Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Фев. 7, 2024
Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish work to be cited a reference. Questions should directed corresponding author.
Язык: Английский
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 901 - 901
Опубликована: Июль 5, 2024
This study aims to develop innovative heterocyclic nanocomposites incorporating silver nanoparticles (SNPs) for potential therapeutic applications targeting infections, gastric ulceration, inflammation, and oxidative damage. By synthesizing new derivatives of spiro-thiazolidine-carbonitrile (Py-ST-X) them into Ag (AgNPs) carbon nanotubes (CNTs), we have prepared Ag@Py-ST-X Ag@Py-ST-X@CNT nanocomposites, respectively. The physical properties these materials were studied using XRD, TEM, SEM, Zeta techniques. In our investigation involving rats with ulcers, observed noteworthy inhibitory effects on acid enzyme activity, specifically H+/K+ATPase, by Ag@Py-ST-NO2 Ag@Py-ST-Br demonstrating reductions 25 34%, respectively, compared untreated ulcers. Nanotubulation compounds further improved their efficacy 29 45%, Additionally, showed the most potent myeloperoxidase (MPO)-inhibitory 36 49% inhibition, nanotubulated versions reaching 44 53%. Moreover, Ag@Py-ST-NO2@CNT Ag@Py-ST-Br@CNT significant antioxidant reducing thiobarbituric reactive substances (TBARS) 35 51%, hydrogen peroxide (H2O2) levels 49 71%, These confirmed in surface area (GSA) 44% 52%, a decrease ulcer index (UI) from 80% 38%, an increase curative (CI) 19 55 62% following administration Ag@Py-ST-Br@CNT, Histological studies support findings, suggesting as promising candidates treating various disorders.
Язык: Английский
Процитировано
1
Food Chemistry, Год журнала: 2024, Номер 464, С. 141612 - 141612
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
1
Journal of Chemistry and Nutritional Biochemistry, Год журнала: 2023, Номер 4(2), С. 51 - 77
Опубликована: Дек. 31, 2023
Betanin, a prominent compound found in beetroot, however, the potential protective effects of this against gastric damage and ulceration have yet to be explored. This study aims investigate impact purified beetroot betanin (Bet) on activities inflammatory enzymes gene expressions associated with inflammation tissues. Gastric ulcer rats were induced by ethanol at dose 5ml/kg body weight. Ulcerated treated or omeprazole; from which some inflammation-related genes gastric-inflammation investigated using RT-PCR biochemical analysis, respectively. Bet effectively suppressed key involved mucosal inflammation, including 5-Lipoxygenase (5-LO), Hyaluronidase (HAase), myeloperoxidase (MPO), 58%, 50%, 45%, Docking studies showed binding catalytic sites regions for enzymes’ activities, thus explaining inhibitory capacity. ingestion decreased expression levels genes, factor-kappa B (NF-ϰB) 57%. down-regulation subsequently led reduction inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumour necrosis factor-α (TNF-α). supressed thiobarbituric acid reactive substance (TBARS) rates 59%, augmented (NO) level 107% protected tissues ulceration. revealed gastro-protective as confirmed surface area acidity 75.9% 40%, respectively, significant increase weight mucus curative index 117% 74.5%, In conclusion, these outcomes physiological molecular-based investigations are indicative use functional food additive prevention ulcer.
Язык: Английский
Процитировано
2
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Янв. 15, 2024
Abstract Background in recent years, it has become necessary to use natural food colorants protect against different diseases and disorders. The present study aimed purify, evaluate the stability, investigate effect of purified Spirulina C-Phycocyanin (CPC) on digestive metabolic enzymes linked hyperglycemia. Methods purification CPC was performed using column chromatography isolate compounds reversed-phase high performance liquid combined with diode array detector (DAD) ultraviolet spectroscopy (DAD-HPLC-UV) infrared Fourier transform (FTIR). Results findings this indicate that is stable at temperatures below 45°C a pH range 5 7, as well during storage 4°C. In diabetic rats, ingestion by rats suppressed key related inflammation pancreas, such 5-Lipoxygenase (5-LO), hyaluronidase (HAase), myeloperoxidase (MPO), NADPH oxidase (NOX2 activities) 48, 41, 75, 47%, respectively. Additionally, reduced pancreas thiobarbituric acid reactive substance rates (TBARS) 59%, stimulated level nitric oxide (NO) approximately 164%. Moreover, powerfully intestinal lipase, α-amylase, maltase, sucrose activities, significantly decreased glycosylated hemoglobin (HbA1c). Furthermore, glycogen phosphorylase (GP), Glycogen synthase (GS) regulated content liver rats. addition, supplementation modulated hepatic carbohydrate metabolism liver, hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase (G6P), fructose-1,6-bisphosphatase (FBP), average water intake (AFI AWI), resulting decrease blood glucose 56% compared untreated Conclusion Overall, results research showed can be used functional coloring compound prevent various pathologies ulcers, oxidative stress, diseases.
Язык: Английский
Процитировано
0
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Фев. 7, 2024
Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish work to be cited a reference. Questions should directed corresponding author.
Язык: Английский
Процитировано
0