Efficacy and safety of acupuncture treatment for fatigue after COVID-19 infection: study protocol for a pilot randomized sham-controlled trial DOI Creative Commons
Sung-A Kim, Jisu Lee, Tae-Gon Kim

и другие.

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 15, 2023

Background As the coronavirus disease 2019 (COVID-19) pandemic has spread globally, its sequelae, called Long COVID, have persisted, troubling patients worldwide. Although fatigue is known to be most frequent among COVID symptoms, mechanism and treatment not been clearly demonstrated. In 2022, we conducted a preliminary prospective case series found that acupuncture moxibustion were feasible interventions for fatigue. This study pilot patient-assessor-blinded randomized sham-controlled trial evaluate efficacy safety of with persisted at least 4 weeks after recovery from COVID-19. Methods Thirty will recruited randomly assigned either or sham groups. Treatment thrice week both groups during weeks. The primary outcome acupuncture, including numeric rating scale (NRS), brief inventory (BFI), severity (FSS), adverse event evaluation. Secondary outcomes evaluation improvement in comorbid symptoms feasibility variables. Outcome variables assessed before treatment, 8 completion. Discussion results this used clarify persistent COVID. Additionally, design was validated provide evidence future full-scale controlled trials. Clinical registration : identifier: KCT0008656 https://cris.nih.go.kr/cris/search/detailSearch.do?seq=24785&search_page=L .

Язык: Английский

Long COVID Research, 2020–2024: A PubMed-Based Bibliometric Analysis DOI Open Access
Cristina Honorato‐Cia, Elena Cacho‐Asenjo, Antonio Martínez-Simón

и другие.

Healthcare, Год журнала: 2025, Номер 13(3), С. 298 - 298

Опубликована: Фев. 1, 2025

Long COVID is a SARS-CoV-2 infection-associated chronic condition with great potential to impact health and socioeconomic outcomes. The research efforts face the challenges related long have resulted in substantial amount of publications, which warrants need for bibliometric profiling. This large-scale PubMed-based analysis more than 390,000 COVID-19 publications. overall aim was update profile publications comparison rest scientific literature through December 2024. estimated proportion relatively low (2.3% all publications), although cumulative frequency (n = 8928) continues pose challenge proper information management. Currently, “treatment” “mechanism” appear be most predominant topics literature. Interestingly, this evaluation revealed distinctive literature, clear preponderance “case report” when compared other also identified ranked prolific journals production COVID-related study may improve visibility contribute management growing knowledge on COVID.

Язык: Английский

Процитировано

1
A single-cell RNA sequencing dataset of peripheral blood cells in long COVID patients on herbal therapy DOI Creative Commons
Karolina Hanna Prazanowska, Tae-Hun Kim, Jung Won Kang

и другие.

Scientific Data, Год журнала: 2025, Номер 12(1)

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
Patient-Related Metadata Reported in Sequencing Studies of SARS-CoV-2: Protocol for a Scoping Review and Bibliometric Analysis DOI Creative Commons
Karen O’Connor, Davy Weissenbacher, Amir Elyaderani

и другие.

JMIR Research Protocols, Год журнала: 2025, Номер 14, С. e58567 - e58567

Опубликована: Апрель 22, 2025

Background There has been an unprecedented effort to sequence the SARS-CoV-2 virus and examine its molecular evolution. This facilitated by availability of publicly accessible databases, such as GISAID (Global Initiative on Sharing All Influenza Data) GenBank, which collectively hold millions records. Genomic epidemiology, however, seeks go beyond phylogenetic (the study evolutionary relationships among biological entities) analysis linking genetic information patient characteristics disease outcomes, enabling a comprehensive understanding transmission dynamics impact. While these repositories include fields reflecting patient-related metadata for given sequence, inclusion demographic clinical details is scarce. The current in published sequencing studies quality remains unexplored. Objective Our review aims quantitatively assess extent patient-reported papers reporting original whole genome analyze publication patterns using bibliometric analysis. Finally, we will evaluate efficacy reliability machine learning classifier accurately identifying relevant scoping review. Methods National Institutes Health’s LitCovid collection be used automated classification having deposited sequences public repositories, while independent search conducted MEDLINE PubMed Central validation. Data extraction Covidence (Veritas Health Innovation Ltd). extracted data synthesized summarized quantify literature studies. For analysis, points, author affiliations, citation metrics, keywords, Medical Subject Headings terms extracted. Results expected completed early 2025. model developed have classified publications through February 2023. As September 2024, August 2024 are being prepared processing. Screening underway validated from classifier. Direct searches screening results began October 2024. We summarize narratively describe our findings tables, graphs, charts where applicable. Conclusions report types reported genomic viral SARS-CoV-2, identify gaps metadata, make recommendations improving consistency this area. uncover trends including differences based or geographic regions. insights gained may help improve enhancing utility facilitating future research infectious diseases. Trial Registration OSF Registries osf.io/wrh95; https://doi.org/10.17605/OSF.IO/WRH95 International Registered Report Identifier (IRRID) DERR1-10.2196/58567

Язык: Английский

Процитировано

0
Visual analysis of hotspots and trends in long COVID research based on bibliometric DOI Creative Commons
Zongqiang Lai,

Tao Pu,

Jun Li

и другие.

Heliyon, Год журнала: 2024, Номер 10(2), С. e24053 - e24053

Опубликована: Янв. 1, 2024

After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a series of symptoms may persist for long time, which is now called COVID. It was found that COVID can affect all patients with COVID-19. Therefore, has become hot topic. In this study, we used the WOS database as sample data source to conduct bibliometric and visual analysis 1765 articles over past three years through VOSviewer R package. The results show countries/authors in Europe United States America contribute most articles, their cooperation also active. Keyword co-occurrence identified four clusters, important topics including mechanism, clinical symptoms, epidemiological characteristics, management/treatment Themes such "cognitive impairment", "endothelial dysfunction", "diagnosis", "biomarkers" are likely be focus new attention coming period. addition, put forward possible research opportunities on researchers practitioners facilitate future research.

Язык: Английский

Процитировано

3
Herbal Medicines for Long COVID: A Phase 2 Pilot Clinical Study DOI Creative Commons
Tae-Hun Kim, Jiwon Yoon, Sang‐Hyun Kim

и другие.

Heliyon, Год журнала: 2024, Номер 10(18), С. e37920 - e37920

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

3
The effect of Nigella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial DOI Creative Commons

Shimaa A. Said,

Alsayyed Abdulbaset,

Amal A. El-Kholy

и другие.

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 8, 2022

Background: The coronavirus disease 2019 (COVID-19) is a novel that causes severe infection in the respiratory system. Since immune status plays an essential role combating COVID-19, herbal medicines, which have immunomodulatory effect, may help prevent and even treat COVID-19. Nigella sativa one of medicines with antiviral activities, its therapeutic effectiveness makes it promising add-on therapy for In addition, vitamin D3 has role, but effect supplementation SARS-CoV-2 still not well-known. Objective: This study aims to investigate effects as single supplemental therapies combination on viral clearance indicated by negative polymerase chain reaction alleviation symptoms during follow-up duration 14 days. Patients Methods: design was open-label randomized controlled clinical trial conducted at Respiratory Hospital Kobry El Qobba Armed Forces Medical Complex. total, 120 COVID-19 patients mild moderate were randomly assigned four groups, thirty each, follows: Group 1 received oral dose 900 mg through 450 soft gelatin capsules twice daily two weeks; 2 2,000 IU 1000-IU tablets given tablets, once daily; 3 same manner dosing previous groups; 4 control group. All groups standard infections management COVID-19’s symptoms. Results: –vitamin addition significantly contributed most symptoms: 50% free cough after 7 days, 70% showed absence fatigue 80% had no headache 5 90% rhinorrhea 86.7% dyspnea Moreover, studied reduced median temperature days treatment. Negative results (PCR) test recorded 7th 14th day superior arm compared those other arms where value odds ratio (OR) 0.13 95% CI: 0.03–0.45 0.09 0.02–0.3. Conclusion: this benefit administration Additionally, remarkable short time interval reduction severity progression recommended use patients. Clinical Trial Registration: ClinicalTrials.gov , Identifier: NCT04981743.

Язык: Английский

Процитировано

15
Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside DOI

Jhong Yuan Chen,

Tsung Rung Huang,

Shih Yun Hsu

и другие.

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 2597 - 2618

Опубликована: Март 13, 2024

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the global disease 2019 (COVID‐19) pandemic since 2019. Immunopathogenesis and thromboembolic events are central to its pathogenesis. Quercetin exhibits several beneficial activities against COVID‐19, including antiviral, anti‐inflammatory, immunomodulatory, antioxidative, antithrombotic effects. Although reviews have been published, these incomplete from viewpoint of translational medicine. The authors comprehensively evaluated evidence quercetin both basically clinically, apply and/or derivatives in future. searched PubMed, Embase, Cochrane Library databases without any restrictions. search terms included SARS‐CoV‐2, quercetin, thrombosis, embolism, oxidative, microbiota. references relevant articles were also reviewed. All independently screened reviewed quality each manuscript. Risk Bias Tool, version (RoB 2) was used assess randomized controlled trials (RCTs). selected studies discussed monthly. effectiveness COVID‐19 is not solid due methodological flaws clinical trials. High‐quality required for quercetin‐containing traditional Chinese medicines. low bioavailability highly variable pharmacokinetics hinder applications. Its positive impact on immunomodulation through reverting dysbiosis gut microbiota still lacks robust evidence. does tough Strategies improve develop effective needed. Well‐designed RCTs crucial confirm their

Язык: Английский

Процитировано

2
Complementary and alternative medicine for long COVID: a systematic review of randomized controlled trials DOI Creative Commons
Juan Yang, Kia Hui Lim,

Kia Teng Lim

и другие.

Therapeutic Advances in Chronic Disease, Год журнала: 2023, Номер 14

Опубликована: Янв. 1, 2023

Complementary and alternative medicine (CAM) interventions are growing in popularity as possible treatments for long COVID symptoms. However, comprehensive analysis of current evidence this setting is still lacking.

Язык: Английский

Процитировано

4
Herbal Medicines for Long COVID: A Phase 2 Pilot Clinical Study DOI Open Access
Tae-Hun Kim, Ji‐Won Yoon, Sang‐Hyun Kim

и другие.

Опубликована: Янв. 23, 2024

Background: Infections of Coronavirus Disease-2019 (COVID-19) can cause long-term effects known as long COVID. This pilot study aimed to evaluate the feasibility a clinical well efficacy and safety traditional East Asian herbal medicines in alleviating fatigue cognitive dysfunction “brain fog” patients with Methods: prospective investigated use three types medicines, Bojungikki-tang (BIT), Kyungok-go (KOG), Cheonwangbosim-dan (CBD), for 12-week period potential treatments Forty-five COVID were recruited, one drugs was given based on patient’s symptoms pattern identification. The effect medications function outcomes assessed over 36-week period, patient adherence closely monitored. Results: After 12 weeks drug administration, improved significantly across all groups, treatment success rates 80%, 53.33%, 46.67% BIT, KOG, CBD respectively. However, showed less improvement, 40%, 46.67%, 13.33% All adverse events reported mild unrelated medication. design found be feasible high medication adherence. Conclusions: demonstrated conducting trial treat like fog.”

Язык: Английский

Процитировано

1
Scoping review e análise bibliométrica da produção científica sobre o estudo de coleções especiais: uma visão panorâmica do Google Scholar, Dimensions Free e Academia.edu DOI Open Access
Yelina Piedra Salomón, Carlos Manuel Valenciaga Díaz, Zoia Rivera

и другие.

Encontros Bibli Revista Eletrônica de Biblioteconomia e Ciência da Informação, Год журнала: 2024, Номер 29

Опубликована: Июль 18, 2024

Objetivos: Sistematizar la literatura científica sobre el estudio de las colecciones documentos especiales disponibles en fuentes datos acceso abierto. Métodos: Se utiliza scoping review como herramienta metodológica. aplica framework SALSA y plantilla PRISMA- ScR. La revisión sistemática exploratoria Google Scholar, Dimensions Academia. Edu se complementa con un bibliométrico. conjunción ambas tributa a abordaje más holístico del objeto estudio. Resultados: análisis bibliométrico permitieron identificar características y/o rasgos distintivos dominio cuestión partir contenido científica. obtuvo una diversidad terminológica (homonimia, sinonimia, polisemia) existente torno denominación mismo documento/colección. El mapeo cobertura perfil temático determinó existencia amplia configuración temática génesis propuestas para dichas asociado frente que favorece aplicación Humanidades Digitales. Conclusiones: visualización los elementos, obtenidos revisión, revela evolución ascenso metodologías -desde CI - persiguen creación alternativas decodificación conforman utilizando nueva perspectiva ofrece bondades mayor inclusividad, homogeneidad responsabilidad social.

Процитировано

1