.
Language: Английский
Citations
0The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100347 - 100347
Published: April 1, 2025
Language: Английский
Citations
0Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 28, 2024
Summary Enteric viruses are the main cause of acute gastroenteritis worldwide with a significant morbidity and mortality, especially among children aged adults. Some enteric also disseminated infections severe neurological manifestations such as poliomyelitis. Protective immunity against these is not well understood in humans, most knowledge coming from animal models, although development poliovirus rotavirus vaccines has extended our knowledge. In classical view, innate involves recognition foreign DNA or RNA by pathogen receptors leading to production interferons other inflammatory cytokines. Antigen uptake presentation T cells B then activate adaptive and, case mucosal immunity, induce secretion dimeric IgA, more potent immunoglobulins viral neutralization. The study Inborn errors (IEIs) offers natural opportunity nonredundant toward pathogens. viruses, patients defective antibodies at risk developing complications. Moreover, recent description low absent antibody protracted associated hepatitis reinforces prominent role control virus.
Language: Английский
Citations
2Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
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