Ferroptosis: molecular mechanisms and health implications

Cell Research, Год журнала: 2020, Номер 31(2), С. 107 - 125

Опубликована: Дек. 2, 2020

Abstract Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form non-apoptotic cell in 2012, there has been mounting interest process and function ferroptosis. Ferroptosis occur two major pathways, extrinsic or transporter-dependent pathway intrinsic enzyme-regulated pathway. is caused by a redox imbalance between production oxidants antioxidants, which driven abnormal expression activity multiple redox-active enzymes that produce detoxify free radicals lipid oxidation products. Accordingly, precisely regulated at levels, including epigenetic, transcriptional, posttranscriptional posttranslational layers. The transcription factor NFE2L2 plays central role upregulating anti-ferroptotic defense, whereas selective autophagy may promote ferroptotic death. Here, we review current knowledge on integrated molecular machinery describe how dysregulated involved cancer, neurodegeneration, tissue injury, inflammation, infection.

Язык: Английский

---

Targeting Ferroptosis to Iron Out Cancer

Cancer Cell, Год журнала: 2019, Номер 35(6), С. 830 - 849

Опубликована: Май 16, 2019

Язык: Английский

---

Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges

Analytical Biochemistry, Год журнала: 2016, Номер 524, С. 13 - 30

Опубликована: Окт. 24, 2016

Язык: Английский

---

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Oxidative Medicine and Cellular Longevity, Год журнала: 2019, Номер 2019, С. 1 - 13

Опубликована: Окт. 13, 2019

Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates chain reactions, subsequently induces different types death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how propagate reactions products initiate apoptosis autophagy current models. We also during ferroptosis, summarized pathological conditions illness. aim bring more global integrative sight know ROS-induced occurs among

Язык: Английский

---

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Circulation Research, Год журнала: 2018, Номер 122(6), С. 877 - 902

Опубликована: Март 15, 2018

Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes subcellular compartments that typically produce ROS associated with metabolic regulation, diseases dysfunction may be influenced by changes redox balance. In this review, we summarize the current literature surrounding inflammatory focusing on transduction its relationship to disease progression. particular, examine production such as cytoplasm, mitochondria, peroxisome, endoplasmic reticulum discuss how influence processes proteasome function, autophagy, general signaling. We also highlight of regulation metabolic/inflammatory including atherosclerosis, diabetes mellitus, stroke. order develop therapies target oxidative signaling, it is vital understand balance signaling plays physiology pathophysiology, manipulation identity cellular tissue homeostasis. An increased understanding specific sources an appreciation metabolism help guide us effort treat cardiovascular diseases.

Язык: Английский

---

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Redox Biology, Год журнала: 2019, Номер 23, С. 101107 - 101107

Опубликована: Янв. 12, 2019

The transcription factor nuclear erythroid 2-related 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling expression genes that counteract oxidative and electrophilic stresses. Many pathological conditions are linked to imbalances in redox homeostasis, illustrating important role defense systems preventing pathogenic effects associated with accumulation reactive species. In particular, it becoming increasingly apparent lipid peroxides has an driving pathogenesis multiple disease states. A example this recent discovery novel form cell death termed ferroptosis. Ferroptosis iron-dependent, peroxidation-driven cascade become target development anti-cancer therapies, as well prevention neurodegenerative cardiovascular diseases. review, we will provide brief overview peroxidation, components involved ferroptotic cascade. We also highlight NRF2 signaling pathway mediating peroxidation ferroptosis, focusing on established mitigate these pathways, relevance NRF2-lipid peroxidation-ferroptosis axis disease.

Язык: Английский

---

Lipid peroxidation in cell death

Biochemical and Biophysical Research Communications, Год журнала: 2017, Номер 482(3), С. 419 - 425

Опубликована: Янв. 1, 2017

Disruption of redox homeostasis is a key phenotype many pathological conditions. Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized mediators and inducers oxidative stress, increasingly, attention focused on the role lipid hydroperoxides critical death disease. As main component cellular membranes, lipids have an indispensible in maintaining structural integrity cells. Excessive oxidation alters physical properties membranes can cause covalent modification proteins nucleic acids. This review discusses synthesis, toxicity, degradation, detection peroxides biological systems. Additionally, peroxidation highlighted cell disease, strategies to control accumulation discussed.

Язык: Английский

---

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Frontiers in Physiology, Год журнала: 2020, Номер 11

Опубликована: Июль 2, 2020

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative and cancer. Long term exposure to increased levels pro-oxidant factors can cause structural defects at a mitochondrial DNA level, well functional alteration several enzymes cellular structures leading aberrations gene expression. The modern lifestyle associated with processed food, wide range chemicals lack exercise important oxidative induction. However, use medicinal plants antioxidant properties has been exploited for their ability treat or prevent human pathologies which seems be one causes. In this review we discuss is triggers plant-derived compounds mechanisms defenses that help prevention these diseases. Finally, both beneficial detrimental effects molecules are used reduce conditions discussed.

Язык: Английский

---

Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal

Plants, Год журнала: 2019, Номер 8(4), С. 96 - 96

Опубликована: Апрель 11, 2019

Eight selected wild vegetables from Nepal (Alternanthera sessilis, Basella alba, Cassia tora, Digera muricata, Ipomoea aquatica, Leucas cephalotes, Portulaca oleracea and Solanum nigrum) were investigated for their antioxidative potential using 2,2-dyphenyl-1-picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), ferric reducing antioxidant power (FRAP), thiocyanate (FTC) methods. Among the plant extracts C. tora displayed highest DPPH radical scavenging activity with an IC50 value 9.898 μg/mL, whereas A. sessilis had maximum H2O2 16.25 μg/mL—very close to that of ascorbic acid (16.26 μg/mL). showed absorbance in FRAP assay lowest lipid peroxidation FTC assay. A methanol extract resulted greatest phenolic content (292.65 ± 0.42 mg gallic equivalent (GAE)/g) measured by Folin–Ciocalteu reagent method, while smallest was recorded B. alba (72.66 0.46 GAE/g). The flavonoid observed P. (39.38 0.57 quercetin equivalents (QE)/g) as aluminium chloride colorimetric least I. aquatica (6.61 QE/g). There a strong correlation between total (DPPH, R2 = 0.75; H2O2, 0.71) 0.84; 0.66). This study demonstrates these edible leafy plants could be source natural antioxidants.

Язык: Английский

---

Ferroptosis: mechanisms and links with diseases

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Фев. 3, 2021

Abstract Ferroptosis is an iron-dependent cell death, which different from apoptosis, necrosis, autophagy, and other forms of death. The process ferroptotic death defined by the accumulation lethal lipid species derived peroxidation lipids, can be prevented iron chelators (e.g., deferiprone, deferoxamine) small lipophilic antioxidants ferrostatin, liproxstatin). This review summarizes current knowledge about regulatory mechanism ferroptosis its association with several pathways, including iron, lipid, cysteine metabolism. We have further discussed contribution to pathogenesis diseases such as cancer, ischemia/reperfusion, various neurodegenerative Alzheimer’s disease Parkinson’s disease), evaluated therapeutic applications inhibitors in clinics.

Язык: Английский

---