Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 21(7), С. 363 - 383

Опубликована: Март 30, 2020

Язык: Английский

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Mechanisms and disease consequences of nonalcoholic fatty liver disease

Cell, Год журнала: 2021, Номер 184(10), С. 2537 - 2564

Опубликована: Май 1, 2021

Язык: Английский

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Insulin Resistance: From Mechanisms to Therapeutic Strategies

Diabetes & Metabolism Journal, Год журнала: 2021, Номер 46(1), С. 15 - 37

Опубликована: Дек. 30, 2021

Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and defined as a state reduced responsiveness insulin-targeting tissues to physiological levels insulin. Although underlying mechanism insulin not fully understood, several credible theories have been proposed. In this review, we summarize functions in glucose metabolism typical describe mechanisms proposed underlie resistance, that is, ectopic lipid accumulation liver skeletal muscle, endoplasmic reticulum stress, inflammation. addition, suggest potential therapeutic strategies for addressing resistance.

Язык: Английский

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Adipose-tissue plasticity in health and disease

Cell, Год журнала: 2022, Номер 185(3), С. 419 - 446

Опубликована: Фев. 1, 2022

Язык: Английский

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The endocrine function of adipose tissues in health and cardiometabolic disease

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(9), С. 507 - 524

Опубликована: Июль 11, 2019

Язык: Английский

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Obesity and dyslipidemia

Metabolism, Год журнала: 2018, Номер 92, С. 71 - 81

Опубликована: Ноя. 14, 2018

Язык: Английский

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Why does obesity cause diabetes?

Cell Metabolism, Год журнала: 2022, Номер 34(1), С. 11 - 20

Опубликована: Янв. 1, 2022

Язык: Английский

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Lipolysis: cellular mechanisms for lipid mobilization from fat stores

Nature Metabolism, Год журнала: 2021, Номер 3(11), С. 1445 - 1465

Опубликована: Ноя. 19, 2021

Язык: Английский

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NAFLD and cardiovascular diseases: a clinical review

Clinical Research in Cardiology, Год журнала: 2020, Номер 110(7), С. 921 - 937

Опубликована: Июль 21, 2020

Abstract Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic disease in Western countries and affects approximately 25% of adult population. Since NAFLD frequently associated with further metabolic comorbidities such as obesity, type 2 diabetes mellitus, or dyslipidemia, it generally considered hepatic manifestation syndrome. In addition to its potential cause liver-related morbidity mortality, also subclinical clinical cardiovascular (CVD). Growing evidence indicates that patients are at substantial risk for development hypertension, coronary heart disease, cardiomyopathy, cardiac arrhythmias, which clinically result increased mortality. The natural history variable vast majority will not progress from simple steatosis fibrosis end stage disease. However, progressive forms NAFLD, including non-alcoholic steatohepatitis (NASH) and/or advanced fibrosis, well concomitant types highest CVD. This review describes underlying pathophysiological mechanisms linking CVD, discusses role a dysfunction factor, focuses on manifestations patients.

Язык: Английский

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Complications, morbidity and mortality of nonalcoholic fatty liver disease

Metabolism, Год журнала: 2020, Номер 111, С. 154170 - 154170

Опубликована: Янв. 30, 2020

Язык: Английский

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