Nutrients,
Год журнала:
2018,
Номер
10(5), С. 645 - 645
Опубликована: Май 19, 2018
Novel
and
alternative
options
are
being
adopted
to
combat
the
initiation
progression
of
human
cancers.
One
approaches
is
use
molecules
isolated
from
traditional
medicinal
herbs,
edible
dietary
plants
seeds
that
play
a
pivotal
role
in
prevention/treatment
cancer,
either
alone
or
combination
with
existing
chemotherapeutic
agents.
Compounds
modulate
these
oncogenic
processes
potential
candidates
for
cancer
therapy
may
eventually
make
it
clinical
applications.
Diosgenin
naturally
occurring
steroidal
sapogenin
one
major
bioactive
compounds
found
fenugreek
(Trigonella
foenum-graecum)
seeds.
In
addition
lactation
aid,
diosgenin
has
been
shown
be
hypocholesterolemic,
gastro-
hepato-protective,
anti-oxidant,
anti-inflammatory,
anti-diabetic,
anti-cancer.
unique
structural
similarity
estrogen.
Several
preclinical
studies
have
reported
on
pro-apoptotic
anti-cancer
properties
against
variety
cancers,
both
vitro
vivo.
also
reverse
multi-drug
resistance
cells
sensitize
standard
chemotherapy.
Remarkably,
used
by
pharmaceutical
companies
synthesize
drugs.
novel
analogs
nano-formulations
synthesized
improved
efficacy
pharmacokinetic
profile.
this
review
we
discuss
detail
multifaceted
application
pharmaceutical,
functional
food,
cosmetic
industries;
various
intracellular
molecular
targets
modulated
abrogate
process.
Genes & Diseases,
Год журнала:
2018,
Номер
5(2), С. 77 - 106
Опубликована: Май 12, 2018
As
the
most
commonly
occurring
cancer
in
women
worldwide,
breast
poses
a
formidable
public
health
challenge
on
global
scale.
Breast
consists
of
group
biologically
and
molecularly
heterogeneous
diseases
originated
from
breast.
While
risk
factors
associated
with
this
varies
respect
to
other
cancers,
genetic
predisposition,
notably
mutations
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2016,
Номер
11(1), С. 47 - 76
Опубликована: Май 19, 2016
Different
mechanisms
contribute
to
intratumor
heterogeneity,
including
genetic
mutations,
the
microenvironment,
and
existence
of
subpopulations
cancer
cells
with
increased
renewal
capacity
ability
recapitulate
heterogeneity
found
in
primary
tumors,
which
are
referred
as
stem
(CSCs).
In
this
review,
we
discuss
how
concept
CSCs
has
been
defined,
what
assays
currently
used
define
functional
properties
CSCs,
intrinsic
extrinsic
regulate
CSC
functions,
plastic
are,
importance
epithelial-to-mesenchymal
transition
conferring
properties.
Finally,
by
may
resist
medical
therapy
tumor
relapse.
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2011,
Номер
9(1), С. 1 - 25
Опубликована: Март 2, 2011
Glioblastoma
(GBM)
is
one
of
the
most
lethal
human
cancers.
Genomic
analyses
are
defining
molecular
architecture
GBM,
uncovering
relevant
subsets
patients
whose
disease
may
require
different
treatments.
Many
pharmacological
targets
have
been
revealed,
promising
to
transform
patient
care
through
targeted
therapies.
However,
for
patients,
clinical
responses
inhibitors
either
not
apparent
or
durable.
In
this
review,
we
address
challenge
developing
more
effective,
molecularly
guided
approaches
treatment
GBM
patients.
We
summarize
current
state
knowledge
regarding
classifiers
and
examine
their
benefit
stratifying
treatment.
survey
landscape
disease,
discussing
challenges
raised
by
acquired
drug
resistance.
Furthermore,
analyze
biochemical
features
suggesting
a
next
generation
targets,
contribution
tumor
heterogeneity
its
implications.
conclude
with
an
analysis
experimental
potential
Breast
cancer
is
a
heterogeneous
disease
and
differs
greatly
among
different
patients
(intertumor
heterogeneity)
even
within
each
individual
tumor
(intratumor
heterogeneity).
Clinical
morphologic
intertumor
heterogeneity
reflected
by
staging
systems
histopathologic
classification
of
breast
cancer.
Heterogeneity
in
the
expression
established
prognostic
predictive
biomarkers,
hormone
receptors
HER2
oncoprotein,
basis
for
targeted
treatment.
Molecular
classifications
are
indicators
genetic
heterogeneity,
which
probed
with
multigene
assays
can
lead
to
improved
stratification
into
low
high
risk
groups
personalized
therapy.
Intratumor
occurs
at
morphologic,
genomic,
transcriptomic
proteomic
levels,
creating
diagnostic
therapeutic
challenges.
Understanding
molecular
cellular
mechanisms
that
relevant
development
treatment
resistance
major
area
research.
Despite
knowledge
complex
phenotypic
features
underpinning
there
has
been
only
limited
advancement
diagnostic,
or
strategies
The
current
guidelines
reporting
biomarkers
aim
maximize
patient
eligibility
therapy,
but
do
not
take
account
intratumor
heterogeneity.
implemented
routine
clinical
practice.
Additional
studies
in-depth
analysis
required
understand
significance
rapidly
accumulating
data.
This
review
highlights
inter-
carcinoma
special
emphasis
on
pathologic
findings,
provides
insights
Systematic Biology,
Год журнала:
2014,
Номер
64(1), С. e1 - e25
Опубликована: Окт. 7, 2014
Cancer
is
a
somatic
evolutionary
process
characterized
by
the
accumulation
of
mutations,
which
contribute
to
tumor
growth,
clinical
progression,
immune
escape,
and
drug
resistance
development.
Evolutionary
theory
can
be
used
analyze
dynamics
cell
populations
make
inference
about
history
from
molecular
data.
We
review
recent
approaches
modeling
evolution
cancer,
including
population
models
initiation
phylogenetic
methods
model
relationship
between
subclones,
probabilistic
graphical
describe
dependencies
among
mutations.
helps
understand
how
tumors
arise
will
also
play
an
increasingly
important
prognostic
role
in
predicting
disease
progression
outcome
medical
interventions,
such
as
targeted
therapy.
