Colorectal cancer

The Lancet, Journal Year: 2019, Volume and Issue: 394(10207), P. 1467 - 1480

Published: Oct. 1, 2019

Language: Английский

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Cancer stem cells revisited

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(10), P. 1124 - 1134

Published: Oct. 1, 2017

Language: Английский

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EMT Transition States during Tumor Progression and Metastasis

Trends in Cell Biology, Journal Year: 2018, Volume and Issue: 29(3), P. 212 - 226

Published: Dec. 26, 2018

Language: Английский

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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Genes & Diseases, Journal Year: 2018, Volume and Issue: 5(2), P. 77 - 106

Published: May 12, 2018

As the most commonly occurring cancer in women worldwide, breast poses a formidable public health challenge on global scale. Breast consists of group biologically and molecularly heterogeneous diseases originated from breast. While risk factors associated with this varies respect to other cancers, genetic predisposition, notably mutations

Language: Английский

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Visualization and targeting of LGR5+ human colon cancer stem cells

Nature, Journal Year: 2017, Volume and Issue: 545(7653), P. 187 - 192

Published: March 27, 2017

Language: Английский

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Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(18), P. 9020 - 9029

Published: April 17, 2019

Significance The exclusion of immune cells from the tumor microenvironment has been associated with poor prognosis in majority cancers. We report that when considering 21 solid cancer types, cell is widely presence a stem cell-like phenotype tumors (“stemness”). Stemness positively correlates higher intratumoral heterogeneity, possibly by protecting antigenic clones elimination system. activation stemness program appears to limit antitumor responses via cell-intrinsic silencing endogenous retrovirus expression, repression type I interferon signaling, and up-regulation immunosuppressive checkpoints. Our work suggests targeting will promote T infiltration render more responsive control.

Language: Английский

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Cellular Plasticity in Cancer

Cancer Discovery, Journal Year: 2019, Volume and Issue: 9(7), P. 837 - 851

Published: April 16, 2019

Abstract During cancer progression, tumor cells undergo molecular and phenotypic changes collectively referred to as cellular plasticity. Such result from microenvironmental cues, stochastic genetic epigenetic alterations, and/or treatment-imposed selective pressures, thereby contributing heterogeneity therapy resistance. Epithelial–mesenchymal plasticity is the best-known case of cell plasticity, but recent work has uncovered other examples, often with functional consequences. In this review, we explore nature role(s) these diverse programs in premalignant evolution, adaptation consider ways which targeting could lead novel anticancer treatments. Significance: Changes identity, or are common at different stages it become clear that can be a potent mediator progression chemoresistance. Understanding mechanisms underlying various forms may deliver new strategies for most lethal aspects cancer: metastasis resistance therapy.

Language: Английский

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Cancer stem cells: The root of tumor recurrence and metastases

Seminars in Cancer Biology, Journal Year: 2017, Volume and Issue: 44, P. 10 - 24

Published: March 1, 2017

Language: Английский

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PI3K inhibitors are finally coming of age

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(10), P. 741 - 769

Published: June 14, 2021

Language: Английский

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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

Stem Cells International, Journal Year: 2017, Volume and Issue: 2017, P. 1 - 17

Published: Jan. 1, 2017

Stemness combines the ability of a cell to perpetuate its lineage, give rise differentiated cells, and interact with environment maintain balance between quiescence, proliferation, regeneration. While adult Stem Cells display these properties when participating in tissue homeostasis, Cancer (CSCs) behave as their malignant equivalents. CSCs stemness various circumstances, including sustaining cancer progression, interaction search for key survival factors. As result, can recurrently persist after therapy. In order understand how concept applies cancer, this review will explore shared normal Cells. First, we provide an overview We thereafter elaborate on features operate CSCs. then organization microenvironment components, which enables hosting. subsequently discuss Mesenchymal Stem/Stromal (MSCs), which, although are limited, represent essential components Cell niche tumor microenvironment. next insights therapeutic strategies targeting tumors use state-of-the-art techniques future research. Increasing our knowledge is identifying new solutions.

Language: Английский

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