Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons DOI Creative Commons
Greg J. Duncan, Tyrell J. Simkins, Ben Emery

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 9

Опубликована: Март 8, 2021

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction. Oligodendrocytes and have reciprocal signaling relationship in which receive cues from that direct their myelination, subsequently shape axonal structure conduction. are necessary for the maturation excitatory domains on axon including nodes Ranvier, help buffer potassium, support neuronal energy metabolism. Disruption oligodendrocyte-axon unit traumatic injuries, Alzheimer’s disease demyelinating diseases such as multiple sclerosis results dysfunction can culminate neurodegeneration. In this review, we discuss mechanisms demyelination loss compromise axons. We highlight intra-axonal cascades initiated result irreversible damage. Both restoration oligodendrocyte or neuroprotective therapies targeting these likely to therapeutic potential disorders disrupted.

Язык: Английский

White matter aging drives microglial diversity DOI Creative Commons
Shima Safaiyan, Simon Besson‐Girard, Tuğberk Kaya

и другие.

Neuron, Год журнала: 2021, Номер 109(7), С. 1100 - 1117.e10

Опубликована: Фев. 19, 2021

Язык: Английский

Процитировано

317

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome DOI Creative Commons
Dirk Fitzner, Jakob M. Bader, Horst Penkert

и другие.

Cell Reports, Год журнала: 2020, Номер 32(11), С. 108132 - 108132

Опубликована: Сен. 1, 2020

Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment mouse composition. We quantify around 700 species evaluate features including fatty acyl chain length, hydroxylation, number double bonds, thereby identifying cell-type- brain-region-specific profiles in adult mice, as well aged apolipoprotein-E-deficient model Alzheimer's disease, mice fed different diets. also integrate with to predict pathways enriched specific cell types, such acid β-oxidation astrocytes sphingolipid metabolism microglia. This resource complements existing atlases gene may be role lipids function.

Язык: Английский

Процитировано

206

Diagnosis and classification of optic neuritis DOI
Axel Petzold, Clare L. Fraser, Mathias Abegg

и другие.

The Lancet Neurology, Год журнала: 2022, Номер 21(12), С. 1120 - 1134

Опубликована: Сен. 27, 2022

Язык: Английский

Процитировано

181

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging DOI Creative Commons
Tuğberk Kaya, Nicola Mattugini, Lu Liu

и другие.

Nature Neuroscience, Год журнала: 2022, Номер 25(11), С. 1446 - 1457

Опубликована: Окт. 24, 2022

Abstract A hallmark of nervous system aging is a decline white matter volume and function, but the underlying mechanisms leading to pathology are unknown. In present study, we found age-related alterations oligodendrocyte cell state with reduction in total density murine matter. Using single-cell RNA-sequencing, identified interferon (IFN)-responsive oligodendrocytes, which localize proximity CD8 + T cells Absence functional lymphocytes decreased number IFN-responsive oligodendrocytes rescued loss, whereas T-cell checkpoint inhibition worsened response. addition, subpopulation lymphocyte-dependent, microglia vicinity summary, provide evidence that T-cell-induced, important modifiers aging.

Язык: Английский

Процитировано

143

Astrocytes: a double-edged sword in neurodegenerative diseases DOI Creative Commons
Yuqing Yan,

Cun-Gen Ma,

Zhibin Ding

и другие.

Neural Regeneration Research, Год журнала: 2021, Номер 16(9), С. 1702 - 1702

Опубликована: Янв. 1, 2021

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, sustaining neuroprotective effects. become activated as a result inflammatory responses during progression pathological changes associated with neurodegenerative disorders. Reactive astrocytes (neurotoxic A1 A2) are triggered disease pathogenesis due to neuroinflammation ischemia. However, only limited body literature describes morphological functional diseases. The present review investigated detrimental beneficial diseases reported recent studies, these cells have promising therapeutic potential offer new approaches for treatment

Язык: Английский

Процитировано

141

Periods of synchronized myelin changes shape brain function and plasticity DOI

Omar de Faria,

Helena Pivoňková, Balázs Varga

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(11), С. 1508 - 1521

Опубликована: Окт. 28, 2021

Язык: Английский

Процитировано

124

Myelin: A gatekeeper of activity-dependent circuit plasticity? DOI
Giulia Bonetto, David Belin, Ragnhildur Thóra Káradóttir

и другие.

Science, Год журнала: 2021, Номер 374(6569)

Опубликована: Ноя. 11, 2021

The brain is responsive to an ever-changing environment, enabling the organism learn and change behavior accordingly. Efforts understand underpinnings of this plasticity have almost exclusively focused on functional underlying structural changes that neurons undergo at neurochemical synapses. What has received comparatively little attention involvement activity-dependent myelination in such output circuits controlling behavior. traditionally held view myelin as a passive insulator axons changing one lifelong myelin, modulated by neuronal activity experience. We review nascent evidence role strengthening circuit functions underlie learning

Язык: Английский

Процитировано

114

Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment DOI Open Access
Silvia Triarico, Alberto Romano, Giorgio Attinà

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(8), С. 4112 - 4112

Опубликована: Апрель 16, 2021

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory, motor and/or autonomic, consequent reduction, delay or discontinuation vincristine-chemotherapy, but also pain, disability, reduced quality life and an increase in medical costs. Vincristine acts out its antineoplastic function by altering the normal assembly disassembly microtubules, their mitosis block death. leads to VIPN through complex mechanism damage, which occurs not only on endothelium mitochondria nerve cells. Furthermore, both patient-related risk factors (age, race, ethnicity genetic polymorphisms) treatment-related (dose, time infusion drug–drug interactions) are involved pathogenesis VIPN. There lack consensus about prophylaxis treatment oncologic patients, despite several molecules (such as gabapentin, pyridoxine pyridostigmine, glutamic acid glutamine) having been already investigated clinical trials. This review describes molecular mechanisms analyzes principal drugs adopted for

Язык: Английский

Процитировано

106

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities DOI Creative Commons
Robin J.M. Franklin, Mikael Simons

Neuron, Год журнала: 2022, Номер 110(21), С. 3549 - 3565

Опубликована: Окт. 12, 2022

Язык: Английский

Процитировано

92

Potential role of chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) in neurodegeneration and Alzheimer's disease DOI
Kevin Connolly,

Mikael Lehoux,

Ryan O’Rourke

и другие.

Alzheimer s & Dementia, Год журнала: 2022, Номер 19(1), С. 9 - 24

Опубликована: Март 2, 2022

Chitinase-3-like protein 1 (CHI3L1/YKL-40) has long been known as a biomarker for early detection of neuroinflammation and disease diagnosis Alzheimer's (AD). In the brain, CHI3L1 is primarily provided by astrocytes heralds reactive, neurotoxic state triggered inflammation other stress signals. However, how acts in or it contributes to AD relevant neurodegenerative conditions remains unknown. peripheral tissues, our group others have uncovered that master regulator wide range injury repair events, including innate immunity pathway resembles process governed microglia astrocytes. Based on assessment current knowledge regarding biology, we hypothesize functions signaling molecule mediating distinct neuroinflammatory responses brain cells misfunctions precipitate neurodegeneration. We also recommend future research directions validate such assertions better understanding mechanisms.

Язык: Английский

Процитировано

86