White matter aging drives microglial diversity

Neuron, Journal Year: 2021, Volume and Issue: 109(7), P. 1100 - 1117.e10

Published: Feb. 19, 2021

Language: Английский

---

Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome

Cell Reports, Journal Year: 2020, Volume and Issue: 32(11), P. 108132 - 108132

Published: Sept. 1, 2020

Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment mouse composition. We quantify around 700 species evaluate features including fatty acyl chain length, hydroxylation, number double bonds, thereby identifying cell-type- brain-region-specific profiles in adult mice, as well aged apolipoprotein-E-deficient model Alzheimer's disease, mice fed different diets. also integrate with to predict pathways enriched specific cell types, such acid β-oxidation astrocytes sphingolipid metabolism microglia. This resource complements existing atlases gene may be role lipids function.

Language: Английский

---

Diagnosis and classification of optic neuritis

The Lancet Neurology, Journal Year: 2022, Volume and Issue: 21(12), P. 1120 - 1134

Published: Sept. 27, 2022

Language: Английский

---

Astrocytes: a double-edged sword in neurodegenerative diseases

Neural Regeneration Research, Journal Year: 2021, Volume and Issue: 16(9), P. 1702 - 1702

Published: Jan. 1, 2021

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, sustaining neuroprotective effects. become activated as a result inflammatory responses during progression pathological changes associated with neurodegenerative disorders. Reactive astrocytes (neurotoxic A1 A2) are triggered disease pathogenesis due to neuroinflammation ischemia. However, only limited body literature describes morphological functional diseases. The present review investigated detrimental beneficial diseases reported recent studies, these cells have promising therapeutic potential offer new approaches for treatment

Language: Английский

---

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(11), P. 1446 - 1457

Published: Oct. 24, 2022

Abstract A hallmark of nervous system aging is a decline white matter volume and function, but the underlying mechanisms leading to pathology are unknown. In present study, we found age-related alterations oligodendrocyte cell state with reduction in total density murine matter. Using single-cell RNA-sequencing, identified interferon (IFN)-responsive oligodendrocytes, which localize proximity CD8 + T cells Absence functional lymphocytes decreased number IFN-responsive oligodendrocytes rescued loss, whereas T-cell checkpoint inhibition worsened response. addition, subpopulation lymphocyte-dependent, microglia vicinity summary, provide evidence that T-cell-induced, important modifiers aging.

Language: Английский

---

Periods of synchronized myelin changes shape brain function and plasticity

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(11), P. 1508 - 1521

Published: Oct. 28, 2021

Language: Английский

---

Myelin: A gatekeeper of activity-dependent circuit plasticity?

Science, Journal Year: 2021, Volume and Issue: 374(6569)

Published: Nov. 11, 2021

The brain is responsive to an ever-changing environment, enabling the organism learn and change behavior accordingly. Efforts understand underpinnings of this plasticity have almost exclusively focused on functional underlying structural changes that neurons undergo at neurochemical synapses. What has received comparatively little attention involvement activity-dependent myelination in such output circuits controlling behavior. traditionally held view myelin as a passive insulator axons changing one lifelong myelin, modulated by neuronal activity experience. We review nascent evidence role strengthening circuit functions underlie learning

Language: Английский

---

Vincristine-Induced Peripheral Neuropathy (VIPN) in Pediatric Tumors: Mechanisms, Risk Factors, Strategies of Prevention and Treatment

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(8), P. 4112 - 4112

Published: April 16, 2021

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory, motor and/or autonomic, consequent reduction, delay or discontinuation vincristine-chemotherapy, but also pain, disability, reduced quality life and an increase in medical costs. Vincristine acts out its antineoplastic function by altering the normal assembly disassembly microtubules, their mitosis block death. leads to VIPN through complex mechanism damage, which occurs not only on endothelium mitochondria nerve cells. Furthermore, both patient-related risk factors (age, race, ethnicity genetic polymorphisms) treatment-related (dose, time infusion drug–drug interactions) are involved pathogenesis VIPN. There lack consensus about prophylaxis treatment oncologic patients, despite several molecules (such as gabapentin, pyridoxine pyridostigmine, glutamic acid glutamine) having been already investigated clinical trials. This review describes molecular mechanisms analyzes principal drugs adopted for

Language: Английский

---

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Neuron, Journal Year: 2022, Volume and Issue: 110(21), P. 3549 - 3565

Published: Oct. 12, 2022

Language: Английский

---

Potential role of chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) in neurodegeneration and Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2022, Volume and Issue: 19(1), P. 9 - 24

Published: March 2, 2022

Chitinase-3-like protein 1 (CHI3L1/YKL-40) has long been known as a biomarker for early detection of neuroinflammation and disease diagnosis Alzheimer's (AD). In the brain, CHI3L1 is primarily provided by astrocytes heralds reactive, neurotoxic state triggered inflammation other stress signals. However, how acts in or it contributes to AD relevant neurodegenerative conditions remains unknown. peripheral tissues, our group others have uncovered that master regulator wide range injury repair events, including innate immunity pathway resembles process governed microglia astrocytes. Based on assessment current knowledge regarding biology, we hypothesize functions signaling molecule mediating distinct neuroinflammatory responses brain cells misfunctions precipitate neurodegeneration. We also recommend future research directions validate such assertions better understanding mechanisms.

Language: Английский

---