Frontiers in Physiology,
Journal Year:
2019,
Volume and Issue:
10
Published: Dec. 18, 2019
Growing
elderly
populations
are
an
increasingly
serious
health
and
socio-economic
concern
for
modern
societies.
Science
has
made
tremendous
progress
in
the
understanding
of
aging
itself
which
somehow
helped
medicine
to
extend
life
expectancies.
With
increase
expectancy,
incidence
chronic
age-related
diseases
(ARDs)
also
increased.
A
new
approach
trying
solve
this
problem
is
concept
geroscience.
This
implies
that
process
common
cause
all
ARDs.
The
corollary
consequence
such
thinking
we
can
should
treat
itself.
How
move
into
medical
practice
a
big
challenge,
but
if
consider
as
disease
solved.
However,
there
no
definition
what
is,
its
causes
are,
why
it
occurs,
target(s)
interventions
be,
impossible
definitively
conclude
disease.
On
contrary,
may
be
strongly
considered
not
treated;
nonetheless,
likely
amenable
optimization
changes/adaptations
at
individual
level
achieve
better
functional
healthspan.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1774 - 1774
Published: April 5, 2023
Inflammaging
refers
to
a
chronic,
systemic,
low-grade
inflammation,
driven
by
immune
(mainly
macrophages)
and
non-immune
cells
stimulated
endogenous/self,
misplaced
or
altered
molecules,
belonging
physiological
aging.
This
age-related
inflammatory
status
is
characterized
increased
inflammation
decreased
macroautophagy/autophagy
(a
degradation
process
that
removes
unnecessary
dysfunctional
cell
components).
predisposes
diseases,
including
obesity,
type-2
diabetes,
cancer,
cardiovascular
neurodegenerative
disorders,
as
well
vulnerability
infectious
diseases
vaccine
failure,
representing
thus
major
target
for
anti-aging
strategies.
Phenolic
compounds—found
in
extra-virgin
olive
oil
(EVOO)—are
known
their
beneficial
effect
on
longevity.
Among
them,
hydroxytyrosol
(HTyr)
appears
greatly
contribute
healthy
aging
its
documented
potent
antioxidant
activity.
In
addition,
HTyr
can
modulate
autophagy,
possibly
counteracting
reducing
inflammaging.
this
review,
we
reference
the
literature
pure
modulatory
agent
of
order
highlight
possible
interference
with
HTyr-mediated
activity
might
delay
development
progression
related
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
97(3), P. 977 - 1005
Published: Jan. 9, 2024
High
dietary
intake
of
saturated
fatty
acids
is
a
suspected
risk
factor
for
neurodegenerative
diseases,
including
Alzheimer’s
disease
(AD).
To
decipher
the
causal
link
behind
these
associations,
high-fat
diets
(HFD)
have
been
repeatedly
investigated
in
animal
models.
Preclinical
studies
allow
full
control
over
composition,
avoiding
ethical
concerns
clinical
trials.
The
goal
present
article
to
provide
narrative
review
reports
on
HFD
models
AD.
Eligibility
criteria
included
mouse
AD
fed
defined
as
>
35%
fat/weight
and
western
containing
1%
cholesterol
or
15%
sugar.
MEDLINE
Embase
databases
were
searched
from
1946
August
2022,
32
preclinical
review.
HFD-induced
obesity
metabolic
disturbances
such
insulin
resistance
glucose
intolerance
replicated
most
studies,
but
with
methodological
variability.
Most
found
an
aggravating
effect
brain
Aβ
pathology,
whereas
tau
pathology
has
much
less
studied,
results
are
more
equivocal.
While
show
impairment
cognitive
behavior,
confounding
factors
may
blur
their
interpretation.
In
summary,
despite
conflicting
results,
exposing
rodents
highly
enriched
fat
induces
not
only
defects,
also
often
accompanied
by
aggravated
neuropathological
markers,
notably
burden.
Although
there
important
variations
between
methods,
particularly
lack
diet
characterization,
collectively
suggest
that
excessive
should
be
avoided
order
lower
incidence
Cells,
Journal Year:
2020,
Volume and Issue:
9(7), P. 1614 - 1614
Published: July 4, 2020
Aging
is
characterized
by
a
chronic
low-grade
sterile
inflammation
dubbed
as
inflammaging,
which
in
part
originates
from
accumulating
cellular
debris.
These,
acting
danger
signals
with
many
intrinsic
factors
such
cytokines,
are
sensed
network
of
pattern
recognition
receptors
and
other
cognate
receptors,
leading
to
the
activation
inflammasomes.
Due
inflammasome
activity-dependent
increase
levels
pro-inflammatory
interleukins
(IL-1β,
IL-18),
initiated,
resulting
tissue
injury
various
organs,
brain
spinal
cord
included.
Similarly,
age-related
diseases
central
nervous
system
(CNS),
prominent
moment,
cells
neurovascular
unit
occupy
significant
position.
In
this
review,
we
discuss
inflammatory
changes
normal
aging
summarize
current
knowledge
on
role
inflammasomes
contributing
mechanisms
common
CNS
diseases,
namely
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis
stroke,
all
occur
more
frequently
aging.
Frontiers in Physiology,
Journal Year:
2019,
Volume and Issue:
10
Published: Dec. 18, 2019
Growing
elderly
populations
are
an
increasingly
serious
health
and
socio-economic
concern
for
modern
societies.
Science
has
made
tremendous
progress
in
the
understanding
of
aging
itself
which
somehow
helped
medicine
to
extend
life
expectancies.
With
increase
expectancy,
incidence
chronic
age-related
diseases
(ARDs)
also
increased.
A
new
approach
trying
solve
this
problem
is
concept
geroscience.
This
implies
that
process
common
cause
all
ARDs.
The
corollary
consequence
such
thinking
we
can
should
treat
itself.
How
move
into
medical
practice
a
big
challenge,
but
if
consider
as
disease
solved.
However,
there
no
definition
what
is,
its
causes
are,
why
it
occurs,
target(s)
interventions
be,
impossible
definitively
conclude
disease.
On
contrary,
may
be
strongly
considered
not
treated;
nonetheless,
likely
amenable
optimization
changes/adaptations
at
individual
level
achieve
better
functional
healthspan.
