Cellular Signalling,
Год журнала:
2023,
Номер
109, С. 110794 - 110794
Опубликована: Июль 6, 2023
Traditionally,
mitochondria
are
known
as
"the
powerhouse
of
the
cell,"
responsible
for
energy
(ATP)
generation
(by
electron
transport
chain,
oxidative
phosphorylation,
tricarboxylic
acid
cycle,
and
fatty
ß-oxidation),
regulation
several
metabolic
processes,
including
redox
homeostasis,
calcium
signalling,
cellular
apoptosis.
The
extensive
studies
conducted
in
last
decades
portray
multifaceted
signalling
organelles
that
ultimately
command
cells'
survival
or
death.
Based
on
current
knowledge,
we'll
outline
mitochondrial
to
other
intracellular
compartments
homeostasis
pathology-related
stress
conditions
here.
following
topics
discussed:
(i)
mtROS
mitohormesis,
(ii)
Ca2+
signalling;
(iii)
anterograde
(nucleus-to-mitochondria)
retrograde
(mitochondria-to-nucleus)
signal
transduction,
(iv)
mtDNA
role
immunity
inflammation,
(v)
induction
mitophagy-
apoptosis
-
cascades,
(vi)
dysfunctions
(mitochondriopathies)
cardiovascular,
neurodegenerative,
malignant
diseases.
novel
insights
into
molecular
mechanisms
mitochondria-mediated
can
explain
adaptation
environmental
stresses
achieve
cell
survival.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 23
Опубликована: Окт. 19, 2022
Reactive
oxygen
species
(ROS)
are
bioproducts
of
cellular
metabolism.
There
is
a
range
molecules
with
oxidizing
properties
known
as
ROS.
Despite
those
being
implied
negatively
in
aging
and
numerous
diseases,
their
key
role
signaling
evident.
ROS
control
several
biological
processes
such
inflammation,
proliferation,
cell
death.
The
redox
underlying
these
events
one
characteristic
the
new
generation
scientists
aimed
at
defining
environment.
potential,
which
includes
balance
sources
antioxidant
system,
implies
an
important
target
for
understanding
cells’
fate
derived
from
signaling.
In
this
review,
we
summarized
chemical,
balance,
signaling,
implications
aging.
Experimental & Molecular Medicine,
Год журнала:
2022,
Номер
54(8), С. 1067 - 1075
Опубликована: Авг. 17, 2022
Intervertebral
disc
degeneration
(IDD)
is
a
common
degenerative
musculoskeletal
disorder
and
recognized
as
major
contributor
to
discogenic
lower
back
pain.
However,
the
molecular
mechanisms
underlying
IDD
remain
unclear,
therapeutic
strategies
for
are
currently
limited.
Oxidative
stress
plays
pivotal
roles
in
pathogenesis
progression
of
many
age-related
diseases
humans,
including
IDD.
Nuclear
factor
E2-related
2
(Nrf2)
master
antioxidant
transcription
that
protects
cells
against
oxidative
damage.
Nrf2
negatively
modulated
by
Kelch-like
ECH-associated
protein
1
(Keap1)
exerts
important
effects
on
progression.
Accumulating
evidence
has
revealed
can
facilitate
downstream
genes
binding
response
elements
(AREs)
promoter
regions,
heme
oxygenase-1
(HO-1),
glutathione
(GSH),
superoxide
dismutase
(SOD),
catalase
(CAT),
NADPH
quinone
dehydrogenase
(NQO1).
The
defense
system
regulates
cell
apoptosis,
senescence,
extracellular
matrix
(ECM)
metabolism,
inflammatory
nucleus
pulposus
(NP),
calcification
cartilaginous
endplates
(EP)
In
this
review,
we
aim
discuss
current
knowledge
systematically.
Antioxidants,
Год журнала:
2022,
Номер
11(7), С. 1224 - 1224
Опубликована: Июнь 22, 2022
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest
occurring
in
response
to
stressful
stimuli,
such
as
telomere
attrition,
DNA
damage,
reactive
oxygen
species,
and
oncogenic
proteins.
Although
beneficial
protective
several
physiological
processes,
excessive
senescent
burden
has
been
involved
various
pathological
conditions
including
aging,
tissue
dysfunction
chronic
diseases.
Oxidative
stress
(OS)
can
drive
due
a
loss
balance
between
pro-oxidant
stimuli
antioxidant
defences.
Therefore,
the
identification
characterization
compounds
capable
preventing
or
counteracting
phenotype
major
interest.
However,
despite
considerable
number
studies,
comprehensive
overview
main
molecules
OS-induced
still
lacking.
Here,
besides
brief
description
molecular
mechanisms
implicated
OS-mediated
we
review
discuss
role
enzymes,
mitochondria-targeting
compounds,
vitamins,
carotenoids,
organosulfur
nitrogen
non-protein
molecules,
minerals,
flavonoids,
non-flavonoids
with
anti-aging
potential,
therefore
offering
insights
into
innovative
lifespan-extending
approaches.
Marine Drugs,
Год журнала:
2023,
Номер
21(2), С. 105 - 105
Опубликована: Фев. 1, 2023
The
aim
of
this
study
was
to
investigate
the
protective
function
and
mechanism
TCP3
(PKK),
TCP6
(YEGGD)
TCP9
(GPGLM)
from
skipjack
tuna
cardiac
arterial
bulbs
on
skin
photoaging
using
UVB-irradiated
HaCaT
cell
model.
present
results
indicated
that
had
significant
cytoprotective
effect
cells
(p
<
0.001).
Hoechst
33342
staining
showed
apoptosis
UV-irradiated
could
be
significantly
reduced
by
treatment
(GPGLM);
JC-1
protect
restoring
mitochondrial
membrane
potential
(MMP);
Furthermore,
down-regulate
ratio
Bax/Bcl-2
reduce
expression
level
apoptosis-executing
protein
Caspase-3
decreasing
Caspase-8
Caspase-9
0.05).
action
up-regulate
levels
Nrf2,
NQO1
HO-1
0.05),
which
further
increased
activity
downstream
proteases
(SOD,
CAT
GSH-Px),
scavenged
reactive
oxygen
species
(ROS)
decreased
intracellular
malondialdehyde
(MDA).
In
addition,
molecular
docking
(PKK)
competitively
inhibit
Nrf2
binding
site
because
they
can
occupy
connection
Kelch
domain
Keap1
protein.
inferred
non-competitive
inhibition
it
not
bind
active
summary,
antioxidant
peptides
effectively
damage
used
in
development
healthy
cosmetic
products
treat
diseases
caused
UV
radiation.
Cardiovascular Therapeutics,
Год журнала:
2022,
Номер
2022, С. 1 - 11
Опубликована: Июль 15, 2022
Diabetes
causes
lipid
peroxide
to
accumulate
within
cardiomyocytes.
Furthermore,
buildup
is
a
risk
factor
for
ferroptosis.
This
study
aimed
at
examining
whether
curcumin
can
ameliorate
ferroptosis
in
the
treatment
of
diabetic
cardiomyopathy.
Hematoxylin
and
eosin
Masson
sections
were
used
examine
morphology,
arrangement,
degree
fibrosis
myocardium
rabbit
models.
The
expression
levels
nuclear
Nrf2,
Gpx4,
Cox1,
Acsl4
animal
cell
models
quantitatively
analyzed
using
immunofluorescence
western
blotting.
Nrf2-overexpression
lentivirus
vectors
transfected
into
cardiomyocytes,
protective
effects
Nrf2
on
cardiomyocytes
under
high
glucose
stimulation
assessed
terminal
deoxynucleotidyl
transferase
dUTP
nick-end
labelling
reactive
oxygen
species
probes.
was
found
disorder
myocardial
arrangement
significantly
increase
collagen
cells.
Curcumin
transfer
Gpx4
HO-1,
reduce
induced
damage,
reverse
damage
caused
by
inducer
erastin.
confirmed
that
promote
translocation
oxidative
scavenging
factors,
such
as
excessive
loss,
inhibit
glucose-induced
highlights
potentially
new
therapeutic
route
investigation
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15743 - 15743
Опубликована: Дек. 12, 2022
Diabetes
is
considered
a
new
pandemic
of
the
modern
world,
and
number
sufferers
steadily
increasing.
Sustained
hyperglycemia
promotes
production
free
radicals
leads
to
persistent,
low-grade
inflammation.
Oxidative
stress
causes
mitochondrial
destruction,
which
along
with
activation
hexosamine
pathway,
nuclear
factor-κB
(Nf-κb),
p38
mitogen-activated
protein
kinase
(p38
MAPK),
c-jun
NH2
terminal
kinase/stress-activated
(JNK/SAPK)
or
toll-like
receptors
(TLRs),
pancreatic
β-cell
dysfunction.
However,
there
also
protective
mechanism
that
counteracts
oxidative
inflammation
in
diabetes,
mitophagy,
autophagy.
An
important
part
strategy
control
diabetes
lead
healthy
lifestyle
based
on,
among
other
things,
regular
physical
activity,
giving
up
smoking,
eating
balanced
diet
containing
ingredients
antioxidant
potential,
including
vegetables
fruits,
using
hypoglycemic
pharmacotherapy.
Tobacco
smoke
recognized
modifiable
risk
factor
for
many
diseases
it
has
been
shown
disease
increases
proportion
intensity
smoking.
Physical
activity
as
another
component
therapy
can
effectively
reduce
glucose
fluctuations,
high
interval
exercise
appears
have
most
beneficial
effect.
A
proper
not
only
cellular
sensitivity
insulin,
but
able
stress.
Pharmacotherapy
affect
Some
oral
drugs,
such
metformin,
pioglitazone,
vildagliptin,
liraglutide,
exenatide,
cause
reduction
markers
and/or
inflammation,
while
drug
Imeglimin
reverses
In
studies
sitagliptin,
vildagliptin
effects
on
were
achieved
by,
reducing
glycemic
excursions.
For
insulin
therapy,
no
corresponding
correlation
was
observed.
Insulin
did
parameters.
There
between
variability
patients
therapy.
The
data
used
this
study
obtained
by
searching
PubMed
online
databases,
taking
into
account
recent
studies.
