Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update

Molecules, Год журнала: 2021, Номер 26(14), С. 4380 - 4380

Опубликована: Июль 20, 2021

Low-grade chronic inflammation (LGCI) and oxidative stress act as cooperative synergistic partners in the pathogenesis of a wide variety diseases. Polyphenols, including anthocyanins, are involved regulating inflammatory state activating endogenous antioxidant defenses. Anthocyanins' effects on markers promising may have potential to exert an anti-inflammatory effect vitro vivo. Therefore, translating these research findings into clinical practice would effectively contribute prevention treatment disease. The present narrative review summarizes results studies from last 5 years context anti-oxidative role anthocyanins both health There is evidence indicate that supplementation regulation pro-inflammatory among healthy disease population. Although inconsistencies between result randomized control trials (RCTs) meta-analyses were also observed. Regarding anthocyanins' markers, there need for long-term allowing quantifiable progression inflammation. can help clinicians other care professionals understand importance use patients with

Язык: Английский

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Psoriasis: What Is New in Markers of Disease Severity?

Medicina, Год журнала: 2024, Номер 60(2), С. 337 - 337

Опубликована: Фев. 18, 2024

. Psoriasis is a chronic inflammatory skin disease and the result of interaction between numerous external internal factors. presents wide range manifestations encompassing individual lesions varying from pinpoint to large plaques that can evolve into generalised forms. The mirror pathophysiological mechanisms involved in psoriasis pathogenesis, such as inflammation, dysregulation immune response, uncontrolled proliferation keratinocytes angiogenesis. In this article, we present latest advances achieved regarding markers correlate with severity.

Язык: Английский

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Enhanced Inflammation and Nitrosative Stress in the Saliva and Plasma of Patients with Plaque Psoriasis

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(3), С. 745 - 745

Опубликована: Март 10, 2020

Psoriasis is the most common inflammatory skin disease, characterized by release of proinflammatory cytokines from lymphocytes, keratinocytes, and dendritic cells. Although psoriasis considered an immune-mediated its effect on secretory activity salivary glands quantitative composition saliva still unknown. The aim this study was to evaluate secretion as well several selected inflammation nitrosative stress biomarkers in unstimulated stimulated plasma patients. We demonstrated that, with progressing severity duration function parotid submandibular lost, which manifested decreased reduced amylase total protein concentration. levels tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interferon-gamma (INF-γ) were significantly higher, whereas interleukin-10 (IL-10) content considerably lower patients compared controls, changes increased disease duration. Similarly, we observed that intensity depended disease. By means receiver operating characteristic (ROC) analysis, showed evaluation nitric oxide (NO), nitrotyrosine, IL-2 concentration non-stimulated high sensitivity specificity differentiated basis rate (normal salivation vs. hyposalivation). In summary, dysfunction caused stress.

Язык: Английский

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Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

Nutrients, Год журнала: 2020, Номер 12(6), С. 1841 - 1841

Опубликована: Июнь 20, 2020

Psoriasis is a common, chronic, hyperproliferative, inflammatory skin disease occurring in most ethnic groups the world. The hereditary but process of its inheritance complex and still not fully understood. At same time, it has been observed that psoriatic lesions may be triggered by certain prooxidative external factors: using narcotics, smoking, drinking alcohol, physical mental stress, as well bacterial infections injury. Since main physiological marker psoriasis relates to disorders organism’s antioxidative system, necessary develop well-balanced combination pharmaceuticals dietary antioxidants facilitate effective treatment and/or prevention disease. sources must adequate for chronic use regardless patient’s age easily available, e.g., ingredients regular food or supplements. Diet manipulation promising therapeutic approach context modulating incidence diseases. Another potentially viable method entails nutrigenomics, which guarantees multiaspectual problem, including, particular, analyses genetic profiles patients with view more accurately targeting key problems. present paper pertains significance redox equilibrium psoriasis. Based on information published worldwide literature over last decade, impact exogenous course this was analysed.

Язык: Английский

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A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(4), С. 976 - 976

Опубликована: Апрель 1, 2020

This is the first study to evaluate both antioxidant barrier, glutathione metabolism, and oxidative damage proteins lipids in morbidly obese patients undergoing bariatric treatment. The included 65 with class 3 obesity divided into two subgroups: without metabolic syndrome (OB) (OB + MS). Blood samples were collected before surgery as well one, three, six, twelve months after Superoxide dismutase reduced (GSH) significantly decreased, whereas reductase uric acid enhanced compared lean control. Moreover, OB group, we observed increase of superoxide (SOD) decrease (UA) treatment; however, these changes not MS group. (advanced glycation end products, AGE; advanced oxidation protein AOPP) (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher patients. We noticed that AGE AOPP levels diminished treatment, redox status (ratio GSH oxidized glutathione) still Summarizing, morbid associated disturbances barrier lipids. Although improves homeostasis patients, those show a continuous status. In supplementation may be considered.

Язык: Английский

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Salivary Biomarkers of Oxidative Stress and Inflammation in Stroke Patients: From Basic Research to Clinical Practice

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Cerebral stroke is a serious worldwide health problem, as can be seen by the global epidemic of disease. In this disorder, when blood flow compromised ruptures or blocked arteries, sudden death neurons observed result lack oxygen and nutrients. Numerous severe problems frequent complications also exist in patients; therefore, there an urgent need to develop new therapeutic, diagnostic, prognostic methods for At present, diagnosis based on neurological examination, medical history, neuroimaging, due fact that rapid noninvasive diagnostic tests are unavailable. Nevertheless, oxidative stress inflammation considered key factors pathogenesis. Oxygen free radicals responsible oxidation lipids, proteins, DNA/RNA, which turn contributes damage brain. Toxic products reactions act cytostatically cell damaging membranes leading neuronal apoptosis necrosis. Thus, it seems redox/inflammatory biomarkers might used Nowadays, saliva increasing interest clinical laboratory medicine. Redox could obtained easily, noninvasively, cheaply, stress‐free from saliva. This minireview aimed at presenting current knowledge concerning use salivary prognosis stroke.

Язык: Английский

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ACSL4 is overexpressed in psoriasis and enhances inflammatory responses by activating ferroptosis

Biochemical and Biophysical Research Communications, Год журнала: 2022, Номер 623, С. 1 - 8

Опубликована: Июль 14, 2022

Язык: Английский

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Progress in salivary glands: Endocrine glands with immune functions

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Фев. 3, 2023

The production and secretion of saliva is an essential function the salivary glands. Saliva a complicated liquid with different functions, including moistening, digestion, mineralization, lubrication, mucosal protection. This review focuses on mechanism neural regulation secretion, secreted in response to various stimuli, odor, taste, vision, mastication. chemical physical properties change dynamically during physiological pathophysiological processes. Moreover, central nervous system modulates via neurotransmitters neuroreceptors. Smell, taste have been investigated for connection between salivation brain function. immune endocrine functions glands explored recently. Salivary play role innate adaptive immunity Various cells such as B cells, T macrophages, dendritic well immunoglobins like IgA IgG found Evidence supports synthesis corticosterone, testosterone, melatonin contains many potential biomarkers derived from epithelial gingival crevicular fluid, serum. High level matrix metalloproteinases cytokines are markers oral carcinoma, infectious disease cavity, systemic disease. Further research required monitor predict health clinical practice precision medicine.

Язык: Английский

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Nitrosative Stress Biomarkers in the Non-Stimulated and Stimulated Saliva, as well as Gingival Crevicular Fluid of Patients with Periodontitis: Review and Clinical Study

Antioxidants, Год журнала: 2020, Номер 9(3), С. 259 - 259

Опубликована: Март 21, 2020

Diagnosis of periodontopathy is complex and includes defining the cause, type, stage, grade periodontitis. Therefore, alternative diagnostic methods are sought to indicate progression inflammation or determine effectiveness therapy. Gingival crevicular fluid (GCF) biomarkers can be particularly useful because they most likely reflect disease process periodontal tissues. However, difficulty collecting GCF for testing reason limited use in diagnostics. Because periodontitis primary source nitrogen free radicals oral cavity, aim study was evaluate nitrosative stress (nitric oxide, peroxynitrite, S-nitrosothiols) GCF, non-stimulated stimulated saliva 90 patients with The group divided into two subgroups, depending on stage severity. We showed a significantly higher concentration all assessed significant changes has been shown only peroxynitrite. studied did not correlate clinical status, which probably results from their short-duration activity impact few factors cavity. Saliva gingival very differential diagnosis

Язык: Английский

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Salivary Gland Dysfunction, Protein Glycooxidation and Nitrosative Stress in Children with Chronic Kidney Disease

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(5), С. 1285 - 1285

Опубликована: Апрель 29, 2020

This study is the first to evaluate protein glycooxidation products, lipid oxidative damage and nitrosative stress in non-stimulated (NWS) stimulated whole saliva (SWS) of children with chronic kidney disease (CKD) divided into two subgroups: normal salivary secretion (n = 18) hyposalivation (NWS flow < 0.2 mL min−1; n 12). Hyposalivation was observed all patients severe renal failure (4–5 stage CKD), while > mL/min mild-moderate CKD (1–3 stage) controls. Salivary amylase activity total content were significantly lower compared control group. The fluorescence products (kynurenine, N-formylkynurenine, advanced glycation end products), lipids (4-hydroxynonneal, 8-isoprostanes) (peroxynitrite, nitrotyrosine) higher NWS, SWS, plasma healthy In group, oxidation correlated negatively rate, α-amylase content; however, do not reflect their level. conclusion, suffer from gland dysfunction. Oxidation proteins increases progression deterioration function.

Язык: Английский

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