Molecular Endocrinology,
Год журнала:
2005,
Номер
19(9), С. 2371 - 2379
Опубликована: Май 26, 2005
Pituitary
tumor
transforming
gene
(Pttg)
is
induced
in
pituitary
tumors
and
associated
with
increased
invasiveness.Pttg-null
mice
do
not
develop
tumors,
but
exhibit
hypoplasia,
while
heterozygous
for
the
retinoblastoma
(Rb)
deletion
high
penetrance.Pttg-null
were
therefore
cross-bred
Rb
+/-mice
to
test
impact
of
hypoplasia
on
development.Prior
development,
+/-Pttg
-/-mice
have
smaller
glands
fewer
cycling
cells
induction
p21
levels.Pttg
silencing
vitro
specific
shRNAi
AtT20
mouse
corticotrophs
led
a
marked
mRNA
protein
levels,
decreased
RB
phosphorylation,
subsequent
24%
decrease
S-phase
cells.Eighty
six
percent
+/+
adenomas
by
13
months,
contrast
30%
double-crossed
-/-animals
(P<0.01).Pituitary
suppressed
cell
proliferation,
prevents
penetrance
+/-animals,
protective
determinant
tumorigenesis.
Science,
Год журнала:
2003,
Номер
299(5603), С. 117 - 120
Опубликована: Янв. 2, 2003
Neurogenesis
occurs
in
the
olfactory
system
of
adult
brain
throughout
life,
both
invertebrates
and
vertebrates,
but
its
physiological
regulation
is
not
understood.
We
show
that
production
neuronal
progenitors
stimulated
forebrain
subventricular
zone
female
mice
during
pregnancy
this
effect
mediated
by
hormone
prolactin.
The
then
migrate
to
produce
new
interneurons,
a
process
likely
be
important
for
maternal
behavior,
because
discrimination
critical
recognition
rearing
offspring.
even
females
mate
with
sterile
males.
These
findings
imply
neurogenesis
may
contribute
adaptive
behaviors
mating
pregnancy.
Endocrine Reviews,
Год журнала:
2007,
Номер
28(1), С. 117 - 149
Опубликована: Фев. 1, 2007
The
corpus
luteum
(CL)
is
one
of
the
few
endocrine
glands
that
forms
from
remains
another
organ
and
whose
function
survival
are
limited
in
scope
time.
CL
site
rapid
remodeling,
growth,
differentiation,
death
cells
originating
granulosa,
theca,
capillaries,
fibroblasts.
apparent
raison
d’etre
production
progesterone,
all
structural
functional
features
this
gland
geared
toward
end.
Because
its
unique
importance
for
successful
pregnancies,
mammals
have
evolved
a
complex
series
checks
balances
maintains
progesterone
at
appropriate
levels
throughout
gestation.
formation,
maintenance,
regression,
steroidogenesis
among
most
significant
closely
regulated
events
mammalian
reproduction.
During
pregnancy,
fate
depends
on
interplay
ovarian,
pituitary,
placental
regulators.
At
end
life
span,
undergoes
process
regression
leading
to
disappearance
ovary
allowing
initiation
new
cycle.
generation
transgenic,
knockout
knockin
mice
development
innovative
technologies
revealed
novel
role
several
molecules
reprogramming
granulosa
into
luteal
hormonal
molecular
control
demise
CL.
current
review
highlights
our
knowledge
these
key
rodents.
Endocrine Reviews,
Год журнала:
2007,
Номер
29(1), С. 1 - 41
Опубликована: Дек. 5, 2007
Prolactin
(PRL)
is
a
23-kDa
protein
hormone
that
binds
to
single-span
membrane
receptor,
member
of
the
cytokine
receptor
superfamily,
and
exerts
its
action
via
several
interacting
signaling
pathways.
PRL
multifunctional
affects
multiple
reproductive
metabolic
functions
also
involved
in
tumorigenicity.
In
addition
being
classical
pituitary
hormone,
humans
produced
by
many
tissues
throughout
body
where
it
acts
as
cytokine.
The
objective
this
review
compare
contrast
aspects
PRL,
from
structure
regulation,
physiology
pathology
rats,
mice,
humans.
At
each
juncture,
questions
are
raised
whether,
or
what
extent,
data
rodents
relevant
homeostasis
Most
current
knowledge
on
has
been
obtained
studies
with
rats
and,
more
recently,
use
transgenic
mice.
Although
information
indispensable
for
understanding
human
health
disease,
there
sufficient
disparity
control
production,
distribution,
physiological
among
these
species
warrant
careful
judicial
extrapolation
Journal of Endocrinology,
Год журнала:
2015,
Номер
226(2), С. T101 - T122
Опубликована: Июнь 22, 2015
The
hypothalamic
control
of
prolactin
secretion
is
different
from
other
anterior
pituitary
hormones,
in
that
it
predominantly
inhibitory,
by
means
dopamine
the
tuberoinfundibular
neurons.
In
addition,
does
not
have
an
endocrine
target
tissue,
and
therefore
lacks
classical
feedback
pathway
to
regulate
its
secretion.
Instead,
regulated
short
loop
feedback,
whereby
itself
acts
brain
stimulate
production
thereby
inhibit
own
Finally,
despite
relatively
simple
name,
has
a
broad
range
functions
body,
addition
defining
role
promoting
lactation.
As
such,
hypothalamo-prolactin
axis
many
characteristics
are
quite
distinct
hypothalamo-pituitary
systems.
This
review
will
provide
brief
overview
our
current
understanding
neuroendocrine
secretion,
particular
focusing
on
plasticity
evident
this
system,
which
keeps
at
low
levels
most
time,
but
enables
extended
periods
hyperprolactinemia
when
necessary
for
Key
beyond
milk
be
discussed,
particularly
inducing
adaptive
responses
multiple
systems
facilitate
lactation,
consequences
if
action
impaired.
A
feature
pleiotropic
activity
may
lactating
state
might
maladaptive
elevated
inappropriately.
Overall,
my
goal
give
flavour
both
history
field
neuroendocrinology,
identify
some
exciting
new
areas
research
development.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(15), С. 5342 - 5342
Опубликована: Июль 28, 2020
The
hair
cycle
and
follicle
structure
are
highly
affected
by
various
hormones.
Androgens—such
as
testosterone
(T);
dihydrotestosterone
(DHT);
their
prohormones,
dehydroepiandrosterone
sulfate
(DHEAS)
androstendione
(A)—are
the
key
factors
in
terminal
growth.
They
act
on
sex-specific
areas
of
body,
converting
small,
straight,
fair
vellus
hairs
into
larger
darker
hairs.
bind
to
intracellular
androgen
receptors
dermal
papilla
cells
follicle.
majority
follicles
also
require
enzyme
5-alpha
reductase
convert
DHT.
Apart
from
androgens,
role
other
hormones
is
currently
being
researched—e.g.,
estradiol
can
significantly
alter
growth
binding
estrogen
influencing
aromatase
activity,
which
responsible
for
(E2).
Progesterone,
at
level
follicle,
decreases
conversion
influence
prolactin
(PRL)
has
been
intensively
investigated,
PRL
were
detected
human
scalp
skin.
Our
review
includes
results
many
analyses
provides
a
comprehensive
up-to-date
understanding
subject
effects
hormonal
changes
Reproductive Biology and Endocrinology,
Год журнала:
2004,
Номер
2(1)
Опубликована: Июль 5, 2004
The
prolactin
(PRL)
and
growth
hormone
(GH)
gene
families
represent
species-specific
expansions
of
pregnancy-associated
hormones/cytokines.
In
this
review
we
examine
the
structure,
expression
patterns,
biological
actions
pregnancy-specific
PRL
GH
families.
