Focus on prolactin as a metabolic hormone

Trends in Endocrinology and Metabolism, Год журнала: 2006, Номер 17(3), С. 110 - 116

Опубликована: Март 7, 2006

Язык: Английский

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Prolactin: A Pleiotropic Neuroendocrine Hormone

Journal of Neuroendocrinology, Год журнала: 2008, Номер 20(6), С. 752 - 763

Опубликована: Июнь 1, 2008

The neuroendocrine control of prolactin secretion is unlike that any other pituitary hormone. It predominantly inhibited by the hypothalamus and, in absence a regulatory feedback hormone, it acts directly brain to suppress its own secretion. In addition this short‐loop action brain, has been reported influence wide range functions. There have few attempts rationalise why single hormone might exert such distinct and seemingly unrelated review, we highlight some original studies first characterised unusual features neuroendocrinology, then attempt identify areas new progress and/or controversy. Finally, discuss hypothesis provides unifying explanation for pleiotrophic actions brain.

Язык: Английский

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60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-prolactin axis

Journal of Endocrinology, Год журнала: 2015, Номер 226(2), С. T101 - T122

Опубликована: Июнь 22, 2015

The hypothalamic control of prolactin secretion is different from other anterior pituitary hormones, in that it predominantly inhibitory, by means dopamine the tuberoinfundibular neurons. In addition, does not have an endocrine target tissue, and therefore lacks classical feedback pathway to regulate its secretion. Instead, regulated short loop feedback, whereby itself acts brain stimulate production thereby inhibit own Finally, despite relatively simple name, has a broad range functions body, addition defining role promoting lactation. As such, hypothalamo-prolactin axis many characteristics are quite distinct hypothalamo-pituitary systems. This review will provide brief overview our current understanding neuroendocrine secretion, particular focusing on plasticity evident this system, which keeps at low levels most time, but enables extended periods hyperprolactinemia when necessary for Key beyond milk be discussed, particularly inducing adaptive responses multiple systems facilitate lactation, consequences if action impaired. A feature pleiotropic activity may lactating state might maladaptive elevated inappropriately. Overall, my goal give flavour both history field neuroendocrinology, identify some exciting new areas research development.

Язык: Английский

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Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging

Frontiers in Neuroendocrinology, Год журнала: 2009, Номер 30(3), С. 343 - 357

Опубликована: Апрель 9, 2009

Язык: Английский

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Neuroanatomy of the extended circadian rhythm system

Experimental Neurology, Год журнала: 2012, Номер 243, С. 4 - 20

Опубликована: Июль 2, 2012

Язык: Английский

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