Asian Journal of Surgery, Год журнала: 2023, Номер 47(3), С. 1585 - 1586
Опубликована: Дек. 15, 2023
Язык: Английский
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(1), С. 267 - 267
Опубликована: Янв. 3, 2024
Background: Intraoral adenoid cystic carcinoma (ACC) arising from minor salivary glands (MSG) is a rare malignancy associated with delayed diagnosis and unfavorable outcomes. This study aimed to comprehensively review ACC of MSGs, focusing on clinical characteristics, imaging modalities, treatment approaches, long-term Methods: A systematic search was conducted in PubMed, Web Science, MEDLINE databases identify relevant articles reporting cases MSGs between January 1997 March 2023. The registered PROSPERO (ID: CRD42023449478). total 10 studies that met the inclusion criteria were selected for critical review. In total, 902 patients diagnosed an age range 44.3 63 years, average 56.6 years. female male ratio ranges 1:1 2.4:1. Regarding primary site ACC, palate most common location, accounting 30.5% 83.3%, followed by buccal mucosa, floor mouth, lip retromolar area. For histology, solid mass pattern prevalent, seen 95.2% patients, cribriform pattern. surgery approach, applied 76.3% cases, combination radiotherapy used 29.0% cases. smaller fraction, 3.2%, received surgery, chemotherapy, radiotherapy, 8.3% underwent alone. Local recurrence rates varied 1% 28.5%, distant metastasis occurred 18.2% 33.3% predominantly lymph nodes (14.5%). An analysis overall survival across various stages patient numbers indicated 5-year rate 68.0%. findings this provide valuable insights physicians making decisions emphasize need ongoing research collaborative efforts improve management outcomes challenging disease. Conclusion: multifaceted condition typically manifesting as asymptomatic enlargement ulceration. disease marked distinct histopathological patterns perineural invasion (PNI). Recognizing these distinctive aspects key shaping plan, which can surgical procedures radiation therapy, evolving targeted treatments. Continuous remain progress condition.
Язык: Английский
Процитировано
13
Oncology Letters, Год журнала: 2025, Номер 29(3)
Опубликована: Янв. 22, 2025
Adenoid cystic carcinoma (ACC) of the salivary glands is second most common type gland cancer, and characterized by a poor prognosis an unclear pathology. The incidence ACC rare, as it accounts for 10-15% all tumors affects mainly patients aged between 50 60 years. annual rate estimated to be ~4.5 cases per 100,000 individuals. Due its rarity use contaminated cell lines in previous investigations, precise etiological factors underlying remain poorly understood. Current treatment modalities, typically involving surgery with or without postoperative radiotherapy, often prove unsatisfactory due potential local recurrence delayed distant metastases, which may manifest 3-5 years after constitute primary failure existing therapeutic approaches. indolent growth pattern, along perineural perivascular invasion, potentially responsible onset metastases. No effective systemic therapy has been established so far. Therefore, management represents significant challenge. Exploring molecular characteristics ACC, including reasons behind propensity invasion correlation immune system, offers promising strategies managing could open up novel pathways future interventions. Currently, immunotherapy shown limited effectiveness. While exact mechanism lack response remains unknown, low levels tumor-infiltrating lymphocytes these contribute this resistance. identifying targets enhance against tumor cells essential. present review provides update on clinical studies explores that ACC.
Язык: Английский
Процитировано
1
British Journal of Cancer, Год журнала: 2025, Номер unknown
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
1
Pediatric Blood & Cancer, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Pediatric salivary gland malignancies (SGM) present challenges in managing cervical nodes. We aimed to characterize lymph node invasion inform decisions regarding the need of systematic wide dissection (WLND). International retrospective study, conducted across seven large French and American pediatric centers, including patients (0-18 years) diagnosed with SGM from 2000 2020. Among 82 (median age 13 years), parotid was frequently affected (60 cases). Histotypes comprised mucoepidermoid (mucoepidermoid carcinoma [MEC], 43 cases), acinic cells (acinic [AcCC], 22 adenoid cystic (adenoid [AdCC], 8 (MASC, 6 adenocarcinoma (3 Primary treatments were surgery (82 cases) radiotherapy (20 cases; median dosage 64 gray). Cervical nodes therapy included WLND (≥2 levels, 29 limited resection (LNR; one level, and/or irradiation (4 54 gray; range 52.0-63.0). At diagnosis, six had (CNI) managed LNR (four (two (three After a follow-up years (range 1-22), nine tumor event: local relapse/progression or combined Of CNI, at diagnosis relapse, four MASC. Five-year event-free overall survival (OS) rates were, respectively, 90.1% 98.8%. CNI is rare but noted 11% cases, higher incidence Overall, outcome good tailored locoregional multidisciplinary approach. Systematic should be reconsidered. This international multi-institutional study analyzed clinical presentation pattern relapse newly malignancies. nodal only 7%. In addition, 6% developed during follow-up. Incidence spread frequent mammary analogue secretory (MASC). The promising reconsidered tumors.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Adenoid cystic carcinoma (ACC) is a relatively uncommon tumor among head and neck cancers, with laryngeal involvement, typically subglottic, being exceptionally rare. While ACC usually originates in the salivary glands, its occurrence larynx highly unusual. Laryngeal adenoid (LACC) characterized by indolent growth, frequent perineural invasion, tendency for local recurrence. Moreover, distant metastasis can occur lungs most common site of metastasis. We present case 28-year-old male patient progressively enlarging right mass, uncovering rare infiltrative LACC invading thyroid gland. Post thyroidectomy, 18-fluoro-2-deoxyglucose (F-18-FDG)-positron emission tomography (PET)/computed (CT) scan revealed FDG-avid posterior subglottic residual disease invasion into adjacent structures, including trachea. This represents one few documented cases LACC, contributing to sparse literature on this aggressive malignancy. highlights diagnostic challenge clinical significance FDG-PET/CT evaluating malignancies like LACC.
Язык: Английский
Процитировано
0
Head & Neck, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a slow‐growing tumor with variable outcomes, making follow‐up protocols challenging. This review analyzed outcomes in ACC, focusing on patterns and factors related to adverse prognoses. Methods A search was conducted March 25, 2024, MEDLINE, PubMed, Scopus, EMBASE. Studies analyzing ACC survival were included, while those lacking these data or single site excluded. The Joanna Briggs Institute's Critical Appraisal tool used assess the risk of bias, metanalysis performed using R software. Results Among 57 studies (17 497 patients), predominantly affected women (mean age: 52.69 years) occurred mainly minor salivary glands. Distant metastasis most frequent outcome, occurring at 34.8 months average. Locoregional local recurrence 27.5 31.3 months, respectively. Five‐, 10‐, 15‐, 20‐year rates 73.8%, 48.5%, 42.3%, 26.5%, Poor predictors included advanced T stage, positive lymph nodes, solid tumors, distant metastasis, surgical margins. Conclusions outcome prognostic are residual tumors.
Язык: Английский
Процитировано
0
Journal of Neuro-Oncology, Год журнала: 2024, Номер 166(2), С. 369 - 376
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2
Dentistry Journal, Год журнала: 2023, Номер 11(11), С. 262 - 262
Опубликована: Ноя. 9, 2023
Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor that accounts for approximately 1% of all head and neck cancers. Despite its initial indolent behavior, long-term survival poor due to locoregional recurrence in 40% distant metastasis up 60% patients who undergo radical treatment. The histological parameters ACC the combination these histopathological grading systems provide valuable prognostic information about clinical course disease. Within this context, review aims analyze impact parameters, individual or combined malignancy, on prognosis. Individual such as solid pattern, presence necrosis, high-grade transformation, dominance epithelial component, perineural lymphovascular invasion, positive surgical margins have negative impacts with ACC. There are currently four ACC; however, few studies validated most them explored small cohorts short follow-up. Considering application has been associated prognosis, broader validation will allow not only their use prediction but also assist treatment planning.
Язык: Английский
Процитировано
5
EJC Paediatric Oncology, Год журнала: 2023, Номер 2, С. 100129 - 100129
Опубликована: Ноя. 22, 2023
BackgroundSalivary gland carcinomas (SGCs) are exceedingly rare in children, with a reported annual incidence of 0.8-1.4/1,000,000 under 20 years age. Evidence regarding optimal treatment pediatric SGCs is limited, and for long time, no guidelines have been available. Here, we report on an international retrospective series children adolescents collected by several national tumor study groups cooperating the European Cooperative Study Group Pediatric Rare Tumors (EXPeRT)Patients MethodsPatients diagnosed between 2000 2014 were included Data reviewed respective working harmonized data sheet to EXPeRT central analysis.ResultsOverall, 121 patients identified, including 103 parotid tumors, 12 submandibular tumors six minor glands. In 11 patients, secondary cancers. Mucoepidermoid carcinoma was most frequent diagnosis (n=65), followed acinic cell (n=39), adenocystic (n=7), sialoblastoma (n=3) other (n=7). All underwent resection (R0: 66%, R1: 34%). Neck dissection performed 47 revealing nodal metastases 13. Twenty-four irradiation, received adjuvant chemotherapy. During median follow-up 25 (6-140 months), 14 relapses observed (7 local, 5 2 distant metastases). Five died disease. Higher histological grade associated advanced local stage risk recurrence.ConclusionsSGCs mostly present as localized low malignant potential. approximately 10% regional lymph node at diagnosis. After complete resection, prognosis favorable. Surgery mainstay treatment; or cervical irradiation should be reserved those less favorable biology such carcinoma.
Язык: Английский
Процитировано
4
Current Pharmaceutical Design, Год журнала: 2024, Номер 30(29), С. 2276 - 2289
Опубликована: Июнь 24, 2024
Background: Salivary Adenoid Cystic Carcinoma (ACC) is characterized by a highly invasive and slow-growing pattern, its etiology remains unidentified. Triptonide (TN) has demonstrated efficacy as pharmacotherapeutic agent against ACC. Nonetheless, the specific targets mechanism of molecular action underlying effectiveness TN in treating ACC have not been elucidated. Objectives: By integrating network pharmacology within laboratory experiments, this research delves into prospective mechanisms associated with application Methods: Initially, pertinent were acquired from public databases. Subsequently, combination bioinformatics analysis was utilized to screen top 10 hub key signal pathways TN-treating Finally, vitro experiments involving various assays conducted evaluate biological phenotypes cells following treatment, encompassing assessments apoptosis levels, plate migration, other parameters, thereby validating pivotal genes pathways. Results: A total 23 for relation identified, being MAPK8, PTGS2, RELA, MAPK14, NR3C1, HDAC1, PPARG, NFKBIA, AR, PGR. There significant correlation between TNF signaling pathway treatment TN. In that elevated RELA phosphorylation while concurrently reducing MAPK14 inducing G2/M arrest. exhibited ability enhance rate through increased caspase-3 activity, levels Reactive Oxygen Species (ROS), mitochondrial dysfunction, inhibition cell migration. Conclusion: potential therapeutic role activation pathway. Among identified candidates, PGR emerge most context treatment.
Язык: Английский
Процитировано
1