Reduced recruitment of inhibitory control regions in very young children with ADHD during a modified Kiddie Continuous Performance Task: a fMRI study.

Cortex, Год журнала: 2025, Номер 185, С. 153 - 169

Опубликована: Фев. 25, 2025

Язык: Английский

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Emergent Aspects of the Integration of Sensory and Motor Functions

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 162 - 162

Опубликована: Фев. 7, 2025

This article delves into the intricate mechanisms underlying sensory integration in executive control of movement, encompassing ideomotor activity, predictive capabilities, and motor systems. It examines interplay between functions, highlighting role cortical subcortical regions central nervous system enhancing environmental interaction. The acquisition skills, procedural memory, representation actions brain are discussed emphasizing significance mental imagery training function. development this aspect sensorimotor can help to advance our understanding interactions control, mechanisms, consciousness. Bridging theoretical insights with practical applications, it sets stage for future innovations clinical rehabilitation, assistive technology, education. ongoing exploration these domains promises uncover new pathways human capability well-being.

Язык: Английский

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Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop

Science, Год журнала: 2025, Номер 388(6742)

Опубликована: Апрель 4, 2025

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it not clear how those and thalamocortical interactions directly contribute the transient process of human perception. We simultaneously recorded stereoelectroencephalography data from prefrontal cortex (PFC), while patients implanted electrodes performed a visual consciousness task. Compared ventral PFC, intralaminar medial presented earlier stronger consciousness-related activity. Transient thalamofrontal neural synchrony cross-frequency coupling were both driven by θ phase during The thus play gate role drive PFC emergence

Язык: Английский

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Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

Neuropharmacology, Год журнала: 2023, Номер 226, С. 109421 - 109421

Опубликована: Янв. 10, 2023

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in impaired decision-making and loss flexibility thoughts behaviors, which underlie behavioral deficits ranging from depression, obsessive-compulsive disorders drug addiction. Tackling the neuromodulators fine-tuning this core element may facilitate development effective strategies to control these present multiple psychiatric disorders. The current investigation has concentrated on dopamine glutamate signaling corticostriatal pathway. In accordance with beneficial effects caffeine intake mood cognitive dysfunction, we now propose that caffeine's main site action - adenosine A

Язык: Английский

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Distributed and specific encoding of sensory, motor, and decision information in the mouse neocortex during goal-directed behavior

Cell Reports, Год журнала: 2023, Номер 43(1), С. 113618 - 113618

Опубликована: Дек. 26, 2023

Goal-directed behaviors involve coordinated activity in many cortical areas, but whether the encoding of task variables is distributed across areas or more specifically represented distinct remains unclear. Here, we compared representations sensory, motor, and decision information whisker primary somatosensory cortex, medial prefrontal tongue-jaw motor cortex mice trained to lick response a stimulus with that were not taught this association. Irrespective learning, properties sensory best encoded whereas fine movement kinematics cortex. However, initiation all three neurons being selective, showing minimal responses miss trials during spontaneous licks. Our results reconcile previous studies indicating highly specific vs. sensorimotor processing.

Язык: Английский

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Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input

Cell Reports, Год журнала: 2024, Номер 43(8), С. 114483 - 114483

Опубликована: Июль 17, 2024

The striatum integrates dopaminergic and glutamatergic inputs to select preferred versus alternative actions. However, the precise mechanisms underlying this process remain unclear. One way study action selection is understand how it breaks down in pathological states. Here, we explored cellular synaptic of levodopa-induced dyskinesia (LID), a complication Parkinson's disease therapy characterized by involuntary movements. We used an activity-dependent tool (FosTRAP) conjunction with mouse model LID investigate functionally distinct subsets striatal direct pathway medium spiny neurons (dMSNs). In vivo, levodopa differentially activates dyskinesia-associated (TRAPed) dMSNs compared other dMSNs. found differential activation TRAPed likely be driven higher dopamine receptor expression, dopamine-dependent excitability, excitatory input from motor cortex thalamus. Together, these findings suggest intrinsic properties heterogeneous dMSN subpopulations integrate support selection.

Язык: Английский

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Structure, Function, and Genetics of the Cerebellum in Autism

Journal of Psychiatry and Brain Science, Год журнала: 2021, Номер unknown

Опубликована: Янв. 1, 2021

Autism spectrum disorders are common neurodevelopmental that defined by core behavioral symptoms but have diverse genetic and environmental risk factors. Despite its etiological heterogeneity, several unifying theories of autism been proposed, including a central role for cerebellar dysfunction. The cerebellum follows protracted course development culminates in an exquisitely crafted brain structure containing over half the neurons entire densely packed into highly organized structure. Through complex network connections with cortical subcortical regions, acts as sensorimotor regulator affects changes executive limbic processing. In this review, we summarize structural, functional, contributions to autism.

Язык: Английский

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Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging

Brain Research, Год журнала: 2025, Номер unknown, С. 149461 - 149461

Опубликована: Янв. 1, 2025

Язык: Английский

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Multimodality in the Collicular Pathway: Towards Compensatory Visual Processes

Cells, Год журнала: 2025, Номер 14(9), С. 635 - 635

Опубликована: Апрель 25, 2025

The integration of multisensory inputs plays a crucial role in shaping perception and behavior, particularly the visual system. collicular pathway, encompassing optic tectum non-mammalian vertebrates superior colliculus (SC) mammals, is key hub for integrating sensory information mediating adaptive motor responses. Comparative studies across species reveal evolutionary adaptations that enhance processing contribute to compensatory mechanisms following neuronal injury. present review outlines structure function pathways, emphasizing retinocollicular projections, their integration, which depends on synaptic convergence afferents conveying from different modalities. cellular underlying multimodal remain be fully clarified, further investigations are needed clarify link between activity response stimulation behavioral involving activity. By exploring interplay fundamental neuroscience translational applications, we aim address as pivotal target its potential rehabilitation strategies.

Язык: Английский

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Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala

Progress in Neurobiology, Год журнала: 2024, Номер 238, С. 102629 - 102629

Опубликована: Май 17, 2024

Язык: Английский

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