The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Янв. 6, 2024

Abstract Background In the American population, relationship between triglyceride-glucose (TyG) index and TYG combined with indicators of obesity cardiovascular disease (CVD) its mortality has been less well studied. Methods This cross-sectional study included 11,937 adults from National Health Nutrition Examination Survey (NHANES) 2003–2018. Cox proportional hazards model, binary logistic regression analyses, restricted cubic spline (RCS), receiver operating characteristic (ROC) were used to analyze TyG obesity-related CVD mortality. Mediation analysis explored mediating role glycated hemoglobin insulin in above relationships. Results this study, except for no significant association mortality, TyG, TyG-WC, TyG-WHtR, TyG-BMI significantly positively associated TyG-WHtR is strongest predictor (HR 1.66, 95% CI 1.21–2.29). The correlated better risk coronary heart (OR 2.52, 1.66–3.83). TyG-WC best total 2.37, 1.77–3.17), congestive failure 2.14, 1.31–3.51), angina pectoris 2.38, 1.43–3.97). myocardial infarction 2.24, 1.45–3.44). RCS analyses showed that most relationships linear (P-overall < 0.0001, P-nonlinear > 0.05). Otherwise, ROC curves had more robust diagnostic efficacy than TyG. mediation mediated all insulin-mediated partial Conclusions TyG-WtHR enhance prediction, correlation some over current hottest are expected become effective metrics identifying populations at early improve stratification.

Язык: Английский

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FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

Metabolism, Год журнала: 2021, Номер 122, С. 154840 - 154840

Опубликована: Июль 29, 2021

Язык: Английский

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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Март 1, 2024

Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac diseases cardiovascular neurological disorders, kidney motor system metabolic disorders. Examining the upstream modulators co-activated partners identifying critical biological events modulated by downstream effectors contribute to presentation elaborate network PGC-1s. Furthermore, discussing correlation between well summarizing therapy targeting helps make individualized precise intervention methods. In this review, we summarize basic knowledge regarding molecular regulatory network, discuss physio-pathological roles human review application PGC-1s, diagnostic prognostic value several therapies pre-clinical studies, suggest directions for future investigations. This presents immense potential treatment hopefully facilitates promotion new therapeutic targets.

Язык: Английский

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Obesity-related kidney disease: Beyond hypertension and insulin-resistance

Frontiers in Endocrinology, Год журнала: 2023, Номер 13

Опубликована: Янв. 16, 2023

Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting myriad cytokines adipokines that contribute to insulin resistance induce chronic low-grade inflammatory state thereby damaging kidney. development itself associated with various metabolic alterations exacerbate adipose tissue dysfunction resistance. This adipose-renal axis major focus current research, given rising incidence obesity. Cellular senescence biologic hallmark aging, age another obesity CKD. An elevated senescent cell burden predicts renal animal models, senotherapies may alleviate these phenotypes. In this review, we discuss direct mechanisms which contributes emphasizing potential clinical importance such pathways augmenting care

Язык: Английский

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Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 1211 - 1211

Опубликована: Янв. 19, 2024

This comprehensive review explores the critical role of fatty acid (FA) metabolism in cardiac diseases, particularly heart failure (HF), and implications for therapeutic strategies. The heart’s reliance on ATP, primarily sourced from mitochondrial oxidative metabolism, underscores significance metabolic flexibility, with oxidation (FAO) being a dominant source. In HF, shifts occur an altered FA uptake FAO, impacting function contributing to disease progression. Conditions like obesity diabetes also lead disturbances, resulting cardiomyopathy marked by over-reliance dysfunction, lipotoxicity. Therapeutic approaches targeting diseases have evolved, focusing inhibiting or stimulating FAO optimize energetics. Strategies include using CPT1A inhibitors, PPARα agonists, enhancing biogenesis function. However, effectiveness varies, reflecting complexity remodeling HF. Hence, treatment strategies should be individualized, considering that energy is intricate tightly regulated. aim overall function, recognizing pivotal FAs need further research develop effective therapies, promising new improve

Язык: Английский

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Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 12, 2025

Physical exercise is a cornerstone for preventing diet-induced obesity, while it unclear whether physical could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to exercise. As expected, prevented HFCD-induced whole-body fat deposition. However, exacerbated damage. Further metabolomic analysis results showed that induced circulating lipid redistribution, leading excessive uptake lipotoxicity. Our study provides valuable insights into the effects of in HFCD, suggesting counteracting negative effect by simultaneous might be detrimental. Moreover, inappropriate may damage certain organs even though leads weight loss overall metabolic benefits. Of note, current findings are based on animal experiments, generalizability these beyond this specific mouse strain remains further explored. While benefits well known, less clear can prevent obesity. authors show gain mice, surprisingly worsened heart due

Язык: Английский

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ER stress and inflammation crosstalk in obesity

Medicinal Research Reviews, Год журнала: 2022, Номер 43(1), С. 5 - 30

Опубликована: Авг. 17, 2022

Abstract The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins through various chaperones enzymes residing within ER organelle. Perturbation in process ensues when overwhelmed protein exceeds handling capacity, leading to accumulation misfolded/unfolded lumen—a state being referred as stress. In turn, stress induces a gamut signaling cascades, termed “unfolded response” (UPR) that reinstates homeostasis panel gene expression modulation. This type UPR is usually deemed “adaptive UPR.” However, persistent or unresolved hyperactivates response, which ultimately, triggers cell death inflammatory pathways, “maladaptive/terminal A plethora evidence indicates crosstalks between (maladaptive UPR) inflammation precipitate obesity pathogenesis. this regard, acquisition mechanisms linking might unveil potential remedies tackle pathological condition. Herein, we aim elucidate key stress‐induced context summarize therapeutic strategies management maneuvering stress‐associated inflammation.

Язык: Английский

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CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis

Pharmacological Research, Год журнала: 2022, Номер 176, С. 106086 - 106086

Опубликована: Янв. 13, 2022

Язык: Английский

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Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart

Nutrients, Год журнала: 2022, Номер 14(2), С. 251 - 251

Опубликована: Янв. 7, 2022

Intermittent fasting (IF) plays an essential role in improving lipid metabolism disorders caused by metabolic cardiomyopathy. Growing evidence revealed that N6-methyladenosine (m6A) RNA methylation is related to obesity and metabolic. Our study aimed assess the beneficial effects of IF on deposition, apoptosis, m6A high-fat diet (HFD)-induced Male C57BL/6J mice were fed a normal (ND) or HFD ad libitum for 13 weeks, after which time subgroup subjected 24 h other day 8 weeks. We found intervention significantly improved cardiac functional structural impairment serum disorder induced HFD. Furthermore, decreased mRNA levels fatty acid uptake genes FABP1, FATP1, CD36 synthesis SREBF1, FAS, ACCα increased catabolism ATGL, HSL, LAL, LPL tissueof HFD-induced obese mice. TUNEL-positive cells, Bax/Bcl-2 ratio, Cleaved Caspase-3 protein expression hearts was down-regulated intervention. In addition, METTL3 FTO conclusion, our findings demonstrate attenuated deposition as well cardiomyopathy, mechanism associated with levels.

Язык: Английский

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Emerging Roles and Mechanism of m6A Methylation in Cardiometabolic Diseases

Cells, Год журнала: 2022, Номер 11(7), С. 1101 - 1101

Опубликована: Март 24, 2022

Cardiometabolic diseases (CMDs) are currently the leading cause of death and disability worldwide, their underlying regulatory mechanisms remain largely unknown. N6-methyladenosine (m6A) methylation, most common abundant epigenetic modification eukaryotic mRNA, is regulated by m6A methyltransferase, demethylase, binding protein, which affect transcription, cleavage, translation, degradation target mRNA. methylation plays a vital role in physiological pathological processes CMDs. In this review, we summarize played CMDs, including obesity, hypertension, pulmonary ischemic heart disease, myocardial hypertrophy, failure, atherosclerosis. We also describe that potentially involve participation such as those driving calcium homeostasis, circadian rhythm, lipid metabolism, autophagy, macrophage response, inflammation. its regulators expected to be targets for treatment

Язык: Английский

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