Nitrosative Stress Biomarkers in the Non-Stimulated and Stimulated Saliva, as well as Gingival Crevicular Fluid of Patients with Periodontitis: Review and Clinical Study

Antioxidants, Год журнала: 2020, Номер 9(3), С. 259 - 259

Опубликована: Март 21, 2020

Diagnosis of periodontopathy is complex and includes defining the cause, type, stage, grade periodontitis. Therefore, alternative diagnostic methods are sought to indicate progression inflammation or determine effectiveness therapy. Gingival crevicular fluid (GCF) biomarkers can be particularly useful because they most likely reflect disease process periodontal tissues. However, difficulty collecting GCF for testing reason limited use in diagnostics. Because periodontitis primary source nitrogen free radicals oral cavity, aim study was evaluate nitrosative stress (nitric oxide, peroxynitrite, S-nitrosothiols) GCF, non-stimulated stimulated saliva 90 patients with The group divided into two subgroups, depending on stage severity. We showed a significantly higher concentration all assessed significant changes has been shown only peroxynitrite. studied did not correlate clinical status, which probably results from their short-duration activity impact few factors cavity. Saliva gingival very differential diagnosis

Язык: Английский

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Salivary Gland Dysfunction, Protein Glycooxidation and Nitrosative Stress in Children with Chronic Kidney Disease

Journal of Clinical Medicine, Год журнала: 2020, Номер 9(5), С. 1285 - 1285

Опубликована: Апрель 29, 2020

This study is the first to evaluate protein glycooxidation products, lipid oxidative damage and nitrosative stress in non-stimulated (NWS) stimulated whole saliva (SWS) of children with chronic kidney disease (CKD) divided into two subgroups: normal salivary secretion (n = 18) hyposalivation (NWS flow < 0.2 mL min−1; n 12). Hyposalivation was observed all patients severe renal failure (4–5 stage CKD), while > mL/min mild-moderate CKD (1–3 stage) controls. Salivary amylase activity total content were significantly lower compared control group. The fluorescence products (kynurenine, N-formylkynurenine, advanced glycation end products), lipids (4-hydroxynonneal, 8-isoprostanes) (peroxynitrite, nitrotyrosine) higher NWS, SWS, plasma healthy In group, oxidation correlated negatively rate, α-amylase content; however, do not reflect their level. conclusion, suffer from gland dysfunction. Oxidation proteins increases progression deterioration function.

Язык: Английский

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The Effect of Selected Dental Materials Used in Conservative Dentistry, Endodontics, Surgery, and Orthodontics as Well as during the Periodontal Treatment on the Redox Balance in the Oral Cavity

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(24), С. 9684 - 9684

Опубликована: Дек. 18, 2020

Oxidative stress (OS) is a redox homeostasis disorder that results in oxidation of cell components and thus disturbs metabolism. OS induced by numerous internal as well external factors. According to recent studies, dental treatment may also be one them. The aim our work was assess the effect on balance oral cavity. We reviewed literature available PubMed, Medline, Scopus databases, including from 2010 2020. Publications were searched according keywords: oxidative monomers; amalgam; periodontitis, braces, titanium; implants, endodontics treatment, treatment; composite. It found with use composites, amalgams, glass-ionomers, materials for root canal filling/rinsing, orthodontic braces (made various metal alloys), titanium or whitening agents can disturb affecting antioxidant barrier increasing damage salivary proteins, lipids, DNA. Abnormal saliva secretion/composition observed patients course OS. suggested addition antioxidants therapy applied during could protect patient against harmful effects

Язык: Английский

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Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

Antioxidants, Год журнала: 2020, Номер 9(5), С. 376 - 376

Опубликована: Май 1, 2020

The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation individual antioxidants separately. Therefore, this is first study assess antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. involved 60 with Class 3 obesity (BMI > 40 kg/m2) divided into two equal subgroups: without and metabolic syndrome. analyses were performed plasma samples collected before surgery as well 1, 3, 6, 12 months after laparoscopic sleeve gastrectomy. Total capacity (TAC), ferric-reducing power (FRAP), DPPH (2,2'-diphenyl-1-picrylhydrazyl) radical assay, oxidant (TOS) significantly (as compared healthy controls, n = 60) generally decreased treatment. Interestingly, all assessed biomarkers correlated positively uric acid content. However, potential did not differ between syndrome those both Only differentiated subgroups (p < 0.0001; AUC 0.8) 73% sensitivity 77% specificity. Plasma TAC body mass index, waist-hip ratio, serum insulin, acid. be best biomarker patients.

Язык: Английский

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TPGS assists the percutaneous administration of curcumin and glycyrrhetinic acid coloaded functionalized ethosomes for the synergistic treatment of psoriasis

International Journal of Pharmaceutics, Год журнала: 2021, Номер 604, С. 120762 - 120762

Опубликована: Май 31, 2021

Язык: Английский

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