Arthritis Research & Therapy,
Год журнала:
2022,
Номер
24(1)
Опубликована: Июль 22, 2022
Osteoarthritis
(OA)
is
an
age-related
cartilage
degenerative
disease,
and
chondrocyte
senescence
has
been
extensively
studied
in
recent
years.
Increased
numbers
of
senescent
chondrocytes
are
found
OA
cartilage.
Selective
clearance
a
post-traumatic
osteoarthritis
(PTOA)
mouse
model
ameliorated
development,
while
intraarticular
injection
cells
induced
OA.
However,
the
means
extent
to
which
affects
remain
unclear.
Here,
we
review
latent
mechanism
propose
potential
therapeutic
methods
target
OA-related
senescence,
with
emphasis
on
immunotherapies.
Natural
killer
(NK)
participate
elimination
multiple
organs.
A
relatively
comprehensive
discussion
presented
that
section.
Risk
factors
for
ageing,
obesity,
metabolic
disorders
mechanical
overload.
Determining
relationship
between
known
risk
will
help
elucidate
pathogenesis
identify
optimal
treatments.
International Journal of Molecular Sciences,
Год журнала:
2019,
Номер
20(10), С. 2374 - 2374
Опубликована: Май 14, 2019
Age-related
macular
degeneration
(AMD)
is
a
complex
eye
disease
that
affects
millions
of
people
worldwide
and
the
main
reason
for
legal
blindness
vision
loss
in
elderly
developed
countries.
Although
cause
AMD
pathogenesis
not
known,
oxidative
stress-related
damage
to
retinal
pigment
epithelium
(RPE)
considered
an
early
event
induction.
However,
precise
such
induction
stress,
including
related
effects
occurring
RPE
onset
progression
AMD,
are
well
understood.
Many
results
point
mitochondria
as
source
elevated
levels
reactive
oxygen
species
(ROS)
AMD.
This
ROS
increase
can
be
associated
with
aging
induced
by
other
risk
factors
correlated
mitochondrial
DNA.
Therefore,
DNA
(mtDNA)
essential
element
pathogenesis.
supported
many
studies
show
greater
susceptibility
mtDNA
than
nuclear
DNA-damaging
agents
reaction
(mtDDR)
important
prevention
slowing
down
its
ROS-targeting
therapy.
we
know
far
less
about
counterparts.
Further
research
should
measure
order
compare
it
nucleus,
current
methods
have
serious
disadvantages.
Cardiovascular Research,
Год журнала:
2021,
Номер
118(5), С. 1173 - 1187
Опубликована: Май 5, 2021
Abstract
Cellular
senescence
is
a
state
of
irreversible
cell
cycle
arrest
associated
with
ageing.
Senescence
different
cardiac
types
can
direct
the
pathophysiology
cardiovascular
diseases
(CVDs)
such
as
atherosclerosis,
myocardial
infarction,
and
fibrosis.
While
age-related
telomere
shortening
represents
major
cause
replicative
senescence,
senescent
also
be
induced
by
oxidative
stress,
metabolic
dysfunction,
epigenetic
regulation,
among
other
stressors.
It
critical
that
we
understand
molecular
pathways
lead
to
cellular
consequences
in
order
develop
new
therapeutic
approaches
treat
CVD.
In
this
review,
discuss
mechanisms
explore
how
(including
cardiomyocytes,
endothelial
cells,
fibroblasts,
vascular
smooth
muscle
valve
interstitial
cells)
CVD,
highlight
potential
target
prevent
or
Journal of Immunology Research,
Год журнала:
2022,
Номер
2022, С. 1 - 12
Опубликована: Март 23, 2022
Oxidative
stress
plays
an
important
role
in
the
development
of
aging-related
diseases
by
accelerating
lipid
peroxidation
polyunsaturated
fatty
acids
cell
membrane,
resulting
production
aldehydes,
such
as
malondialdehyde
and
4-hydroxy-2-nonenal
(4-HNE)
other
toxic
substances.
The
compound
4-HNE
forms
adducts
with
DNA
or
proteins,
disrupting
many
signaling
pathways
including
regulation
apoptosis
signal
transduction
pathways.
binding
proteins
to
(4-HNE-protein)
acts
marker
peroxidation,
its
increasing
concentration
brain
tissues
fluids
because
aging,
ultimately
gives
rise
some
hallmark
disorders,
neurodegenerative
(Alzheimer’s
Parkinson’s
diseases),
ophthalmic
(dry
eye,
macular
degeneration),
hearing
loss,
cancer.
This
review
aims
describe
physiological
origin
4-HNE,
elucidate
toxicity
diseases,
discuss
detoxifying
effect
aldehyde
dehydrogenase
glutathione
4-HNE-driven
diseases.
Arthritis Research & Therapy,
Год журнала:
2022,
Номер
24(1)
Опубликована: Июль 22, 2022
Osteoarthritis
(OA)
is
an
age-related
cartilage
degenerative
disease,
and
chondrocyte
senescence
has
been
extensively
studied
in
recent
years.
Increased
numbers
of
senescent
chondrocytes
are
found
OA
cartilage.
Selective
clearance
a
post-traumatic
osteoarthritis
(PTOA)
mouse
model
ameliorated
development,
while
intraarticular
injection
cells
induced
OA.
However,
the
means
extent
to
which
affects
remain
unclear.
Here,
we
review
latent
mechanism
propose
potential
therapeutic
methods
target
OA-related
senescence,
with
emphasis
on
immunotherapies.
Natural
killer
(NK)
participate
elimination
multiple
organs.
A
relatively
comprehensive
discussion
presented
that
section.
Risk
factors
for
ageing,
obesity,
metabolic
disorders
mechanical
overload.
Determining
relationship
between
known
risk
will
help
elucidate
pathogenesis
identify
optimal
treatments.
