Biochemical Markers as Predictors of Health Outcomes in Autism Spectrum Disorder: A Comprehensive Systematic Review and Meta-analysis
Journal of Molecular Neuroscience,
Год журнала:
2025,
Номер
75(1)
Опубликована: Фев. 6, 2025
Язык: Английский
Sterol biosynthesis disruption by common prescription medications: critical implications for neural development and brain health
Brain medicine :,
Год журнала:
2025,
Номер
unknown, С. 1 - 6
Опубликована: Фев. 25, 2025
Sterol
biosynthesis
is
essential
for
cellular
function,
producing
not
only
cholesterol
but
also
critical
bioactive
molecules
that
regulate
cell
signaling,
growth,
and
membrane
function.
In
the
brain,
metabolism
operates
independently
behind
blood–brain
barrier,
maintaining
its
own
homeostatic
balance.
An
emerging
concern
in
clinical
pharmacology
discovery
many
common
prescription
drugs
unintentionally
interfere
with
post-lanosterol
sterol
synthesis
pathways.
While
acute
effects
of
these
medications
are
documented,
their
long-term
consequences
brain
development
function
remain
unclear.
Studies
using
cultures
mouse
models
indicate
heightened
risk
during
pregnancy,
where
drug-induced
disruption
may
interact
genetic
factors
from
both
mother
fetus,
particularly
when
multiple
prescribed.
This
significant
research
gap
has
important
implications
practice.
Our
review
consolidates
current
evidence
about
how
affect
outlines
areas
requiring
urgent
investigation.
Язык: Английский
Inhibition of post-lanosterol biosynthesis by fentanyl: potential implications for Fetal Fentanyl Syndrome (FFS)
Molecular Psychiatry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 6, 2024
Язык: Английский
Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1435 - 1435
Опубликована: Ноя. 11, 2024
Sterol
biosynthesis
is
a
crucial
metabolic
pathway
in
plants
and
various
plant
pathogens.
Their
vital
physiological
role
multicellular
organisms
their
effects
on
growth
reproduction
underline
importance
as
membrane
compounds,
hormone
precursors,
signaling
molecules.
Insects,
nematodes,
oomycetes
of
the
Peronosporales
group,
which
harbor
important
agricultural
pests
pathogens,
have
lost
ability
to
synthesize
own
sterols.
These
rely
acquisition
sterols
from
host
are
dependent
sterol
composition
host.
It
thought
that
sterol-synthesizing
enzymes
were
during
co-evolution
with
hosts,
provided
sufficient
amounts
required
To
meet
essential
requirements
these
organisms,
some
auxotrophs
retained
few
remaining
sterol-modifying
enzymes.
Several
molecular
biochemical
investigations
suggested
promising
avenues
for
pest
pathogen
control
by
targeting
composition,
uptake,
or
modification
biosynthesize
de
novo.
This
review
examines
loss
novo
insects,
aim
investigating
constraints
organisms.
will
shed
light
its
potential
target
management
sterol-dependent
comprehensive
agronomic
approach.
Язык: Английский
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins
Archives of Toxicology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
Abstract
Toxic
fungal
secondary
metabolites,
referred
to
as
mycotoxins,
emerge
in
moldy
food
and
feed
constitute
a
potent
but
often
underestimated
health
threat
for
humans
animals.
They
are
structurally
diverse
can
cause
diseases
after
dietary
intake
even
low
concentrations.
To
elucidate
cellular
responses
identify
targets
of
bottom-up
proteomics
approach
was
used.
We
investigated
the
effects
mycotoxins
aflatoxin
B
1
,
ochratoxin
A,
citrinin,
deoxynivalenol,
nivalenol
penitrem
A
on
human
hepatoblastoma
cell
line
HepG2
citrinin
kidney
epithelial
IHKE.
Incubations
were
carried
out
at
sub-cytotoxic
concentrations
monitor
molecular
before
acute
death
mechanisms
predominate.
Through
these
experiments,
we
able
detect
specific
that
point
towards
mycotoxins’
mode
action.
Besides
very
well-described
like
ribotoxicity
trichothecenes,
observed
not
yet
described
different
mechanisms.
For
instance,
trichothecenes
lowered
apolipoprotein
abundance
affected
proteins
related
inflammation,
ribogenesis
mitosis.
Ochratoxin
upregulated
minichromosomal
maintenance
complex
nucleotide
synthesis
downregulated
histones
Penitrem
reduced
enzyme
levels
sterol
biosynthesis.
These
results
will
aid
elucidation
toxicodynamic
properties
this
highly
relevant
class
toxins.
Язык: Английский
The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production
Metabolites,
Год журнала:
2024,
Номер
14(12), С. 711 - 711
Опубликована: Дек. 18, 2024
Mitochondrial
metabolism
plays
a
pivotal
role
in
regulating
the
synthesis
of
secondary
metabolites,
which
are
crucial
for
survival
and
adaptation
organisms.
These
metabolites
synthesized
during
specific
growth
stages
or
response
to
environmental
stress,
reflecting
organism’s
ability
adapt
changing
conditions.
Mitochondria,
while
primarily
known
their
energy
production,
directly
regulate
metabolite
biosynthesis
by
providing
essential
precursor
molecules,
energy,
reducing
equivalents
necessary
metabolic
reactions.
Furthermore,
they
indirectly
influence
through
intricate
signaling
pathways,
including
reactive
oxygen
species
(ROS),
redox
signaling,
modulate
various
processes.
This
review
explores
recent
advances
understanding
molecular
mechanisms
governing
mitochondrial
regulatory
roles
biosynthesis,
highlights
involvement
transcription
factors,
small
RNAs,
post-translational
modifications
shaping
these
By
integrating
current
insights,
it
aims
inspire
future
research
into
Arabidopsis
thaliana,
Solanum
tuberosum,
Nicotiana
tabacum,
others
that
may
enhance
production.
A
deeper
mitochondria
could
contribute
development
new
approaches
biotechnology
applications.
Язык: Английский