Lower Respiratory Microbiome Dysbiosis is Associated with Poor Prognosis in Acute Severe Lower Respiratory Tract Infection

Опубликована: Янв. 1, 2025

Язык: Английский

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Gastrointestinal (GI)-Lung-Brain Axis

Seminars in Fetal and Neonatal Medicine, Год журнала: 2025, Номер unknown, С. 101639 - 101639

Опубликована: Апрель 1, 2025

Язык: Английский

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Engineering inhalable nanomedicines to navigate lung barriers for effective pulmonary fibrosis therapy

Nano Today, Год журнала: 2025, Номер 64, С. 102778 - 102778

Опубликована: Май 2, 2025

Язык: Английский

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Xuanfei Baidu Decoction ameliorates bleomycin-elicited idiopathic pulmonary fibrosis in mice by regulating the lung-gut crosstalk via IFNγ/STAT1/STAT3 axis

Phytomedicine, Год журнала: 2024, Номер 135, С. 155997 - 155997

Опубликована: Сен. 2, 2024

Язык: Английский

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State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea

Journal of Investigative Medicine, Год журнала: 2024, Номер 72(7), С. 589 - 619

Опубликована: Май 8, 2024

In the general population, Bronchial Asthma (BA) and Obstructive Sleep Apnea (OSA) are among most prevalent chronic respiratory disorders. Significant epidemiologic connections complex pathogenetic pathways link these disorders via interactions at genetic, epigenetic, environmental levels. The coexistence of BA OSA in an individual likely represents a distinct syndrome, that is, collection clinical manifestations attributable to several mechanisms pathobiological signatures. To avoid terminological confusion, this association has been named alternative overlap syndrome (vs represented by obstructive pulmonary disease-OSA association). This comprehensive review summarizes complex, often bidirectional links between constituents syndrome. Cross-sectional, or clinic-based studies unlikely elucidate causality directionality relationships. Even longitudinal epidemiological evaluations cohorts developing over time OSA, during follow-up cannot exclude factors causal influence other known unknown mediators. As such, lot pathophysiological described here have suggestive evidence, biological plausibility, potential actual directionality. By showcasing existing evidence current knowledge gaps, hope is deliberate, focused, collaborative efforts near-future will be geared toward opportunities shine light on unknowns accelerate discovery field health, care, education, research, scholarly endeavors.

Язык: Английский

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Gut microbes coordinate pulmonary immunity

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(25)

Опубликована: Июнь 6, 2024

Язык: Английский

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Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma

Frontiers in Allergy, Год журнала: 2024, Номер 5

Опубликована: Авг. 2, 2024

Asthma is a chronic respiratory disease of global importance. Mouse models allergic asthma have been instrumental in advancing research and novel therapeutic strategies for patients. The application relevant allergens physiological routes exposure such has led to valuable insights into the complexities onset development as well key mechanisms. Furthermore, environmental microbial exposures infections shown play fundamental part pathogenesis alter outcome. In this review, we delve mouse explore literature reports on most significant interplays between with relevance human disease.

Язык: Английский

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Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis

npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 12, 2024

Язык: Английский

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Causal roles of skin and gut microbiota in skin appendage disorders suggested by genetic study

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 10, 2024

There is evidence from observational studies that human microbiota linked to skin appendage Disorders (SADs). Nevertheless, the causal association between and SADs yet be fully clarified.

Язык: Английский

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Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 25, 2024

The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate role of in COPD through network pharmacology Mendelian randomization approaches.

Язык: Английский

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