Biomolecules,
Journal Year:
2019,
Volume and Issue:
9(3), P. 99 - 99
Published: March 12, 2019
Type
2
diabetes
mellitus
(T2DM)
is
a
metabolic
disease
characterized
by
insulin
resistance
and
hyperglycemia
associated
with
personal
health
global
economic
burdens.
Current
strategies/approaches
of
T2DM
prevention
treatment
are
lacking
in
efficacy
resulting
the
need
for
new
preventative
targeted
therapies.
In
recent
years,
epidemiological
studies
have
suggested
that
diets
rich
vegetables
fruits
benefits
including
protection
against
T2DM.
Naringenin,
citrus
flavanone,
has
been
reported
to
antioxidant,
anti-inflammatory,
hepatoprotective,
nephroprotective,
immunomodulatory
antidiabetic
properties.
The
current
review
summarizes
existing
vitro
vivo
animal
examining
anti-diabetic
effects
naringenin.
Diabetes & Metabolism Journal,
Journal Year:
2021,
Volume and Issue:
46(1), P. 15 - 37
Published: Dec. 30, 2021
Insulin
resistance
is
the
pivotal
pathogenic
component
of
many
metabolic
diseases,
including
type
2
diabetes
mellitus,
and
defined
as
a
state
reduced
responsiveness
insulin-targeting
tissues
to
physiological
levels
insulin.
Although
underlying
mechanism
insulin
not
fully
understood,
several
credible
theories
have
been
proposed.
In
this
review,
we
summarize
functions
in
glucose
metabolism
typical
describe
mechanisms
proposed
underlie
resistance,
that
is,
ectopic
lipid
accumulation
liver
skeletal
muscle,
endoplasmic
reticulum
stress,
inflammation.
addition,
suggest
potential
therapeutic
strategies
for
addressing
resistance.
Clinical Research in Cardiology,
Journal Year:
2020,
Volume and Issue:
110(7), P. 921 - 937
Published: July 21, 2020
Abstract
Non-alcoholic
fatty
liver
DISEASE
(NAFLD)
is
the
most
common
chronic
disease
in
Western
countries
and
affects
approximately
25%
of
adult
population.
Since
NAFLD
frequently
associated
with
further
metabolic
comorbidities
such
as
obesity,
type
2
diabetes
mellitus,
or
dyslipidemia,
it
generally
considered
hepatic
manifestation
syndrome.
In
addition
to
its
potential
cause
liver-related
morbidity
mortality,
also
subclinical
clinical
cardiovascular
(CVD).
Growing
evidence
indicates
that
patients
are
at
substantial
risk
for
development
hypertension,
coronary
heart
disease,
cardiomyopathy,
cardiac
arrhythmias,
which
clinically
result
increased
mortality.
The
natural
history
variable
vast
majority
will
not
progress
from
simple
steatosis
fibrosis
end
stage
disease.
However,
progressive
forms
NAFLD,
including
non-alcoholic
steatohepatitis
(NASH)
and/or
advanced
fibrosis,
well
concomitant
types
highest
CVD.
This
review
describes
underlying
pathophysiological
mechanisms
linking
CVD,
discusses
role
a
dysfunction
factor,
focuses
on
manifestations
patients.
