Antioxidants, Год журнала: 2025, Номер 14(3), С. 256 - 256
Опубликована: Фев. 23, 2025
Endothelial dysfunction (ED) is characterized by an imbalance between vasodilatory and vasoconstrictive factors, leading to impaired vascular tone, thrombosis, inflammation. These processes are critical in the development of cardiovascular diseases (CVDs) such as atherosclerosis, hypertension ischemia/reperfusion injury (IRI). Reduced nitric oxide (NO) production increased oxidative stress key contributors ED. Aging further exacerbates ED through mitochondrial oxidative/nitrosative stress, heightening CVD risk. Antioxidant systems like superoxide-dismutase (SOD), glutathione-peroxidase (GPx), thioredoxin/thioredoxin-reductase (Trx/TXNRD) pathways protect against stress. However, their reduced activity promotes ED, vulnerability IRI. Metabolic syndrome, comprising insulin resistance, obesity, hypertension, often accompanied Specifically, hyperglycemia worsens endothelial damage promoting Obesity leads chronic inflammation changes perivascular adipose tissue, while associated with increase The NLRP3 inflammasome plays a significant role being triggered factors reactive oxygen nitrogen species, ischemia, high glucose, which contribute inflammation, injury, exacerbation Treatments, N-acetyl-L-cysteine, SGLT2 or inhibitors, show promise improving function. Yet complexity suggests that multi-targeted therapies addressing metabolic disturbances essential for managing CVDs syndrome.
Язык: Английский
Процитировано
2Endothelial cytoskeleton in mechanotransduction and vascular diseases
Journal of Biomechanics, Год журнала: 2025, Номер 182, С. 112579 - 112579
Опубликована: Фев. 9, 2025
Язык: Английский
Процитировано
1Unlocking New Frontiers in Cell Signaling and Communication and Fostering New Collaborative Interactions and Scientific Initiatives: Lessons Learned from the International Cellular Communication Network Society (ICCNS) Workshop
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0LIM kinases in cardiovascular health and disease
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Дек. 18, 2024
The Lim Kinase (LIMK) family of serine/threonine kinases is comprised LIMK1 and LIMK2, which are central regulators cytoskeletal dynamics via their well-characterized roles in promoting actin polymerization destabilizing the cellular microtubular network. LIMKs have been demonstrated to modulate several fundamental physiological processes, including cell cycle progression, motility migration, differentiation. These processes play important maintaining cardiovascular health. However, LIMK activity healthy pathological states system poorly characterized. This review highlights molecular mechanisms involved activation inactivation, examining its pathophysiology vascular cardiac diseases such as hypertension, aneurysm, atrial fibrillation, valvular heart disease. It addresses LIMKs' involvement that support health, vasculogenesis, angiogenesis, endothelial mechanotransduction. also features how participates cell, smooth muscle cardiomyocyte physiology implications states. A few recent preclinical studies demonstrate therapeutic potential inhibition. We conclude by proposing future research should focus on clinical relevance inhibitors agents reduce burden disease improve patient outcomes.
Язык: Английский
Процитировано
1REPLY
Ophthalmology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Процитировано
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