Frontiers in Physiology,
Год журнала:
2019,
Номер
10
Опубликована: Дек. 18, 2019
Growing
elderly
populations
are
an
increasingly
serious
health
and
socio-economic
concern
for
modern
societies.
Science
has
made
tremendous
progress
in
the
understanding
of
aging
itself
which
somehow
helped
medicine
to
extend
life
expectancies.
With
increase
expectancy,
incidence
chronic
age-related
diseases
(ARDs)
also
increased.
A
new
approach
trying
solve
this
problem
is
concept
geroscience.
This
implies
that
process
common
cause
all
ARDs.
The
corollary
consequence
such
thinking
we
can
should
treat
itself.
How
move
into
medical
practice
a
big
challenge,
but
if
consider
as
disease
solved.
However,
there
no
definition
what
is,
its
causes
are,
why
it
occurs,
target(s)
interventions
be,
impossible
definitively
conclude
disease.
On
contrary,
may
be
strongly
considered
not
treated;
nonetheless,
likely
amenable
optimization
changes/adaptations
at
individual
level
achieve
better
functional
healthspan.
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
97(3), С. 977 - 1005
Опубликована: Янв. 9, 2024
High
dietary
intake
of
saturated
fatty
acids
is
a
suspected
risk
factor
for
neurodegenerative
diseases,
including
Alzheimer’s
disease
(AD).
To
decipher
the
causal
link
behind
these
associations,
high-fat
diets
(HFD)
have
been
repeatedly
investigated
in
animal
models.
Preclinical
studies
allow
full
control
over
composition,
avoiding
ethical
concerns
clinical
trials.
The
goal
present
article
to
provide
narrative
review
reports
on
HFD
models
AD.
Eligibility
criteria
included
mouse
AD
fed
defined
as
>
35%
fat/weight
and
western
containing
1%
cholesterol
or
15%
sugar.
MEDLINE
Embase
databases
were
searched
from
1946
August
2022,
32
preclinical
review.
HFD-induced
obesity
metabolic
disturbances
such
insulin
resistance
glucose
intolerance
replicated
most
studies,
but
with
methodological
variability.
Most
found
an
aggravating
effect
brain
Aβ
pathology,
whereas
tau
pathology
has
much
less
studied,
results
are
more
equivocal.
While
show
impairment
cognitive
behavior,
confounding
factors
may
blur
their
interpretation.
In
summary,
despite
conflicting
results,
exposing
rodents
highly
enriched
fat
induces
not
only
defects,
also
often
accompanied
by
aggravated
neuropathological
markers,
notably
burden.
Although
there
important
variations
between
methods,
particularly
lack
diet
characterization,
collectively
suggest
that
excessive
should
be
avoided
order
lower
incidence
Experimental & Molecular Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
In
recent
years,
the
focus
on
human
inflammation
in
research
has
increased,
with
aging-related
widely
recognized
as
a
defining
characteristic
of
aging.
Inflammation
is
strongly
correlated
mitochondrial
dysfunction.
Phosphoglycerate
mutase
family
member
5
(PGAM5)
novel
modulator
homeostasis
response
to
mechanical
stimulation.
Here
we
review
structure
and
sublocalization
PGAM5,
introduce
its
importance
programmed
cell
death
summarize
crucial
roles
development
progression
inflammatory
diseases
such
pneumonia,
hepatitis,
neuroinflammation
Notably,
PGAM5
dual
effects
controlling
inflammation:
distinct
PGAM5-mediated
functions
exhibit
cellular
heterogeneity,
leading
control.
We
therefore
highlight
double-edged
sword
nature
potential
critical
regulator
innovative
therapeutic
target
inflammation.
Finally,
challenges
future
directions
use
which
properties,
molecule
clinic
are
discussed.
This
provides
insights
guide
intelligent
strategies
targeting
PGAM5-specific
regulation
treat
intractable
conditions,
well
extension
broader
application
other
achieve
more
precise
effective
treatment
outcomes.
Cells,
Год журнала:
2020,
Номер
9(7), С. 1614 - 1614
Опубликована: Июль 4, 2020
Aging
is
characterized
by
a
chronic
low-grade
sterile
inflammation
dubbed
as
inflammaging,
which
in
part
originates
from
accumulating
cellular
debris.
These,
acting
danger
signals
with
many
intrinsic
factors
such
cytokines,
are
sensed
network
of
pattern
recognition
receptors
and
other
cognate
receptors,
leading
to
the
activation
inflammasomes.
Due
inflammasome
activity-dependent
increase
levels
pro-inflammatory
interleukins
(IL-1β,
IL-18),
initiated,
resulting
tissue
injury
various
organs,
brain
spinal
cord
included.
Similarly,
age-related
diseases
central
nervous
system
(CNS),
prominent
moment,
cells
neurovascular
unit
occupy
significant
position.
In
this
review,
we
discuss
inflammatory
changes
normal
aging
summarize
current
knowledge
on
role
inflammasomes
contributing
mechanisms
common
CNS
diseases,
namely
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis
stroke,
all
occur
more
frequently
aging.
Frontiers in Physiology,
Год журнала:
2019,
Номер
10
Опубликована: Дек. 18, 2019
Growing
elderly
populations
are
an
increasingly
serious
health
and
socio-economic
concern
for
modern
societies.
Science
has
made
tremendous
progress
in
the
understanding
of
aging
itself
which
somehow
helped
medicine
to
extend
life
expectancies.
With
increase
expectancy,
incidence
chronic
age-related
diseases
(ARDs)
also
increased.
A
new
approach
trying
solve
this
problem
is
concept
geroscience.
This
implies
that
process
common
cause
all
ARDs.
The
corollary
consequence
such
thinking
we
can
should
treat
itself.
How
move
into
medical
practice
a
big
challenge,
but
if
consider
as
disease
solved.
However,
there
no
definition
what
is,
its
causes
are,
why
it
occurs,
target(s)
interventions
be,
impossible
definitively
conclude
disease.
On
contrary,
may
be
strongly
considered
not
treated;
nonetheless,
likely
amenable
optimization
changes/adaptations
at
individual
level
achieve
better
functional
healthspan.
