International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(8), С. 4196 - 4196
Опубликована: Апрель 18, 2021
Thyroid
cancers
are
the
most
common
of
endocrine
system
malignancies
and
progress
must
be
made
in
areas
differential
diagnosis
treatment
to
improve
patient
management.
Advances
understanding
carcinogenic
mechanisms
have
occurred
various
fronts,
including
studies
chaperone
(CS).
Components
CS
found
quantitatively
increased
or
decreased,
some
correlations
been
established
between
quantitative
changes
tumor
type,
prognosis,
response
treatment.
These
provide
basis
for
identifying
distinctive
patterns
useful
planning
experiments
aiming
at
elucidating
role
tumorigenesis.
Here,
we
discuss
components
thyroid
(TC).
The
chaperones
belonging
families
small
heat-shock
proteins
Hsp70
Hsp90
chaperonin
Group
I,
Hsp60,
quantified
mostly
by
immunohistochemistry
Western
blot
normal
control
tissues
extracellular
vesicles.
Distinctive
differences
were
revealed
types.
frequent
finding
was
an
increase
chaperones,
which
can
attributed
augmented
need
cells
because
their
accelerated
metabolism,
growth,
division
rate.
Thus,
help
cell
rather
than
protect
patient,
exemplifying
chaperonopathies
mistake
collaborationism.
This
highlights
research
on
chaperonotherapy,
namely
development
means
eliminate/inhibit
pathogenic
chaperones.
BMC Bioinformatics,
Год журнала:
2020,
Номер
21(1)
Опубликована: Авг. 12, 2020
The
accurate
annotation
of
protein
functions
is
great
significance
in
elucidating
the
phenomena
life,
treating
disease
and
developing
new
medicines.
Various
methods
have
been
developed
to
facilitate
prediction
these
by
combining
interaction
networks
(PINs)
with
multi-omics
data.
However,
it
still
challenging
make
full
use
multiple
biological
improve
performance
annotation.We
presented
NPF
(Network
Propagation
for
Functions
prediction),
an
integrative
function
predicting
framework
assisted
network
propagation
functional
module
detection,
discovering
interacting
partners
similar
target
proteins.
leverages
knowledge
architecture
data,
such
as
domain
complex
information,
augment
protein-protein
similarity
a
manner.
We
verified
potential
accurately
inferring
functions.
According
comprehensive
evaluation
NPF,
delivered
better
than
other
competing
terms
leave-one-out
cross-validation
ten-fold
cross
validation.We
demonstrated
that
propagation,
together
can
both
discover
more
function,
unconstricted
"small-world"
feature
networks.
conclude
depends
greatly
on
whether
we
extract
exploit
proper
information
from
correlations.
Cancers,
Год журнала:
2022,
Номер
14(7), С. 1610 - 1610
Опубликована: Март 22, 2022
There
is
evidence
that
posttranslational
modifications,
including
phosphorylation,
acetylation,
methylation,
ubiquitination,
sumoylation,
glycosylation,
and
succinylation,
may
be
involved
in
thyroid
cancer.
We
review
recent
reports
supporting
a
role
of
modifications
the
tumorigenesis
cancer,
sensitivity
to
radioiodine
other
types
treatment,
identification
molecular
treatment
targets,
development
markers
become
useful
as
diagnostic
tools.
An
increased
understanding
an
important
supplement
determination
alterations
gene
expression
has
gained
increasing
prominence
years.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(8), С. 4196 - 4196
Опубликована: Апрель 18, 2021
Thyroid
cancers
are
the
most
common
of
endocrine
system
malignancies
and
progress
must
be
made
in
areas
differential
diagnosis
treatment
to
improve
patient
management.
Advances
understanding
carcinogenic
mechanisms
have
occurred
various
fronts,
including
studies
chaperone
(CS).
Components
CS
found
quantitatively
increased
or
decreased,
some
correlations
been
established
between
quantitative
changes
tumor
type,
prognosis,
response
treatment.
These
provide
basis
for
identifying
distinctive
patterns
useful
planning
experiments
aiming
at
elucidating
role
tumorigenesis.
Here,
we
discuss
components
thyroid
(TC).
The
chaperones
belonging
families
small
heat-shock
proteins
Hsp70
Hsp90
chaperonin
Group
I,
Hsp60,
quantified
mostly
by
immunohistochemistry
Western
blot
normal
control
tissues
extracellular
vesicles.
Distinctive
differences
were
revealed
types.
frequent
finding
was
an
increase
chaperones,
which
can
attributed
augmented
need
cells
because
their
accelerated
metabolism,
growth,
division
rate.
Thus,
help
cell
rather
than
protect
patient,
exemplifying
chaperonopathies
mistake
collaborationism.
This
highlights
research
on
chaperonotherapy,
namely
development
means
eliminate/inhibit
pathogenic
chaperones.
