Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 24, 2024

Abstract Background Triglyceride-glucose (TyG) index has been determined to play a role in the onset of metabolic syndrome (MetS). Whether TyG and with combination obesity indicators are associated clinical outcomes MetS population remains unknown. Method Participants were extracted from multiple cycles National Health Nutrition Examination Survey (NHANES) between 1999 2018 years. Three constructed including index, combining waist circumference (TyG-WC), waist-to-height ratio (TyG-WHtR). The was defined according Cholesterol Education Program (NCPE) Adult Treatment Panel III. Kaplan-Meier (KM) curves, restricted cubic splines (RCS), Cox proportional hazard model used evaluate associations TyG-related indices mortality population. sensitive analyses performed check robustness main findings. Results There 10,734 participants included this study, 5,570 females 5,164 males. median age study 59 years old. multivariate regression showed high levels significantly all-cause [TyG index: adjusted (aHR): 1.36, 95%confidence interval (CI): 1.18–1.56, p < 0.001; TyG-WHtR aHR = 1.29, 95%CI: 1.13–1.47, 0.001]. Meanwhile, TyG-WC cardiovascular (TyG-WC: 1.45, 1.13–1.85, 0.004; TyG-WHtR: 1.50 1.17–1.92, 0.002). consistent significant correlations diabetes (TyG: 4.06, 2.81–5.87, TyG-WC: 2.55, 1.82–3.58, 2.53 1.81–3.54, 0.001). RCS curves non-linear trend (p for nonlinearity 0.004 0.001, respectively). supported positive Conclusion Our highlights value predicting survival would be surrogate biomarkers follow-up

Язык: Английский

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Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin

Hypertension, Год журнала: 2024, Номер 81(7), С. 1637 - 1643

Опубликована: Май 16, 2024

Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.

Язык: Английский

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Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Май 29, 2024

Abstract Background Triglyceride and glucose (TyG) index, a surrogate marker of insulin resistance, has been validated as predictor cardiovascular disease. However, effects TyG-related indices combined with obesity markers on diseases remained unknown. We aimed to investigate the associations between TyG index modified new-onset disease time-dependent predictive capacity using national representative cohort. Methods This study is retrospective observational cohort data from China Health Retirement Longitudinal Study (CHARLS) 7 115 participants. The was calculated Ln [fasting triglyceride (mg/dL) × fasting (mg/dL)/2]. were developed combining body mass (BMI), waist circumference (WC) waist-to‐height ratio (WHtR). used adjusted Cox proportional hazards regression analyze association based hazard (HR) Harrell’s C‐index. Results Over 7-year follow‐up period, 2136 participants disease, including 1633 cases coronary heart 719 stroke. Compared lowest tertile group, HR (95% CI) for in highest TyG, TyG-BMI, TyG-WC, TyG-WHtR 1.215 (1.088–1.356), 1.073 (0.967–1.191), 1.078 (0.970–1.198), 1.112 (1.002–1.235), respectively. C‐indices onset higher than other indices. Similar results observed Conclusion TyG-WhtR significantly associated diseases, outperformed identify individuals at risk incident event.

Язык: Английский

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Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 19, 2024

Abstract Background Triglyceride glucose (TyG) index and its related parameters have been introduced as cost-effective surrogate indicators of insulin resistance, while prospective evidence their effects on atherosclerotic cardiovascular disease (ASCVD) remained scattered inconsistent. We aimed to evaluate the association TyG with new-onset ASCVD, predictive capacity were further compared. Method A total 95,342 ASCVD-free participants enrolled from Kailuan study. defined by fasting blood glucose, triglyceride, body mass (BMI), waist circumstance (WC) waist-to-height ratio (WHtR). The primary outcome was incident comprising myocardial infarction (MI) ischemic stroke (IS). Cox proportional hazard models restricted cubic spline (RCS) analyses adopted investigate between each ASCVD. C-index, integrated discrimination improvement (IDI), net reclassification (NRI) used for comparison value Results During a median follow-up 15.0 years, 8,031 new cases ASCVD identified. incidence rate increased along elevated levels index, relationships found be nonlinear in RCS analyses. (HR) 95% confidence interval (95% CI) 1.39 (1.35, 1.43), 1.46 (1.41, 1.50), 1.50 (1.46, 1.55), 1.52 (1.48, 1.57) per 1 IQR increase baseline TyG, TyG-BMI, TyG-WC, TyG-WHtR, respectively, more pronounced females younger individuals aged < 60 years ( P interaction <0.05). Using updated mean or time-varying measurements instead did not significantly alter findings. Additionally, TyG-WC TyG-WHtR showed better performance predicting risk than IDI 0.004 (0.001, 0.004) category-free NRI 0.120 (0.025, 0.138) 0.143 (0.032, 0.166), respectively. Similar findings observed MI IS. Conclusions Both positively associated had which might suitable indices stratification enhance prevention

Язык: Английский

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Association between triglyceride glucose-waist height ratio index and cardiovascular disease in middle-aged and older Chinese individuals: a nationwide cohort study

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 11, 2024

Abstract Background The triglyceride-glucose (TyG) index and its combination with obesity indicators can predict cardiovascular diseases (CVD). However, there is limited research on the relationship between changes in triglyceride glucose-waist height ratio (TyG-WHtR) CVD. Our study aims to investigate change TyG-WHtR risk of Methods Participants were from China Health Retirement Longitudinal Study (CHARLS). CVD was defined as self-reporting heart disease stroke. divided into three groups based using K-means cluster analysis. Multivariable binary logistic regression analysis used examine association different (based TyG-WHtR) A restricted cubic spline (RCS) model explore potential nonlinear cumulative events. Results During follow-up 2015 2020, 623 (18.8%) 3312 participants developed After adjusting for various confounders, compared consistently low stable TyG-WHtR, significantly higher moderate increasing (OR 1.28, 95%CI 1.01–1.63) high a slowly trend 1.58, 1.16–2.15). Higher levels independently associated events (per SD, OR 1.27, 1.12–1.43). Conclusions For middle-aged older adults, are Maintaining favorable TyG index, effective weight management, reasonable waist circumference contribute preventing

Язык: Английский

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Association of triglyceride glucose-related parameters with all-cause mortality and cardiovascular disease in NAFLD patients: NHANES 1999–2018

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 18, 2024

Abstract Background The relationship between the triglyceride-glucose (TyG) index and its derived index, triglyceride glucose-waist height ratio (TyG-WHtR), with mortality cardiovascular diseases (CVDs) in patients non-alcoholic fatty liver disease (NAFLD) remains unclear. Methods This study enrolled 6627 adults aged 18 above diagnosed NAFLD from National Health Nutrition Examination Survey (NHANES, 1999–2018). Binary weighted logistic regression analyses, cox proportional hazards model restricted cubic spline (RCS) were used to analyze TyG TyG-WHtR all-cause mortality, CVD CVDs. Mediation analysis explored mediating role of glycohemoglobin, insulin hypertension relationships. Meanwhile, incremental predictive value was further assessed. Results Except for no significant association both chronic heart failure (CHF), exhibited positive correlations or trends correlation total-CVD, CHF, coronary (CHD) angina pectoris. For a better predictor than (TyG-WHtR: HR 1.31, 95%CI 1.03–1.66; 2.22, 1.42–3.47; OR 3.99, 1.79–8.93). In contrast, demonstrated stronger CHD pectoris (TyG index: 2.00, 1.26–3.18; 1.85, 1.19–2.91; 2.93, 1.23-7.00). RCS showed that after adjusting covariates, most aforementioned relationships linear(P overall < 0.0001, P-nonlinear > 0.05), while associations CHF non-linear(P P nonlinear 0.05). addition basic outcomes improved C-statistics, net reclassification improvement value, integrated discrimination value. Conclusions risk significant. might be valid predictors NAFLD.

Язык: Английский

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Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июнь 1, 2024

Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management

Язык: Английский

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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 8, 2025

Among hypertensive cohorts across different nations, the relationship between triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence mortality remains be elucidated. This study enrolled 9,283, 164,357, 5,334 hypertensives from National Health Nutrition Examination Survey (NHANES), UK Biobank (UKBB), Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models Mendelian randomization analysis. Mediation analysis explored mediating role of inflammatory markers above relationships. Five measures insulin resistance linked death a U-shaped pattern, highest group having risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was higher all-cause (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: 1.17, 1.00–1.36), 1.36, 1.23–1.49, 1.32, 1.00–1.72) risks. In China cohort, triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) associated risks stroke (HR 1.31, 1.00–1.73 1.67, 1.06–2.63). Inflammation like systemic response (SIRI) C-reactive protein (CRP) partially explained these links, CRP stronger effect. Genetically predicted TyG also (OR 1.26, 1.10–1.45) risk. An elevated indices are significantly correlated an increased three national cohorts. These anticipated serve as valid predictors incident individuals hypertension.

Язык: Английский

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Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

Insulin resistance proxy indicators are significantly associated with cardiovascular disease (CVD) and diabetes. However, the correlations between estimated glucose disposal rate (eGDR) index CVD its subtypes have yet to be thoroughly researched. 10,690 respondents diabetes prediabetes from NHANES 1999-2016 were enrolled in study. Three machine learning methods (SVM-RFE, XGBoost, Boruta algorithms) employed select most critical variables. Logistic regression models established evaluate association eGDR CVD. We applied ROC curves, C-statistics, NRI, IDI, calibration DCA curves assess model performance. Subgroup analyses conducted investigate among different subgroups. Participants higher quartile showed a decreased prevalence of Multivariate logistic RCS demonstrated that had an independently negative linear correlation likelihood CVD[Q4 vs. Q1: OR 0.24(0.18,0.32)], CAD[OR 0.81(0.78,0.85)], CHF[OR 0.81(0.76,0.86)], stroke[0.85(0.80,0.90)]. Model evaluation better performance fully adjusted than basic models[C-statistics(Model 3 1): CVD(0.683 0.814), CAD(0.672 0.807), CHF(0.714 0.839) stroke(0.660 0.790)]. The AUCs values other IR surrogates unadjusted models, slightly models. indicated results robust. A lower was heightened diabetic prediabetic populations. And exhibited evaluating associations compared proxies encompassing TyG, HOMA-IR, QCUIKI, METS-IR, etc.

Язык: Английский

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Association between Heavy metals and triglyceride-glucose-related index: a mediation analysis of inflammation indicators

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 13, 2025

Язык: Английский

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