Colorectal cancer

The Lancet, Год журнала: 2019, Номер 394(10207), С. 1467 - 1480

Опубликована: Окт. 1, 2019

Язык: Английский

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Cancer stem cells revisited

Nature Medicine, Год журнала: 2017, Номер 23(10), С. 1124 - 1134

Опубликована: Окт. 1, 2017

Язык: Английский

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EMT Transition States during Tumor Progression and Metastasis

Trends in Cell Biology, Год журнала: 2018, Номер 29(3), С. 212 - 226

Опубликована: Дек. 26, 2018

Язык: Английский

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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Genes & Diseases, Год журнала: 2018, Номер 5(2), С. 77 - 106

Опубликована: Май 12, 2018

As the most commonly occurring cancer in women worldwide, breast poses a formidable public health challenge on global scale. Breast consists of group biologically and molecularly heterogeneous diseases originated from breast. While risk factors associated with this varies respect to other cancers, genetic predisposition, notably mutations

Язык: Английский

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Visualization and targeting of LGR5+ human colon cancer stem cells

Nature, Год журнала: 2017, Номер 545(7653), С. 187 - 192

Опубликована: Март 27, 2017

Язык: Английский

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Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Proceedings of the National Academy of Sciences, Год журнала: 2019, Номер 116(18), С. 9020 - 9029

Опубликована: Апрель 17, 2019

Significance The exclusion of immune cells from the tumor microenvironment has been associated with poor prognosis in majority cancers. We report that when considering 21 solid cancer types, cell is widely presence a stem cell-like phenotype tumors (“stemness”). Stemness positively correlates higher intratumoral heterogeneity, possibly by protecting antigenic clones elimination system. activation stemness program appears to limit antitumor responses via cell-intrinsic silencing endogenous retrovirus expression, repression type I interferon signaling, and up-regulation immunosuppressive checkpoints. Our work suggests targeting will promote T infiltration render more responsive control.

Язык: Английский

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Cellular Plasticity in Cancer

Cancer Discovery, Год журнала: 2019, Номер 9(7), С. 837 - 851

Опубликована: Апрель 16, 2019

Abstract During cancer progression, tumor cells undergo molecular and phenotypic changes collectively referred to as cellular plasticity. Such result from microenvironmental cues, stochastic genetic epigenetic alterations, and/or treatment-imposed selective pressures, thereby contributing heterogeneity therapy resistance. Epithelial–mesenchymal plasticity is the best-known case of cell plasticity, but recent work has uncovered other examples, often with functional consequences. In this review, we explore nature role(s) these diverse programs in premalignant evolution, adaptation consider ways which targeting could lead novel anticancer treatments. Significance: Changes identity, or are common at different stages it become clear that can be a potent mediator progression chemoresistance. Understanding mechanisms underlying various forms may deliver new strategies for most lethal aspects cancer: metastasis resistance therapy.

Язык: Английский

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Cancer stem cells: The root of tumor recurrence and metastases

Seminars in Cancer Biology, Год журнала: 2017, Номер 44, С. 10 - 24

Опубликована: Март 1, 2017

Язык: Английский

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PI3K inhibitors are finally coming of age

Nature Reviews Drug Discovery, Год журнала: 2021, Номер 20(10), С. 741 - 769

Опубликована: Июнь 14, 2021

Язык: Английский

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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

Stem Cells International, Год журнала: 2017, Номер 2017, С. 1 - 17

Опубликована: Янв. 1, 2017

Stemness combines the ability of a cell to perpetuate its lineage, give rise differentiated cells, and interact with environment maintain balance between quiescence, proliferation, regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer (CSCs) behave as their malignant equivalents. CSCs stemness various circumstances, including sustaining cancer progression, interaction search for key survival factors. As result, can recurrently persist after therapy. In order understand how concept applies cancer, this review will explore shared normal Cells. First, we provide an overview We thereafter elaborate on features operate CSCs. then organization microenvironment components, which enables hosting. subsequently discuss Mesenchymal Stem/Stromal (MSCs), which, although are limited, represent essential components Cell niche tumor microenvironment. next insights therapeutic strategies targeting tumors use state-of-the-art techniques future research. Increasing our knowledge is identifying new solutions.

Язык: Английский

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