Biological Psychiatry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Pest Management Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 11, 2025
Abstract BACKGROUND The whitefly Bemisia tabaci is a notorious agricultural pest known for its ability to cause significant crop damage through direct feeding and virus transmission. Its remarkable adaptability reproductive capacity are linked acquire integrate horizontally transferred genes (HTGs) into genome. These HTGs increase the physiological metabolic capacities of this pest, including cholesterol synthesis, which critical survival success. Among these genes, we identified plant‐derived B. Δ7‐sterol C5‐desaturase‐like gene ( BtSC5DL ), plays pivotal role in metabolism biology. RESULTS In study, cloned from Mediterranean (MED). Bioinformatics molecular analyses revealed that was plants millions years ago now stably expressed species. Silencing dsRNA resulted reductions egg production content MED. Furthermore, virus‐induced silencing (VIGS) experiments confirmed long‐term suppression had notable control populations. CONCLUSION Our results demonstrate crucial biosynthesis MED suggest acquisition significantly enhances findings provide theoretical basis development RNA interference (RNAi)‐based strategies targeting , offering potential new approach effective management populations settings. © 2025 Society Chemical Industry.
Язык: Английский
Процитировано
2
Nature reviews. Immunology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Язык: Английский
Процитировано
14
Nature Reviews Neurology, Год журнала: 2023, Номер 19(10), С. 583 - 598
Опубликована: Авг. 29, 2023
Язык: Английский
Процитировано
19
Biomolecules, Год журнала: 2024, Номер 14(4), С. 410 - 410
Опубликована: Март 28, 2024
Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both genetic nongenetic mechanisms. Hundreds chemicals that we are exposed to in our daily lives alter sterol biosynthesis. These also encompass various classes FDA-approved medications, including (but not limited to) commonly used antipsychotic, antidepressant, antifungal, cardiovascular medications. medications interfere with enzymes the post-lanosterol biosynthetic pathway, giving rise complex biochemical changes throughout body. The consequences these short- long-term homeostatic disruptions mostly unknown. We performed a comprehensive review literature built catalogue chemical agents capable inhibiting This process identified significant gaps existing knowledge, which fall into two main areas: mechanisms biosynthesis altered arise from inhibitions different steps pathway. outcome reinforced inhibition often-overlooked mechanism result adverse there need develop new safety guidelines for use (novel already approved) side effects, especially during pregnancy.
Язык: Английский
Процитировано
6
Cell & Bioscience, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 13, 2023
Abstract Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating effect statins on lowering cholesterol suggest that there may be link between levels AD pathology. Since one most abundant lipid molecules, especially brain tissue, it affects membrane-related processes, including formation dangerous form amyloid β, Aβ42. The entire Aβ production system, which includes precursor protein (APP), β-secretase, complex γ-secretase, highly dependent membrane content. Moreover, can affect amyloidogenesis many ways. Cholesterol influences stability activity secretases, but also dictates their partitioning into specific cellular compartments cholesterol-enriched rafts, where amyloidogenic machinery predominantly localized. complicated relationships have been found interaction APP, not only APP localization precise character dimerization processing by important for different lengths . In this review, we describe intricate web interdependence levels, distribution, cholesterol-dependent Aβ, major AD.
Язык: Английский
Процитировано
14
Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 162, С. 105724 - 105724
Опубликована: Май 16, 2024
Alzheimer's disease (AD) is prevalent around the world, yet our understanding of still very limited. Recent work suggests that cornerstone AD may include inflammation accompanies it. Failure a normal pro-inflammatory immune response to resolve lead persistent central contributes unsuccessful clearance amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress other factors contributing greater risk developing AD. Here, we integrate evidence for interface between these factors, how contribute brain milieu. In particular, discuss importance appropriate polyunsaturated fatty acids (PUFA) in diet metabolism specialised pro-resolving mediators (SPMs); raising possibility strategies improve outlook.
Язык: Английский
Процитировано
5
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to four-generation family with familiar (FPD) is identified. In this study, whole exome sequencing (WES) genetic linkage analysis across lineage presenting six cases of FPD are conducted. A disease-causing in identified for FPD. Further analyses reveal consistent correlation between expression downregulation PD occurrence, chondrocyte degeneration, OA onset. Moreover, ABCA6-KO mice demonstrate severe knee joint degeneration accelerated progression. Besides, synovial mesenchymal stem cells (SMSCs) extracted from WT, ABCA6-/+, ABCA6-/- create chondrogenic organoids vitro, confirming deficiency lead via modulating cell cycle activating cellular senescence. transcriptome metabolomic on chondrocytes unveils that the inhibits cholesterol efflux, leading intracellular accumulation senescence impaired chondrogenesis.A correlated occurrence serve as potential target chondrogenesis treatment by orchestrated efflux delayed
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер 994, С. 177388 - 177388
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
0
Frontiers in Ophthalmology, Год журнала: 2024, Номер 3
Опубликована: Янв. 3, 2024
Cholesterol is an essential component of cellular membranes, crucial for maintaining their structural and functional integrity. It especially important nervous tissues, including the retina, which rely on high amounts plasma membranes transmission signal. While cholesterol by far most abundant sterol, retina also contains precursors metabolites, oxysterols, are bioactive molecules. lack or excess deleterious some oxysterols known effect neuron survival. homeostasis must therefore be maintained. Retinal glial cells, Müller principal cells vertebrate provide mechanical, nutritional, metabolic support neighboring neurons. Several pieces evidence indicate that major actors in as it other brain. This process based a close cooperation with neurons, sterols can signaling molecules participating glia-neuron interactions. implication age-related macular degeneration now recognized, epidemiological laboratory data, its role glaucoma still scarce. The association between cholesterolemia controversial, but experimental data suggest could take part pathological processes. has been demonstrated implicated development through ambivalent reactive retinal gliosis process. early steps contribute to favor survival ganglion targeted during glaucoma. If persists, dysregulation neuroprotective functions, cytotoxic effects gliotic disruption interactions lead acceleration cell death. Sterols play response glaucomatous injury. represents understudied attractive topic better understand conceive novel preventive curative strategies. present review describes current knowledge i) sterol metabolism ii) potential glaucoma, iii) possible relationships Focus put
Язык: Английский
Процитировано
4
Advances in microbial physiology/Advances in Microbial Physiology, Год журнала: 2024, Номер unknown, С. 83 - 133
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
4