Nature Neuroscience, Год журнала: 2007, Номер 10(8), С. 1003 - 1011
Опубликована: Июль 1, 2007
Язык: Английский
Annual Review of Neuroscience, Год журнала: 2005, Номер 28(1), С. 223 - 250
Опубликована: Март 18, 2005
Forty years since the initial discovery of neurogenesis in postnatal rat hippocampus, investigators have now firmly established that active from neural progenitors continues throughout life discrete regions central nervous systems (CNS) all mammals, including humans. Significant progress has been made over past few understanding developmental process and regulation adult neurogenesis, proliferation, fate specification, neuronal maturation, targeting, synaptic integration newborn neurons. The function this evolutionarily conserved phenomenon, however, remains elusive mammals. Adult represents a striking example structural plasticity mature CNS environment. Advances our will not only shed light on basic principles plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.
Язык: Английский
Процитировано
1811
Nature reviews. Neuroscience, Год журнала: 2006, Номер 7(3), С. 179 - 193
Опубликована: Фев. 22, 2006
Язык: Английский
Процитировано
1333
Annual Review of Neuroscience, Год журнала: 2004, Номер 27(1), С. 549 - 579
Опубликована: Июнь 24, 2004
Neuronal circuits are shaped by experience during critical periods of early postnatal life. The ability to control the timing, duration, and closure these heightened levels brain plasticity has recently become experimentally accessible, especially in developing visual system. This review summarizes our current understanding known across several systems species. It delineates a number emerging principles: functional competition between inputs, role for electrical activity, structural consolidation, regulation (not simply age), special inhibition CNS, potent influence attention motivation, unique timing as well use distinct molecular mechanisms regions potential reactivation adulthood. A deeper will open new avenues "nurture brain"-from international efforts link science education improving recovery from injury devising strategies therapy lifelong learning.
Язык: Английский
Процитировано
1233
Physiological Reviews, Год журнала: 2005, Номер 85(2), С. 523 - 569
Опубликована: Март 23, 2005
The discovery that the adult mammalian brain creates new neurons from pools of stemlike cells was a breakthrough in neuroscience. Interestingly, this particular form structural plasticity seems specific to discrete regions, and most investigations concern subventricular zone (SVZ) dentate gyrus (DG) hippocampal formation (HF). Overall, two main lines research have emerged over last decades: first aims understand fundamental biological properties neural (and their progeny) integration newly born into preexisting networks, while second focuses on understanding its relevance functioning, which has been more extensively approached DG. Here, we propose an overview current knowledge neurogenesis functional for brain. We present analysis methodological issues hampered progress field describe neurogenic sites with specificities. will see despite considerable progress, levels anatomic within host circuitry yet be elucidated. Then intracellular mechanisms controlling neuronal fate are presented briefly, along extrinsic factors regulate neurogenesis. growing list epigenetic display specificity action depending site under consideration identified. Finally, review accomplished implicating functioning physiological conditions development hippocampal-related pathologies such as epilepsy, mood disorders, addiction. This constitutes necessary step promoting therapeutic strategies.
Язык: Английский
Процитировано
967
Cell stem cell, Год журнала: 2008, Номер 3(3), С. 265 - 278
Опубликована: Сен. 1, 2008
Язык: Английский
Процитировано
966
Science, Год журнала: 2014, Номер 344(6184), С. 630 - 634
Опубликована: Май 6, 2014
In the adult central nervous system, vasculature of neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline neurogenesis cognitive function is associated with reduced blood flow decreased numbers cells. Therefore, restoring functionality should counteract some negative effects aging. We show that factors found in young induce vascular remodeling, culminating increased improved olfactory discrimination aging mice. Further, we GDF11 alone can improve cerebral enhance neurogenesis. The identification slow age-dependent deterioration mice may constitute basis for new methods treating age-related neurodegenerative neurovascular diseases.
Язык: Английский
Процитировано
965
European Journal of Neuroscience, Год журнала: 2003, Номер 17(10), С. 2042 - 2046
Опубликована: Май 1, 2003
Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus adult mice. These stimuli are also known improve performance hippocampus-dependent learning tasks, but it is unclear whether their effects on exclusive hippocampal formation. In this study, we housed mice under three conditions (enriched environment, wheel running standard housing), analysed proliferation lateral ventricle wall cell olfactory bulb comparison gyrus. Using bromodeoxyuridine label dividing cells, could not detect any difference number newly generated wall. When giving new time migrate differentiate bulb, observed no changes adult-generated cells; however, enrichment produced a doubling amount cells. The discrepancy between suggests that these living trigger locally through yet unidentified mechanism specific neurogenic signals
Язык: Английский
Процитировано
795
Current Opinion in Genetics & Development, Год журнала: 2003, Номер 13(5), С. 543 - 550
Опубликована: Сен. 12, 2003
Язык: Английский
Процитировано
613
The Annual Review of Pharmacology and Toxicology, Год журнала: 2004, Номер 44(1), С. 399 - 421
Опубликована: Янв. 27, 2004
New cells are continuously generated from immature proliferating throughout adulthood in many organs, thereby contributing to the integrity of tissue under physiological conditions and repair following injury. In contrast, mechanisms adult central nervous system (CNS) have long been thought be very limited. However, recent findings clearly demonstrated that restricted areas mammalian brain, new functional neurons constantly neural stem life. Moreover, with potential give rise reside different regions CNS. These raise possibility endogenous can mobilized replace dying neurodegenerative diseases. Indeed, reports provided evidence that, some injury models, limited neuronal replacement occurs Here, we summarize our current understanding controlling neurogenesis discuss their implications for development strategies treatment
Язык: Английский
Процитировано
594
Journal of Neuroscience, Год журнала: 2004, Номер 24(38), С. 8354 - 8365
Опубликована: Сен. 22, 2004
Previous studies demonstrating olfactory interneuron involvement in discrimination and decreased proliferation the forebrain subventricular zone with age led us to ask whether neurogenesis and, consequently, were impaired aged mice. Pulse labeling showed that mice (24 months of age) had fewer new interneurons bulb than did young adult (2 However, more total their younger counterparts. Aged exhibited no differences from ability discriminate between two discrete odors but significantly poorer at performing discriminations similar (fine discrimination). Leukemia inhibitory factor receptor heterozygote mice, which have less wild-type counterparts, performed poorly fine wild types, suggesting neurogenesis, rather number interneurons, was responsible for discrimination. Immunohistochemistry Western blot analyses revealed a selective reduction expression levels epidermal growth (EGF) (EGFR) signaling elements zone. Waved-1 mutant express reduced quantities transforming factor-α, predominant EGFR ligand adulthood, phenocopy performance on tasks. These results suggest impairment may result EGF-dependent neurogenesis.
Язык: Английский
Процитировано
544