From Cell Interactions to Bedside Practice: Complete Blood Count-Derived Biomarkers with Diagnostic and Prognostic Potential in Venous Thromboembolism
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(1), С. 205 - 205
Опубликована: Янв. 2, 2025
Venous
thromboembolism
(VTE),
encompassing
deep
vein
thrombosis
and
pulmonary
embolism,
is
a
significant
burden
on
health
economic
systems
worldwide.
Improved
VTE
management
calls
for
the
integration
of
biomarkers
into
diagnostic
algorithms
scoring
risk
assessment,
possible
complications,
mortality.
This
literature
review
discusses
novel
with
potential
prognostic
value
in
personalized
management.
The
pathophysiology
starts
cell
interactions
vascular
environment
continues
more
complex,
recently
discussed
processes
such
as
immunothrombosis
thromboinflammation.
Their
clinical
applicability
use
complete
blood
count
(CBC)-derived
immuno-inflammatory
indices
attractive,
readily
available
that
reflect
pro-thrombotic
states.
Indices
neutrophil-to-lymphocyte
ratio
(NLR
=
neutrophil
divided
by
lymphocyte
count),
platelet-to-lymphocyte
(PLR
platelet
systemic
immune-inflammation
index
(SII
NLR
multiplied
count)
have
demonstrated
predictive
thromboembolic
events.
Nevertheless,
confounding
data
regarding
cutoffs
may
be
implemented
practice
limit
their
applicability.
aims
to
investigate
key
drivers
thromboinflammation
while
summarizing
relevant
research
corresponding
CBC-derived
biomarkers,
well
utility
day-to-day
practice.
Язык: Английский
Temporal Dichotomy of Neutrophil Function in Acute Liver Injury and Repair
JHEP Reports,
Год журнала:
2025,
Номер
unknown, С. 101417 - 101417
Опубликована: Апрель 1, 2025
Язык: Английский
Spatiotemporal regulation of neutrophil heterogeneity in health and disease
Human Molecular Genetics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Neutrophils
are
the
most
abundant
leukocytes
in
humans
and
indispensable
for
innate
immunity.
They
short-lived,
terminally
differentiated
cells.
However,
mounting
evidence
indicates
that
neutrophils
heterogeneous
health
disease:
they
young
or
aged
a
steady
state,
while
their
heterogeneity
becomes
more
diverse
disease
conditions,
such
as
cancer,
sepsis,
thromboinflammation.
Although
presence
of
distinct
neutrophil
subsets
is
well
recognized,
it
not
fully
understood
how
have
functional
phenotypic
what
mechanisms
control
it.
This
review
will
focus
on
our
current
understanding
molecular
basis
pathophysiological
conditions.
In
addition,
we
discuss
possibility
targeting
specific
subset
to
attenuate
inflammation
tissue
damage
without
compromising
immune
responses.
Язык: Английский
Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis
Gastrointestinal Disorders,
Год журнала:
2024,
Номер
6(3), С. 557 - 606
Опубликована: Июнь 22, 2024
The
growing
field
of
gut–brain
axis
research
offers
significant
potential
to
revolutionize
medical
practices
and
improve
human
well-being.
Neutrophils
have
emerged
as
key
players
in
inflammation,
contributing
the
relocation
inflammatory
cells
from
gut
brain
exacerbating
neuroinflammation
conditions,
such
bowel
disease
neurodegenerative
diseases.
intricate
network
molecular
functional
connections
that
interlinks
with
gastrointestinal
system
is
characterized
by
complex
signaling
pathways.
Understanding
interplay
among
microbiota,
gut,
unparalleled
opportunities
develop
novel
therapeutic
interventions
for
neurological
disorders
overall
health
outcomes.
aim
this
review
was
comprehensively
summarize
current
knowledge
future
perspectives
regarding
multifaceted
role
neutrophils
their
impact
on
neuroimmune
dynamics
context
axis.
Язык: Английский
Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice
Cells,
Год журнала:
2024,
Номер
13(18), С. 1568 - 1568
Опубликована: Сен. 18, 2024
Cardiotonic
steroids
are
known
to
bind
Na+/K+-ATPase
and
regulate
several
biological
processes,
including
the
immune
response.
The
synthetic
cardiotonic
steroid
γ-Benzylidene
Digoxin
8
(BD-8)
is
emerging
as
a
promising
immunomodulatory
molecule,
although
it
has
remained
largely
unexplored.
Therefore,
we
tested
potential
of
BD-8
both
in
vitro
vivo.
Hence,
primary
mouse
macrophages
were
incubated
with
combinations
pro-inflammatory
fungal
protein
zymosan
(ZYM).
Nitric
oxide
(NO)
production
was
determined
by
Griess
reagent
cytokines
assessed
enzyme-linked
immunosorbent
assay.
Inducible
nitric
synthase
(iNOS),
reactive
oxygen
species
(ROS),
p-nuclear
factor
kappa
B
p65
(NF-κB
p65),
p-extracellular
signal-regulated
kinase
(p-ERK),
p-p38
evaluated
flow
cytometry.
Macrophages
exposed
displayed
reduced
phagocytic
activity,
NO
levels,
proinflammatory
cytokine
IL-1β
induced
ZYM.
Furthermore,
diminished
expression
iNOS
phosphorylation
NF-κB
p65,
ERK,
p38.
Additionally,
exhibited
anti-inflammatory
capacity
vivo
carrageenan-induced
paw
edema
model.
Taken
together,
these
findings
demonstrate
activity
further
reinforce
their
derivatives
molecules.
Язык: Английский
Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry
Histochemistry and Cell Biology,
Год журнала:
2024,
Номер
162(4), С. 273 - 286
Опубликована: Июнь 24, 2024
Neutrophil
extracellular
traps
(NETs)
and
placental
neutrophil
reverse
transmigration
(r-TM)
are
implicated
in
the
pathogenesis
of
pre-eclampsia
(PE).
However,
role
comorbidity
PE
human
immunodeficiency
virus
(HIV)
infection
r-TM
serum
NETs
remains
unknown.
Human
tissue
(n
=
160)
80)
samples
were
obtained
post-ethical
approval
divided
by
pregnancy
type
HIV
status
across
study
population.
Immunohistochemistry
morphometry
performed
to
localize
quantify
junctional
adhesion
molecule-C
(JAM-C)
expression
as
an
inverse
marker
within
villi.
An
enzyme-linked
immunosorbent
assay
(ELISA)
was
concentration
citrullinated
histone
H3
(cit-H3)
a
NETs.
GraphPad
Prism
(version
8.0.2)
used
compare
results,
p
value
<
0.05
considered
statistically
significant.
The
localization
JAM-C
observed
on
syncytiotrophoblasts
(STBs)
endothelial
cells
immunoexpression
elevated
vs.
normotensive
(N)
placentae.
In
exchange
villi,
higher
N+ve
N-ve
group.
comorbid
infection,
lower
PE+ve
PE-ve
Citrullinated
histone-H3
group
but
early-onset
(EOPE)+ve
late-onset
(LOPE)+ve
These
results
indicate
that
HIV-infected
placentae
individually
express
JAM-C,
manifesting
less
r-TM.
villi
with
reduced
enhances
r-TM,
thus
supporting
synergistic
effect
HIV.
Язык: Английский
Developing Cell-Membrane-Associated Liposomes for Liver Diseases
Dongxue Ge,
Ran An,
Lingling Xue
и другие.
ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29421 - 29438
Опубликована: Окт. 15, 2024
Over
the
past
decade,
a
marked
escalation
in
prevalence
of
hepatic
pathologies
has
been
observed,
adversely
impacting
quality
life
for
many.
The
predominant
therapeutic
strategy
liver
diseases
pharmacological
intervention;
however,
its
efficacy
is
often
constrained.
Currently,
liposomes
are
tiny
structures
that
can
deliver
drugs
directly
to
targeted
areas,
enhancing
their
effectiveness.
Specifically,
cell
membrane-associated
have
gained
significant
attention.
Despite
this,
there
still
much
learn
about
binding
mechanism
this
type
liposome.
Thus,
review
comprehensively
summarizes
relevant
information
on
liposomes,
including
clinical
applications
and
future
development
directions.
First,
we
will
briefly
introduce
composition
types
liposomes.
We
provide
an
overview
structure
discuss
various
associated
with
membranes.
Second,
thoroughly
strategies
drug
delivery
using
these
Lastly,
application
challenges
treating
diseases.
explore
potential
benefits
while
also
addressing
obstacles
need
be
overcome.
Furthermore,
prospects
field.
In
summary,
underscores
promise
disease
treatment
highlights
further
research
optimize
utilization.
Язык: Английский