Interleukin-6 secretion upon acute psychosocial stress as a potential predictor of psychotherapy outcome in posttraumatic stress disorder DOI
Cosima Rhein, Tobias Hepp,

Olga Kraus

et al.

Journal of Neural Transmission, Journal Year: 2021, Volume and Issue: 128(9), P. 1301 - 1310

Published: May 14, 2021

Language: Английский

To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers DOI Open Access
Ghazi I. Al Jowf, Ziyad T. Ahmed, Rick A. Reijnders

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5238 - 5238

Published: March 9, 2023

Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in reduced quality of life increased economic burden. The is directly related to exposure traumatic event, e.g., real or threatened injury, death, sexual assault. Extensive research has been done on the neurobiological alterations underlying its phenotypes, revealing brain circuit disruption, neurotransmitter dysregulation, hypothalamic–pituitary–adrenal (HPA) axis dysfunction. Psychotherapy remains first-line treatment option for PTSD given good efficacy, although pharmacotherapy also be used as stand-alone combination with psychotherapy. In order reduce prevalence burden disorder, multilevel models prevention have developed detect early possible morbidity those established diseases. Despite clinical grounds diagnosis, attention increasing discovery reliable biomarkers that predict susceptibility, aid monitor treatment. Several potential linked pathophysiological changes PTSD, encouraging further identify actionable targets. This review highlights current literature regarding pathophysiology, disease development models, modalities, preventive from public health perspective, discusses state biomarker research.

Language: Английский

Citations

51
Title: “Labels Matter: Is it stress or is it Trauma?” DOI Creative Commons
Gal Richter‐Levin, Carmen Sandi

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 10, 2021

Abstract In neuroscience, the term ‘Stress’ has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in face exposure stress, more common reaction stress is resilience, indicating that resilience rule and stress-related pathology exception. This critical neural mechanisms associated with psychopathology are expected differ significantly from those resilience. Research labels terminology affect research directions, conclusions drawn results, way we think about topic, while choice often influenced by biases hidden assumptions. It therefore important adopt differentiates between conditions, leading different outcomes. Here, propose conceptually associate ‘stress’/‘stressful experience’ ‘stress resilience’, restricting use ‘trauma’ only reference exposures lead pathology. We acknowledge there as yet no ideal ways for addressing murkiness border stressful traumatic experiences. ignoring these differences hampers our ability elucidate trauma-related pathologies on one hand, other. Accordingly, discuss how translate such conceptual into practice.

Language: Английский

Citations

56
Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression DOI Creative Commons
Carina Seah, Michael S. Breen,

Tom Rusielewicz

et al.

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(11), P. 1434 - 1445

Published: Oct. 20, 2022

Abstract Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute individual clinical outcomes is unknown. Here, we compared transcriptional responses hydrocortisone exposure in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons peripheral blood mononuclear cells (PBMCs) from combat veterans with PTSD ( n = 19 hiPSC 20 PBMC donors) controls donors). In only, observed diagnosis-specific glucocorticoid-induced changes gene expression corresponding PTSD-specific transcriptomic patterns found postmortem brains. We glucocorticoid hypersensitivity neurons, identified genes that this PTSD-dependent response. find evidence of a coregulated network transcription mediates hyper-responsivity PTSD. These findings suggest represent platform for examining molecular mechanisms underlying PTSD, identifying biomarkers response, conducting drug screening identify new therapeutics.

Language: Английский

Citations

41
Innate and adaptive immune system consequences of post-traumatic stress disorder DOI

Tatlock H. Lauten,

Tamara Natour, Adam J. Case

et al.

Autonomic Neuroscience, Journal Year: 2024, Volume and Issue: 252, P. 103159 - 103159

Published: Feb. 23, 2024

Language: Английский

Citations

8
On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents DOI
Lucas Gazarini, Cristina Aparecida Jark Stern, Leandro J. Bertoglio

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 147, P. 105101 - 105101

Published: Feb. 17, 2023

Language: Английский

Citations

18
Post Traumatic Stress Disorder associated Hypothalamic-Pituitary-Adrenal Axis Dysregulation and Physical Illness DOI Creative Commons

Stephanie Lawrence,

R. Hal Scofield

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 41, P. 100849 - 100849

Published: Aug. 23, 2024

Language: Английский

Citations

7
Blunted salivary cortisol response to psychosocial stress in women with posttraumatic stress disorder DOI
Sophie Metz,

Moritz Duesenberg,

Julian Hellmann‐Regen

et al.

Journal of Psychiatric Research, Journal Year: 2020, Volume and Issue: 130, P. 112 - 119

Published: Aug. 2, 2020

Language: Английский

Citations

42
PTSD, Immune System, and Inflammation DOI
Nela Pivac,

Barbara Vuić,

Marina Šagud

et al.

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 225 - 262

Published: Jan. 1, 2023

Language: Английский

Citations

14
Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD DOI Creative Commons

Zachary Blalock,

Gwyneth W. Y. Wu, Daniel Lindqvist

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 10, 2024

Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or stress and potential novel psychological various brain, somatic, psychiatric disorders. No studies have yet analyzed ccf-mtDNA levels in post-traumatic disorder (PTSD), despite evidence dysfunction this condition. In the current study, we compared plasma combat trauma-exposed male veterans with PTSD (n = 111) those who did not develop 121) also investigated relationship between ccf mt-DNA glucocorticoid sensitivity. unadjusted analyses, differ significantly non-PTSD groups (t 1.312, p 0.191, Cohen's d 0.172). sensitivity analysis excluding participants diabetes using antidepressant medication controlling for age, group had lower than (F(1, 179) 5.971, 0.016, partial η

Language: Английский

Citations

5
Validity of mental and physical stress models DOI Creative Commons

Erin Hendry,

Brady McCallister,

Dan J. Elman

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105566 - 105566

Published: Feb. 2, 2024

Language: Английский

Citations

5