Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Янв. 31, 2019
Abstract
Antimicrobial
resistance
is
a
global
health
crisis
and
few
novel
antimicrobials
have
been
discovered
in
recent
decades.
Natural
products,
particularly
from
Streptomyces
,
are
the
source
of
most
antimicrobials,
yet
discovery
campaigns
focusing
on
soil
largely
rediscover
known
compounds.
Investigation
understudied
symbiotic
sources
has
seen
some
success,
no
studies
systematically
explored
microbiomes
for
antimicrobials.
Here
we
assess
distinct
evolutionary
lineages
insect
as
new
through
large-scale
isolations,
bioactivity
assays,
genomics,
metabolomics,
vivo
infection
models.
Insect-associated
inhibit
antimicrobial-resistant
pathogens
more
than
.
Genomics
metabolomics
reveal
their
diverse
biosynthetic
capabilities.
Further,
describe
cyphomycin,
molecule
active
against
multidrug
resistant
fungal
pathogens.
The
trajectories
microbiome
influence
potential
ability
to
pathogens,
supporting
promise
this
augmenting
future
antimicrobial
discovery.
Abstract
Background
Microbial-driven
decomposition
of
plant
residues
is
integral
to
carbon
sequestration
in
terrestrial
ecosystems.
Actinobacteria
,
one
the
most
widely
distributed
bacterial
phyla
soils,
are
known
for
their
ability
degrade
vitro.
However,
situ
importance
and
specific
activity
across
contrasting
ecological
environments
not
known.
Here,
we
conducted
three
field
experiments
with
buried
straw
combination
microcosm
13
C-straw
paddy
soils
under
different
soil
fertility
levels
reveal
ecophysiological
roles
residue
decomposition.
Results
While
accounting
only
4.6%
total
abundance,
encoded
16%
abundance
carbohydrate-active
enzymes
(CAZymes).
The
taxonomic
functional
compositions
were,
surprisingly,
relatively
stable
during
Slopes
linear
regression
models
between
chemical
composition
Actinobacterial
traits
were
flatter
than
those
other
groups
at
both
local
regional
scales
due
holding
genes
encoding
full
set
CAZymes,
nitrogenases,
antibiotic
synthetases.
Ecological
co-occurrence
network
C-based
metagenomic
analyses
indicated
that
degradation
increased
less
fertile
as
links
community
members
relative
abundances
decreasing
fertility.
Conclusions
This
study
provided
DNA-based
evidence
non-dominant
plays
a
key
role
possess
high
proportions
CAZymes
group
maintain
presence
terms
roles.
Their
was
more
pronounced
where
possession
interspecies
interactions
stood
out
more.
Our
work
provides
new
angles
understanding
global
cycling.
Biotechnology for Biofuels,
Год журнала:
2021,
Номер
14(1)
Опубликована: Янв. 6, 2021
Abstract
The
issues
of
global
warming,
coupled
with
fossil
fuel
depletion,
have
undoubtedly
led
to
renewed
interest
in
other
sources
commercial
fuels.
search
for
renewable
fuels
has
motivated
research
into
the
biological
degradation
lignocellulosic
biomass
feedstock
produce
biofuels
such
as
bioethanol,
biodiesel,
and
biohydrogen.
model
strain
biofuel
production
needs
capability
utilize
a
high
amount
substrate,
transportation
sugar
through
fast
deregulated
pathways,
ability
tolerate
inhibitory
compounds
end
products,
increased
metabolic
fluxes
an
improved
fermentation
product.
Engineering
microbes
might
be
great
approach
from
by
exploiting
pathways
economically.
Metabolic
engineering
is
advanced
technology
construction
highly
effective
microbial
cell
factories
key
component
next-generation
bioeconomy.
It
been
extensively
used
redirect
biosynthetic
pathway
desired
products
several
native
or
engineered
hosts.
A
wide
range
novel
manufactured
endogenous
metabolism
optimizations
engineers.
This
review
focused
on
potential
utilization
strains
gives
prospects
improvement
new
development
using
technologies.
The ISME Journal,
Год журнала:
2021,
Номер
16(1), С. 296 - 306
Опубликована: Июль 28, 2021
Abstract
Microbial
communities
play
important
roles
in
all
ecosystems
and
yet
a
comprehensive
understanding
of
the
ecological
processes
governing
assembly
these
is
missing.
To
address
role
biotic
interactions
between
microorganisms
for
functioning
soil
microbiota,
we
used
top-down
manipulation
approach
based
on
removal
various
populations
natural
microbial
community.
We
hypothesized
that
certain
groups
will
strongly
affect
relative
fitness
many
others,
therefore
unraveling
contribution
shaping
microbiome.
Here
show
39%
dominant
bacterial
taxa
across
treatments
were
subjected
to
competitive
during
recolonization,
highlighting
importance
soil.
Moreover,
our
allowed
identification
community
rule
as
exemplified
by
exclusion
members
Bacillales
Proteobacteriales.
Modified
resulted
greater
changes
activities
related
N-
than
C-cycling.
Our
can
provide
new
promising
avenue
study
complex
well
links
composition
ecosystem
function.
Marine Drugs,
Год журнала:
2021,
Номер
19(7), С. 365 - 365
Опубликована: Июнь 25, 2021
The
Actinomycetales
order
is
one
of
great
genetic
and
functional
diversity,
including
diversity
in
the
production
secondary
metabolites
which
have
uses
medical,
environmental
rehabilitation,
industrial
applications.
Secondary
produced
by
actinomycete
species
are
an
abundant
source
antibiotics,
antitumor
agents,
anthelmintics,
antifungals.
These
actinomycete-derived
medicines
circulation
as
current
treatments,
but
actinomycetes
also
being
explored
potential
sources
new
compounds
to
combat
multidrug
resistance
pathogenic
bacteria.
Actinomycetes
a
solve
concerns
another
area
recent
investigation,
particularly
their
utility
bioremediation
pesticides,
toxic
metals,
radioactive
wastes,
biofouling.
Other
applications
include
biofuels,
detergents,
food
preservatives/additives.
Exploring
other
unique
properties
will
allow
for
deeper
understanding
this
interesting
taxonomic
group.
Combined
with
engineering,
microbial
experimental
evolution,
enhancement
techniques,
it
reasonable
assume
that
use
marine
continue
increase.
Novel
products
begin
be
developed
diverse
applied
research
purposes,
zymology
enology.
This
paper
outlines
knowledge
usage
research,
focusing
on
isolates
providing
direction
future
research.
Plant Stress,
Год журнала:
2023,
Номер
10, С. 100242 - 100242
Опубликована: Сен. 29, 2023
As
climate
change
exacerbates
drought
conditions,
global
crop
production
faces
an
escalating
threat.
Fortunately,
eco-friendly
solution
lies
in
harnessing
the
potential
of
plant-associated
plant
growth-promoting
bacteria.
However,
it's
crucial
to
recognize
that
drought's
impact
extends
beyond
plants;
it
also
influences
composition,
abundance,
and
activity
bacterial
communities.
Amongst
these
root-associated
communities,
Actinobacteria
are
key
players
preserving
well-being
hosts
during
stress,
with
research
demonstrating
minimal
disruption
communities
under
conditions.
Actinobacteria,
found
ubiquitously,
exceptional
candidates
for
promoting
growth
due
their
prevalence
soil
rhizosphere,
adeptness
at
colonizing
roots
surfaces,
capability
produce
diverse
secondary
metabolites
stress.
With
attributes,
members
phylum
present
themselves
as
most
promising
microbial
inoculation
plants.
They
enriched
rhizosphere
endosphere
microbiomes
crops
enduring
water
deficit
stress
Notably,
particularly
Streptomyces
genus,
employ
various
mechanisms,
such
modulation
phytohormone
levels,
reinforcement
antioxidant
enzymes,
enhanced
nutrient
uptake,
more,
alleviate
crops.
This
comprehensive
review
explores
actinobacterial
diversity
associated
plants
delves
into
on
Actinobacteria.
It
examines
mechanisms
through
which
mitigate
Emphasizing
role
multi-omics
techniques
broadening
our
understanding
plant-Actinobacteria
interactions,
this
aims
inspire
further
exploration
relatively
uncharted
territory.
Furthermore,
discusses
future
directions
application
traits,
underlining
sustainable
agricultural
practices.
Applied Microbiology and Biotechnology,
Год журнала:
2018,
Номер
102(17), С. 7219 - 7230
Опубликована: Июнь 21, 2018
Actinobacteria,
a
large
group
of
Gram-positive
bacteria,
secrete
wide
range
extracellular
enzymes
involved
in
the
degradation
organic
compounds
and
biopolymers
including
ubiquitous
aminopolysaccharides
chitin
chitosan.
While
chitinolytic
are
distributed
all
kingdoms
life,
actinobacteria
recognized
as
particularly
good
decomposers
chitinous
material
several
members
this
taxon
carry
impressive
sets
genes
dedicated
to
chitosan
degradation.
Degradation
these
polymers
is
dependent
on
endo-
exo-acting
hydrolases
well
lytic
polysaccharide
monooxygenases.
Actinobacterial
chitinases
chitosanases
belong
nine
major
families
glycosyl
that
share
no
sequence
similarity.
In
paper,
distribution
within
different
ecosystems
examined
their
machinery
described
compared
those
other
organisms.
