Neuron, Journal Year: 2022, Volume and Issue: 110(20), P. 3230 - 3242
Published: Sept. 8, 2022
Language: Английский
Science Advances, Journal Year: 2021, Volume and Issue: 7(30)
Published: July 21, 2021
Traveling waves spatiotemporally organize brain-wide activity in synchrony with ongoing arousal fluctuations.
Language: Английский
Citations
190
Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(8), P. 1059 - 1070
Published: July 7, 2022
Language: Английский
Citations
181
Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1050 - 1075
Published: April 1, 2023
Language: Английский
Citations
175
Brain, Journal Year: 2020, Volume and Issue: 143(8), P. 2341 - 2368
Published: March 2, 2020
Abstract Absence seizures in children and teenagers are generally considered relatively benign because of their non-convulsive nature the large incidence remittance early adulthood. Recent studies, however, show that 30% with absence pharmaco-resistant 60% affected by severe neuropsychiatric comorbid conditions, including impairments attention, cognition, memory mood. In particular, attention deficits can be detected before epilepsy diagnosis, may persist even when pharmacologically controlled aggravated valproic acid monotherapy. New functional MRI-magnetoencephalography MRI-EEG studies provide conclusive evidence changes blood oxygenation level-dependent signal amplitude frequency specific cortical networks at least 1 min start a seizure, spike-wave discharges not generalized seizure onset abnormal network states remain during interictal periods. From neurobiological perspective, recent electrical recordings imaging neuronal ensembles single-cell resolution non-anaesthetized models that, contrast to predominant opinion, mechanisms, rather than an exclusively thalamic rhythmogenesis, key driving ictogenesis determining frequency. Though synchronous ictal firing characterizes activity population level, individual cortico-thalamic thalamocortical neurons sparsely recruited successive consecutive paroxysmal cycles within seizure. strengthens previous findings on essential role for basal ganglia seizures, particular increase substantia nigra GABAergic neurons. Thus, feature is powerful inhibition originates from two sources, reticular nucleus. This undoubtedly provides major contribution decrease total T-type calcium channel-mediated burst neurons, though latter expression. Moreover, some animal enhanced loss-of-function astrocytic GABA transporter GAT-1 does necessarily derive mutation its gene. Together, these novel clinical experimental bring about paradigm-shifting views our understanding demand careful choice initial monotherapy continuous evaluation children. These issues discussed here focus future research help identify therapeutic targets treating both comorbidities.
Language: Английский
Citations
159
Current Biology, Journal Year: 2021, Volume and Issue: 31(22), P. 5009 - 5023.e7
Published: Oct. 14, 2021
To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred around mean levels greater than ones quiet wakefulness, while (NA) declined steeply REMS. They coincided clustering spindle rhythms forebrain heart-rate variations, both which are correlates arousability. We addressed origins these by using closed-loop optogenetic locus coeruleus (LC) activation or inhibition timed moments low high NREMS. suppress, lock, entrain sleep-spindle fore- hindbrain-projecting LC neurons show coordinated infraslow variations natural Noradrenergic modulation thalamic, but not cortical, circuits was required for involved NA release into primary reticular thalamic nuclei activated α1- β-adrenergic receptors cause slowly decaying membrane depolarizations. signaling constitutes vigilance-promoting mechanism renders mammalian disruption close-to-minute through sustaining thalamocortical autonomic arousability.Video abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading ...(mp4, 35.34 MB) Download video
Language: Английский
Citations
138
Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)
Published: May 25, 2021
Abstract Sleep is thought to support memory consolidation via reactivation of prior experiences, with particular electrophysiological sleep signatures (slow oscillations (SOs) and spindles) gating the information flow between relevant brain areas. However, empirical evidence for a role endogenous (i.e., without experimentally delivered cues) in humans lacking. Here, we devised paradigm which participants acquired associative memories before taking nap. Multivariate decoding was then used capture during non-rapid eye movement (NREM) surface EEG recordings. Our results reveal learning material SO-spindle complexes, precision coupling predicting strength. Critically, strength (i.e. classifier favor previously studied stimulus category) turn predicts level across participants. These elucidate function emphasize importance SOs spindles clocking processes.
Language: Английский
Citations
118
Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(8), P. 1429 - 1437
Published: July 10, 2023
Abstract Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain, in absence external stimulation or conscious effort, coordinates firing rates (FRs) communication within across to support synaptic systems consolidation. Using intracranial electroencephalography combined with multiunit activity recordings from human hippocampus surrounding medial temporal lobe (MTL) areas, we show that, governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples occur. This sequential coupling leads stepwise increase (1) FRs, (2) short-latency cross-correlations among local assemblies (3) cross-regional MTL interactions. Triggered SOs spindles, thus establish optimal conditions spike-timing-dependent These results unveil specific rhythms orchestrates processing sleep.
Language: Английский
Citations
62
Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 253 - 271
Published: March 5, 2024
Language: Английский
Citations
23
Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1568 - 1594
Published: May 1, 2024
Language: Английский
Citations
20
Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(4), P. 339 - 351
Published: March 4, 2024
How do passing moments turn into lasting memories? Sheltered from external tasks and distractions, sleep constitutes an optimal state for the brain to reprocess consolidate previous experiences. Recent work suggests that consolidation is governed by intricate interaction of slow oscillations (SOs), spindles, ripples – electrophysiological rhythms orchestrate neuronal processing communication within across memory circuits. This review describes how sequential SO–spindle–ripple coupling provides a temporally spatially fine-tuned mechanism selectively strengthen target memories hippocampal cortical networks. Coupled might be harnessed not only enhance overnight retention, but also combat decline associated with healthy ageing neurodegenerative diseases.
Language: Английский
Citations
19